Breakthrough Fungal Infections in Patients With Leukemia Receiving Isavuconazole
Open accessAbstract
We retrospectively assessed breakthrough invasive fungal infections (b-IFIs) in 100 consecutive patients with leukemia receiving single-agent isavuconazole; 13 had documented b-IFIs (candidiasis in 6, mucormycosis in 4). All b-IFIs were observed in patients with prolonged neutropenia and active leukemia.
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The majority of breakthrough Candida infections occur in patients receiving antifungal prophylaxis with a triazole antifungal such as fluconazole, voriconazole, posaconazole, or isavuconazole.
“The majority of BT Candida infections occur in patients receiving antifungal prophylaxis with a triazole antifungal such as fluconazole, voriconazole, posaconazole or isavuconazole,94–96”
From Epidemiology of Invasive Candidiasis (2024) · cites this paper as [95]
The Discussion reports that Candida caused 54% of proven or probable breakthrough fungal infections in this leukemia cohort receiving isavuconazole. That is not the same as saying most breakthrough Candida infections occur in patients on triazole prophylaxis: the Results (p. 1611) say some patients with breakthrough infections received isavuconazole as treatment, and the paper does not establish the claimed majority across the four listed drugs. (LLM, conf=0.88)
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- Authors
- Rausch, C. R., DiPippo, A. J., Bose, P., & Kontoyiannis, D. P.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Kontoyiannis, Dimitrios P
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-05-16
- Volume
- 67
- Issue
- 10
- Pages
- 1610-1613
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- PMC
- PMC6454429
- OpenAlex
- W2803645787
- Semantic Scholar
- 11c990086a45ef3f98603a947e94b31a27af81e7
- Cited by
- 107
- References
- 13
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 5 · 2023: 16 · 2022: 7 · 2021: 19 · 2020: 27 · 2019: 15 · 2018: 6
- FWCI
- 12.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (P30CA016672)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- isavuconazole, leukemia, candidiasis, mucormycosis, neutropenia, antifungal prophylaxis, invasive fungal infections
- MeSH terms
- Invasive Fungal Infections, Adult, Aged, Aged, 80 and over, Antifungal Agents, Female, Humans, Leukemia, Male, Middle Aged, Nitriles, Pyridines, Retrospective Studies, Triazoles, Young Adult, Electronic Health Records, Candidemia
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