The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Association between Physical Performance and All-Cause Mortality in CKD
Open accessAbstract
In older adults, measurements of physical performance assess physical function and associate with mortality and disability. Muscle wasting and diminished physical performance often accompany CKD, resembling physiologic aging, but whether physical performance associates with clinical outcome in CKD is unknown. We evaluated 385 ambulatory, stroke-free participants with stage 2-4 CKD enrolled in clinic-based cohorts at the University of Washington and University of Maryland and Veterans Affairs Maryland Healthcare systems. We compared handgrip strength, usual gait speed, timed up and go (TUAG), and 6-minute walking distance with normative values and constructed Cox proportional hazards models and receiver operating characteristic curves to test associations with all-cause mortality. Mean age was 61 years and the mean estimated GFR was 41 ml/min per 1.73 m(2). Measures of lower extremity performance were at least 30% lower than predicted, but handgrip strength was relatively preserved. Fifty deaths occurred during the median 3-year follow-up period. After adjustment, each 0.1-m/s decrement in gait speed associated with a 26% higher risk for death, and each 1-second longer TUAG associated with an 8% higher risk for death. On the basis of the receiver operating characteristic analysis, gait speed and TUAG more strongly predicted 3-year mortality than kidney function or commonly measured serum biomarkers. Adding gait speed to a model that included estimated GFR significantly improved the prediction of 3-year mortality. In summary, impaired physical performance of the lower extremities is common in CKD and strongly associates with all-cause mortality.
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Cites
A New Equation to Estimate Glomerular Filtration Rate
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Cited by
KDIGO 2020 Clinical practice guideline for diabetes management in chronic kidney disease
de Boer, I. H., Caramori, M. L., Chan, J. C. N., Heerspink, H. J. L., Hurst, C., Khunti, K., Liew, A., Michos, E. D., Navaneethan, S. D., Olowu, W. A., et al. (2020) · Kidney International · doi:10.1016/j.kint.2020.06.019 · Cited by 1,399
Self-citationKDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease
Rossing, P., Caramori, M. L., Chan, J. C. N., Heerspink, H. J. L., Hurst, C., Khunti, K., Liew, A., Michos, E. D., Navaneethan, S. D., Olowu, W. A., et al. (2022) · Kidney International · doi:10.1016/j.kint.2022.06.008 · Cited by 1,373
Self-citationVeronese, N., Stubbs, B., Volpato, S., Zuliani, G., Maggi, S., Cesari, M., Lipnicki, D. M., Smith, L., Schofield, P., Firth, J., et al. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.06.007 · Cited by 209
Exercise Training in CKD: Efficacy, Adherence, and Safety
Howden, E. J., Coombes, J. S., Strand, H., Douglas, B., Campbell, K. L., & Isbel, N. M. (2015) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2014.09.017 · Cited by 143
Zhang, L., Wang, Y., Xiong, L., Luo, Y., Huang, Z., & Yi, B. (2019) · BMC Nephrology · doi:10.1186/s12882-019-1586-5 · Cited by 132
Metadata
- Authors
- Roshanravan, B., Robinson-Cohen, C., Patel, K. V., Ayers, E., Littman, A. J., de Boer, I. H., Ikizler, T. A., Himmelfarb, J., Katzel, L. I., Kestenbaum, B., & Seliger, S.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2013-05
- Volume
- 24
- Issue
- 5
- Pages
- 822-830
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2164972088
- Cited by
- 459
- References
- 7
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Roshanravan, B., Robinson-Cohen, C., Patel, K. V., Ayers, E., Littman, A. J., de Boer, I. H., Ikizler, T. A., Himmelfarb, J., Katzel, L. I., Kestenbaum, B., & Seliger, S. (2013). Association between Physical Performance and All-Cause Mortality in CKD. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.2012070702
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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