Facts and recommendations about total homocysteine determinations: an expert opinion

The Metabolic and Molecular Bases of Inherited Disease

Scriver, R. C. (1995) · Medical Entomology and Zoology · Cited by 12,101 · see citing works

Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study

(1991) · The Lancet · doi:10.1016/0140-6736(91)90133-a · Cited by 3,472 · see citing works

Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease

Seshadri, S., Beiser, A., Selhub, J., Jacques, P. F., Rosenberg, I. H., D'Agostino, R. B., Wilson, P. W. F., & Wolf, P. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011613 · Cited by 3,237 · see citing works

Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation

Czeizel, A. E., & Dudás, I. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212243272602 · Cited by 3,200 · see citing works

Prevention of neural tube defects: Results of the Medical Research Council vitamin study

Wald, N., Sneddon, J., Densem, J. W., Frost, C. D., & Stone, R. (1992) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(92)90076-u · Cited by 2,364 · see citing works

Homocysteine and Cardiovascular Disease

Refsum, H., Ueland, P. M., Nygård, O., & Vollset, S. E. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.31 · Cited by 2,180 · see citing works

Homocysteine and Risk of Ischemic Heart Disease and Stroke: A Meta-analysis

Homocysteine Studies Collaboration (2002) · JAMA · doi:10.1001/jama.288.16.2015 · Cited by 2,059 · see citing works

Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population

Selhub, J. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1993.03510220049033 · Cited by 1,972 · see citing works

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis

Wald, D. S., Law, M., & Morris, J. K. (2002) · BMJ · doi:10.1136/bmj.325.7374.1202 · Cited by 1,945 · see citing works

Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.

Ks, M. (1969) · PubMed · Cited by 1,824 · see citing works

Plasma Homocysteine Levels and Mortality in Patients with Coronary Artery Disease

Nygard, O. K., Nordrehaug, J. E., Refsum, H., Ueland, P. M., Farstad, M., & Vollset, S. E. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707243370403 · Cited by 1,746 · see citing works

Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project.

Graham, I. M., Daly, L. E., Refsum, H. M., Robinson, K., Brattström, L. E., Ueland, P. M., Palma-Reis, R. J., Boers, G. H., Sheahan, R. G., Israelsson, B., et al. (1997) · PubMed · doi:10.1001/jama.1997.03540460039030 · Cited by 1,738 · see citing works

Folate, Vitamin B12, and Serum Total Homocysteine Levels in Confirmed Alzheimer Disease

Clarke, R., Smith, A. D., Jobst, K. A., Refsum, H., Sutton, L., & Ueland, P. M. (1998) · Archives of Neurology · doi:10.1001/archneur.55.11.1449 · Cited by 1,408 · see citing works

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

Jacques, P. F., Bostom, A. G., Williams, R. R., Ellison, R. C., Eckfeldt, J. H., Rosenberg, I. H., Selhub, J., & Rozen, R. R. (1996) · Circulation · doi:10.1161/01.cir.93.1.7 · Cited by 1,380 · see citing works

Prevention of Neural-Tube Defects with Folic Acid in China

Berry, R. J., Li, Z., Erickson, J. D., Li, S., Moore, C. A., Wang, H., Mulinare, J., Zhao, P., Wong, L.-Y., Gindler, J., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199911113412001 · Cited by 1,353 · see citing works

Novel Risk Factors for Systemic Atherosclerosis

Ridker, P. M., Stampfer, M. J., & Rifai, N. (2001) · JAMA · doi:10.1001/jama.285.19.2481 · Cited by 1,300 · see citing works

Neuropsychiatric Disorders Caused by Cobalamin Deficiency in the Absence of Anemia or Macrocytosis

Lindenbaum, J., Healton, E. B., Savage, D. G., Brust, J. C. M., Garrett, T. J., Podell, E. R., Margell, P. D., Stabler, S. P., & Allen, R. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806303182604 · Cited by 1,300 · see citing works

Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials

Homocysteine Lowering Trialists' Collaboration (1998) · BMJ · doi:10.1136/bmj.316.7135.894 · Cited by 1,085 · see citing works

Prevention of Neural-Tube Defects with Folic Acid in China

(1999) · New England Journal of Medicine · doi:10.1056/nejm199912093412424 · Cited by 1,075 · see citing works

Homocysteine and vascular disease

Hankey, G. J., & Eikelboom, J. W. (1999) · The Lancet · doi:10.1016/s0140-6736(98)11058-9 · Cited by 1,070 · see citing works

