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Automated Reaction-Rate Method for Determination of Serum Creatinine with the CentrifiChem
Abstract
An automated kinetic method to determine creatinine in serum with the Jaffé reaction is described. The method does not require deproteinization or adsorption of creatinine on Fuller's earth or ion-exchange resin. A maximum of 29 serum samples, standards, and control sera can be assayed in less than 1.5 min. Interferences by most of the known Jaffé-positive serum constituents were studied and minimized by optimal selection of the time interval during which the reaction rate was measured. Results of precision studies and correlation with a manual method requiring adsorption of creatinine on ion-exchange resin are reported. Spectroscopic data suggest that the product of reaction between picrate and creatinine is a 1:1 adduct of the two starting molecules.
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Cited by
Analytical Reviews in Clinical Biochemistry: The Estimation of Creatinine
Spencer, K. (1986) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1177/000456328602300101 · Cited by 375
Molitch, M. E., Steffes, M., Sun, W., Rutledge, B., Cleary, P., de Boer, I. H., Zinman, B., Lachin, J., & for the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Group (2010) · Diabetes Care · doi:10.2337/dc09-1098 · Cited by 306
Acute Phase Response in Dairy Cows with Experimentally Induced Escherichia coli Mastitis
Hirvonen, J., Eklund, K., Teppo, A. M., Huszenicza, G., Kulcsar, M., Saloniemi, H., & Pyörälä, S. (1999) · Acta Veterinaria Scandinavica · doi:10.1186/bf03547039 · Cited by 137
Ozturk, O., Eroglu, H. A., Ustebay, S., Kuzucu, M., & Adali, Y. (2018) · Acta Cirurgica Brasileira · doi:10.1590/s0102-865020180060000005 · Cited by 17
Metadata
- Authors
- Fabiny, D. L., & Ertingshausen, G.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1971-08-01
- Volume
- 17
- Issue
- 8
- Pages
- 696-700
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W1863746179
- Cited by
- 543
- References
- 0
- FWCI
- 7.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Automated Reaction-Rate Method for Determination of Serum Creatinine with the CentrifiChem. https://app.cochat.ai/papers/10.1093/clinchem/17.8.696
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- Fabiny, D. L., & Ertingshausen, G. (1971). Automated Reaction-Rate Method for Determination of Serum Creatinine with the CentrifiChem. Clinical Chemistry. https://doi.org/10.1093/clinchem/17.8.696
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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