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Rapid, fully automated measurement of plasma homocyst(e)ine with the Abbott IMx analyzer
Abstract
We have developed a totally automated fluorescence polarization immunoassay for homocyst(e)ine with no pretreatment or chromatographic steps. Comparison with four well-established chromatographic methods yielded r values ranging from 0.980 to 0.997 and slopes from 1.030 to 1.493. Inter- and intraassay CVs ranged from 0.0% to 8.0% and from 0.0% to 6.4%, respectively. Imprecision (CV) of measuring six plasma samples on three instruments ranged from 6.3% to 10.2%. The assay was linear for plasma samples diluted with buffer from 0 to 8-fold. Mean recovery of homocysteine added to two plasma samples was 97.1% and 99.9%. The assay exhibited almost no cross-reactivity towards cysteine and methionine, and a batch of 20 samples can be processed in 60 min.
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Citations
Cited by
Homocysteine and Cardiovascular Disease
Refsum, H., Ueland, P. M., Nygård, O., & Vollset, S. E. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.31 · Cited by 2,180
Facts and recommendations about total homocysteine determinations: an expert opinion
Refsum, H., Smith, A. D., Ueland, P. M., Nexo, E., Clarke, R., McPartlin, J., Johnston, C., Engbaek, F., Schneede, J., McPartlin, C., et al. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2003.021634 · Cited by 1,056
Morris, M. S., Jacques, P. F., Rosenberg, I. H., & Selhub, J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.1.193 · Cited by 608
Vitamin B12 and folate deficiency in later life
Clarke, R., Grimley Evans, J., Schneede, J., Nexo, E., Bates, C., Fletcher, A., Prentice, A., Johnston, C., Ueland, P. M., Refsum, H., et al. (2004) · Age and Ageing · doi:10.1093/ageing/afg109 · Cited by 357
Elias, M. F., Robbins, M. A., Budge, M. M., Elias, P. K., Brennan, S. L., Johnston, C., Nagy, Z., & Bates, C. J. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000221380.92521.51 · Cited by 94
Metadata
- Authors
- Shipchandler, M. T., & Moore, E. G.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-07-01
- Volume
- 41
- Issue
- 7
- Pages
- 991-994
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W1937693126
- Cited by
- 379
- References
- 0
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Rapid, fully automated measurement of plasma homocyst(e)ine with the Abbott IMx analyzer. https://app.cochat.ai/papers/10.1093/clinchem/41.7.991
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- Shipchandler, M. T., & Moore, E. G. (1995). Rapid, fully automated measurement of plasma homocyst(e)ine with the Abbott IMx analyzer. Clinical Chemistry. https://doi.org/10.1093/clinchem/41.7.991
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
