The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A Systematic and Critical Review of Bacteriophage Therapy Against Multidrug-resistant ESKAPE Organisms in Humans
Abstract
Bacteriophages (phages) may constitute a natural, safe, and effective strategy to prevent and control multidrug-resistant organisms (MDROs), and ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens in particular. Few clinical studies have assessed the safety and efficacy of phages in patients infected with MDROs. This systematic review summarizes and critically evaluates published studies of phages in clinical practice and presents the appropriate phage selection criteria, as well as recommendations for clinicians and scientists for a successful therapy. Articles were identified through a search of the PubMed, Ovid, EMBASE, and Cochrane Library databases. Among 1102 articles and abstracts, 30 studies were selected and evaluated using selective inclusion criteria, phage criteria, and study characteristics. Most studies showed efficacy (87%) and safety (67%) of the tested phages, but few studies examined phage resistance (35%). Clinical studies and regulatory changes are needed to determine the safety and efficacy of phages and to advance their use in patients with MDRO infections.
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Cites
Tacconelli, E., Carrara, E., Savoldi, A., Harbarth, S., Mendelson, M., Monnet, D. L., Pulcini, C., Kahlmeter, G., Kluytmans, J., Carmeli, Y., et al. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30753-3 · Cited by 6,142
Overview of Nosocomial Infections Caused by Gram-Negative Bacilli
Weinstein, R. A., Gaynes, R., Edwards, J. R., & System, N. N. I. S. (2005) · Clinical Infectious Diseases · doi:10.1086/432803 · Cited by 1,404
Cosgrove, S. E. (2006) · Clinical Infectious Diseases · doi:10.1086/499406 · Cited by 1,271
Cited by
Phage Therapy in the Resistance Era: Where Do We Stand and Where Are We Going?
Luong, T., Salabarria, A.-C., & Roach, D. R. (2020) · Clinical Therapeutics · doi:10.1016/j.clinthera.2020.07.014 · Cited by 266
Nir-Paz, R., Gelman, D., Khouri, A., Sisson, B. M., Fackler, J., Alkalay-Oren, S., Khalifa, L., Rimon, A., Yerushalmy, O., Bader, R., et al. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciz222 · Cited by 265
Metadata
- Authors
- El Haddad, L., Harb, C. P., Gebara, M. A., Stibich, M. A., & Chemaly, R. F.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-11-03
- Volume
- 69
- Issue
- 1
- Pages
- 167-178
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2898654474
- Cited by
- 185
- References
- 3
- FWCI
- 9.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- El Haddad, L., Harb, C. P., Gebara, M. A., Stibich, M. A., & Chemaly, R. F. (2019). A Systematic and Critical Review of Bacteriophage Therapy Against Multidrug-resistant ESKAPE Organisms in Humans. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciy947
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