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Cited by 52Dialysis and Renal Disease ManagementPhysical Activity and HealthCardiovascular and exercise physiology

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Twelve weeks of supervised exercise improves self-reported symptom burden and fatigue in chronic kidney disease: a secondary analysis of the ‘ExTra CKD’ trial

Open access
Wilkinson, Thomas J, Watson, Emma L, Gould, Douglas W, Xenophontos, Soteris, Clarke, Amy L, Vogt, Barbara P, Viana, João L, Smith, Alice C·2019·Clinical Kidney Journal
DOI 10.1093/ckj/sfy071PMC PMC6366144
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Abstract

BACKGROUND: Chronic kidney disease (CKD) patients experience a high symptom burden including fatigue, sleep difficulties, muscle weakness and pain. These symptoms reduce levels of physical function (PF) and activity, and contribute to poor health-related quality of life (HRQoL). Despite the gathering evidence of positive physiological changes following exercise in CKD, there is limited evidence on its effect on self-reported symptom burden, fatigue, HRQoL and physical activity. METHODS: ] not requiring renal replacement therapy underwent 12 weeks (3 times/week) of supervised aerobic exercise (AE), or a combination (CE) of AE plus resistance training. Outcomes included self-reported symptom burden, fatigue, HRQoL and physical activity. RESULTS: Exercise reduced the total number of symptoms reported by 17% and had favourable effects on fatigue in both groups. AE reduced the frequency of 'itching', 'impotence' and 'shortness of breath' symptoms, and the intrusiveness for symptoms of 'sleep disturbance', 'loss of muscular strength/power', 'muscle spasm/stiffness' and 'restless legs'. The addition of resistance exercise in the CE group saw a reduction in 'loss of muscular strength/power'. No changes were seen in subjective PF or physical activity levels. AE increased self-efficacy for physical activity. CONCLUSIONS: Supervised exercise had favourable effects on symptom frequency and intrusiveness, including substantial improvements in fatigue. Although the intervention did not improve self-reported physical activity levels, AE increased patients' self-efficacy for physical activity. These favourable changes in self-reported outcomes support the important role of exercise in CKD.

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Registry

Crossref · 10.1093/ckj/sfy071

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Figures

FIGURE 1 Individual changes in the number of symptoms reported pre- and post-exercise from the LUSS. Data show the reduction (or increase) in the number of symptoms for each of the 18 individual patients in each group.
FIGURE 1 Individual changes in the number of symptoms reported pre- and post-exercise from the LUSS. Data show the reduction (or increase) in the number of symptoms for each of the 18 individual patients in each group.CC BY-NC · PubMed Central

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Cited by

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Metadata

Authors
Wilkinson, T. J., Watson, E. L., Gould, D. W., Xenophontos, S., Clarke, A. L., Vogt, B. P., Viana, J. L., & Smith, A. C.
Affiliations
  • University of Leicester (GB)
  • Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
  • Department of Clinical Medicine, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP, São Paulo, Brazil
  • Loughborough University (GB)
Corresponding author
Wilkinson, Thomas J
ORCID
Venue
Clinical Kidney Journal
Publisher
Oxford University Press (OUP)
Published
2018-08-13
Volume
12
Issue
1
Pages
113-121
ISSN
  • 2048-8505 (ISSN-L)
  • 2048-8513
DOI
10.1093/ckj/sfy071
PMC
PMC6366144
OpenAlex
W2887885660
Cited by
52
References
53
Citations by year
2026: 1 · 2025: 7 · 2024: 5 · 2023: 7 · 2022: 12 · 2021: 11 · 2020: 4 · 2019: 3 · 2018: 2
FWCI
4.10
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Kidney Journal (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Warwick Research Archive Portal (University of Warwick) (acceptedVersion)
  • Americanae (AECID Library) (submittedVersion, other-oa)
  • Figshare (submittedVersion, cc-by-nc)
  • Leicester Research Archive (University of Leicester) (submittedVersion, cc-by-nc)
  • Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Funders
  • Stoneygate Trust
  • National Institute for Health Research
  • Leicester Biomedical Research Centre
  • NHS
  • NIHR
  • BRC
  • Kidney Research UK Post-Doctoral Fellowship
  • Improvement of Higher Education Personnel
  • Ministry of Education
Topics
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
chronic kidney disease, supervised exercise, aerobic exercise, resistance training, fatigue, symptom burden, health-related quality of life, physical activity, self-efficacy, sleep disorders, muscle weakness

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