Mechanisms of antibiotic resistance in enterococci

Miller, William R; Munita, Jose M; Arias, Cesar A

doi:10.1586/14787210.2014.956092

Cited by 772Antibiotic Resistance in BacteriaAntimicrobial Resistance in StaphylococcusBacterial Genetics and Biotechnology

Mechanisms of antibiotic resistance in enterococci

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Miller, William R, Munita, Jose M, Arias, Cesar A·2014·Expert Review of Anti-infective Therapy

DOI 10.1586/14787210.2014.956092PMC PMC4433168

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Abstract

Multidrug-resistant (MDR) enterococci are important nosocomial pathogens and a growing clinical challenge. These organisms have developed resistance to virtually all antimicrobials currently used in clinical practice using a diverse number of genetic strategies. Due to this ability to recruit antibiotic resistance determinants, MDR enterococci display a wide repertoire of antibiotic resistance mechanisms including modification of drug targets, inactivation of therapeutic agents, overexpression of efflux pumps and a sophisticated cell envelope adaptive response that promotes survival in the human host and the nosocomial environment. MDR enterococci are well adapted to survive in the gastrointestinal tract and can become the dominant flora under antibiotic pressure, predisposing the severely ill and immunocompromised patient to invasive infections. A thorough understanding of the mechanisms underlying antibiotic resistance in enterococci is the first step for devising strategies to control the spread of these organisms and potentially establish novel therapeutic approaches.

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Changing D-Ala for D-Ser does not remove any of the five hydrogen bonds between vancomycin and its target, but the serine hydroxyl group reduces affinity less markedly than the D-Lac replacement.
“Although the change of D-Ala for D-Ser does not remove any of the 5 hydrogen bonds between vancomycin and its target, the presence of the hydroxyl group of serine affects the interaction of the antibiotic with the precursors reducing its affinity, albeit less markedly than with the D-Lac replacement (74).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [74]

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Mechanisms of Antibiotic Resistance
Munita, J. M., & Arias, C. A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.vmbf-0016-2015 · Cited by 2,782 · see citing works
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Surveillance of Enterococcus spp. reveals distinct species and antimicrobial resistance diversity across a One-Health continuum
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Antibiotic resistance propagation through probiotics
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Authors: Miller, W. R., Munita, J. M., & Arias, C. A.
Affiliations: Universidad del Desarrollo (CL)
ORCID: Miller, William R
Munita, Jose M
Venue: Expert Review of Anti-infective Therapy
Publisher: Informa UK Limited
Published: 2014-09-09
Volume: 12
Issue: 10
Pages: 1221-1236
ISSN: 1478-7210 (ISSN-L)
1744-8336
DOI: 10.1586/14787210.2014.956092
PMC: PMC4433168
OpenAlex: W2167956674
Cited by: 772
References: 136
Citations by year: 2026: 56 · 2025: 98 · 2024: 88 · 2023: 89 · 2022: 108 · 2021: 94 · 2020: 86 · 2019: 61 · 2018: 49 · 2017: 21 · 2016: 17 · 2015: 5
FWCI: 0.96
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Expert Review of Anti-infective Therapy (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01AI093749)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: antibiotic resistance, Enterococcus, multidrug resistance, drug target modification, antibiotic inactivation, efflux pumps, nosocomial pathogens, intestinal colonization, invasive infections, antimicrobial resistance determinants
MeSH terms: Anti-Bacterial Agents, Humans, Models, Biological, Gram-Positive Bacterial Infections, Enterococcus, Drug Resistance, Multiple, Bacterial

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Mechanisms of antibiotic resistance in enterococci

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