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Cited by 128Thyroid Disorders and TreatmentsClinical Laboratory Practices and Quality ControlThyroid Cancer Diagnosis and Treatment

Direct determination of free thyroxin in undiluted serum by equilibrium dialysis/radioimmunoassay.

Nelson, J C, Tomei, R T·1988·Clinical Chemistry
DOI 10.1093/clinchem/34.9.1733
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Abstract

We have designed a re-usable dialysis cell and a complex dialysis buffer, with which undiluted serum samples can be dialyzed with minimal changes in their serum matrix. Dialysate thyroxin (free T4) is then measured by a sensitive RIA for T4. The range of reportability was 2-128 ng/L, the normal range was 8-27 ng/L, and the interassay CV was 7%. Free T4 concentrations in various disorders were as follows: hyperthyroidism, 32-478 ng/L; in both excess thyroxin-binding globulin (TBG) and familial dysalbuminemic hyperthyroxinemia, 9-27 ng/L; primary hypothyroidism, less than 2-7 ng/L; central hypothyroidism, 4-6 ng/L; severe TBG deficiency, 9-25 ng/L; hypothyroxinemias of nonthyroidal illness, 8-35 ng/L. With this free-T4 assay, which is adaptable to clinical laboratory use, one can differentiate hyperthyroidism from the major euthyroid hyperthyroxinemias and hypothyroidism from the major euthyroid hypothyroxinemias.

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Crossref · 10.1093/clinchem/34.9.1733

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Authors
Nelson, J. C., & Tomei, R. T.
Affiliations
White Memorial Medical Center (US)
Venue
Clinical Chemistry
Publisher
Oxford University Press (OUP)
Published
1988-09-01
Volume
34
Issue
9
Pages
1737-1744
ISSN
  • 0009-9147 (ISSN-L)
  • 1530-8561
DOI
10.1093/clinchem/34.9.1733
OpenAlex
W2149547682
Cited by
128
References
40
Citations by year
2026: 1 · 2025: 1 · 2023: 3 · 2022: 1 · 2020: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 4
FWCI
0.89
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • Clinical Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords
free thyroxine, equilibrium dialysis, thyroxine-binding globulin, familial dysalbuminemic hyperthyroxinemia, hyperthyroidism, hypothyroidism, central hypothyroidism, low T3 syndrome, thyroid function tests
MeSH terms
Adult, Dialysis, Humans, Hyperthyroidism, Hyperthyroxinemia, Hypothyroidism, Radioimmunoassay, Reference Values, Serum Albumin, Thyroid Diseases, Thyroxine, Thyroxine-Binding Proteins

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