The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Relationship of serum estradiol and progesterone concentrations to the excretion profiles of their major urinary metabolites as measured by enzyme immunoassay and radioimmunoassay
Abstract
Paired daily blood and urine samples were collected from 10 apparently healthy premenopausal women to compare the hormone profiles of estradiol (E2) and progesterone in serum with those of estrone conjugates (E1Conj) and pregnanediol-3-glucuronide (PdG) in urine. Serum hormones were measured by radioimmunoassay (RIA) kits, whereas the urinary steroid metabolites were assessed by both RIA and enzyme immunoassay (EIA). RIA and EIA values for urinary E1Conj and PdG were not different, and both methods produced urinary profiles that paralleled the profile of the parent steroid in serum. However, the simplicity, flexibility, and economy of EIA will make this method more widely applicable. Mean E1Conj values lagged behind concentrations of serum E2 by one day or less, whereas daily urinary PdG profiles lagged behind serum progesterone by one to two days. Mean urinary profiles of E1Conj were similar whether or not creatinine was used to adjust for urine volume; however, creatinine indexing was beneficial when urinary profiles in individual cycles were compared with changes of serum E2.
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Cites
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Self-citationNon-radiometric methods for immunoassay of steroid hormones.
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Self-citationA simple and efficient method for raising steroid antibodies in rabbits
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Cited by
Miller, R. C., Brindle, E., Holman, D. J., Shofer, J., Klein, N. A., Soules, M. R., & O’Connor, K. A. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2004.032292 · Cited by 317
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Self-citationIncidence of migraine relative to menstrual cycle phases of rising and falling estrogen
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De Souza, M. J., Toombs, R. J., Scheid, J. L., O'Donnell, E., West, S. L., & Williams, N. I. (2010) · Human Reproduction · doi:10.1093/humrep/dep411 · Cited by 305
Treatment of endometriosis with the antiprogesterone mifepristone (RU486)
Michael Kettel, L., Murphy, A. A., Morales, A. J., Ulmann, A., Baulieu, E. E., & Yen, S. S. C. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58022-4 · Cited by 216
Metadata
- Authors
- Munro, C. J., Stabenfeldt, G. H., Cragun, J. R., Addiego, L. A., Overstreet, J. W., & Lasley, B. L.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1991-06-01
- Volume
- 37
- Issue
- 6
- Pages
- 838-844
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2104090353
- Cited by
- 422
- References
- 11
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Relationship of serum estradiol and progesterone concentrations to the excretion profiles of their major urinary metabolites as measured by enzyme immunoassay and radioimmunoassay. https://app.cochat.ai/papers/10.1093/clinchem/37.6.838
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- Munro, C. J., Stabenfeldt, G. H., Cragun, J. R., Addiego, L. A., Overstreet, J. W., & Lasley, B. L. (1991). Relationship of serum estradiol and progesterone concentrations to the excretion profiles of their major urinary metabolites as measured by enzyme immunoassay and radioimmunoassay. Clinical Chemistry. https://doi.org/10.1093/clinchem/37.6.838
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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