Impact of Folic Acid Fortification of the US Food Supply on the Occurrence of Neural Tube Defects

Honein, M. A. (2001) · JAMA · doi:10.1001/jama.285.23.2981 · Cited by 1,050 · see citing works

Total Plasma Homocysteine and Cardiovascular Risk Profile

Nygard, O. K., Vollset, S. E., Refsum, H., Stensvold, I., Tverdal, A., Nordrehaug, J. E., Ueland, P. M., & Kvåle, G. (1995) · JAMA · doi:10.1001/jama.1995.03530190040032 · Cited by 1,043 · see citing works

Disorders of transsulfuration

Mudd, S. H. (1989) · Medical Entomology and Zoology · Cited by 1,023 · see citing works

Total homocysteine in plasma or serum: methods and clinical applications

Ueland, P. M., Refsum, H., Stabler, S. P., Malinow, M. R., Andersson, A. D. R., & Allen, R. H. (1993) · Clinical Chemistry · doi:10.1093/clinchem/39.9.1764 · Cited by 984 · see citing works

MTHFR 677C→T Polymorphism and Risk of Coronary Heart Disease

Klerk, M., Verhoef, P., Clarke, R., Blom, H. J., Kok, F. J., & Schouten, E. G. (2002) · JAMA · doi:10.1001/jama.288.16.2023 · Cited by 932 · see citing works

Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men

Perry, I. J., Morris, R. W., Ebrahim, S. B. J., Shaper, A. G., Refsum, H., & Ueland, P. M. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92407-8 · Cited by 880 · see citing works

Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies

Savage, D. G., Lindenbaum, J., Stabler, S. P., & Allen, R. H. (1994) · The American Journal of Medicine · doi:10.1016/0002-9343(94)90149-x · Cited by 707 · see citing works

Prevalence of cobalamin deficiency in the Framingham elderly population

Lindenbaum, J., Rosenberg, I. H., Wilson, P., Stabler, S., & Allen, R. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.1.2 · Cited by 672 · see citing works

Common Methylenetetrahydrofolate Reductase Gene Mutation Leads to Hyperhomocysteinemia but Not to Vascular Disease

Brattström, L. E., Wilcken, D. E. L., Öhrvik, J., & Brudin, L. H. (1998) · Circulation · doi:10.1161/01.cir.98.23.2520 · Cited by 658 · see citing works

Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.

Kluijtmans, L. A. J., van den Heuvel, L. P., Boers, G. H. J., Frosst, P. D., Stevens, E. M., van Oost, B. A., den Heijer, M., Trijbels, F. J. M., Rozen, R. R., & Blom, H. J. (1996) · PubMed Central · Cited by 653 · see citing works

Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort

Jacques, P. F., Bostom, A. G., Wilson, P. W. F., Rich, S. E., Rosenberg, I. H., & Selhub, J. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.3.613 · Cited by 628 · see citing works

Folic acid: influence on the outcome of pregnancy

Scholl, T. O., & Johnson, W. G. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.5.1295s · Cited by 617 · see citing works

Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition

Chen, Z. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.433 · Cited by 608 · see citing works

Homocyst(e)ine, Diet, and Cardiovascular Diseases: A Statement for Healthcare Professionals From the Nutrition Committee, American Heart Association

Malinow, M. R., Bostom, A. G., & Krauss, R. M. (1999) · Circulation · doi:10.1161/01.cir.99.1.178 · Cited by 586 · see citing works

Homocysteine, folate, methylation, and monoamine metabolism in depression

Bottiglieri, T. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.2.228 · Cited by 546 · see citing works

Biological and clinical implications of the MTHFR C677T polymorphism

Ueland, P. M., Hustad, S., Schneede, J., Refsum, H., & Vollset, S. E. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01675-8 · Cited by 527 · see citing works

Laboratory Diagnosis of Vitamin B12 and Folate Deficiency

Snow, C. F. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.12.1289 · Cited by 516 · see citing works

The controversy over homocysteine and cardiovascular risk

Ueland, P. M., Refsum, H. M., Beresford, S. A. A., & Vollset, S. E. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.2.324 · Cited by 514 · see citing works

Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study

Riggs, K., Spiro, A., Tucker, K. L., & Rush, D. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.3.306 · Cited by 504 · see citing works

Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry.

Stabler, S. P., Marcell, P. D., Podell, E. R., Allen, R. H., Savage, D., & Lindenbaum, J. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113343 · Cited by 477 · see citing works

Homocysteine and other thiols in plasma and urine: automated determination and sample stability

Fiskerstrand, T., Refsum, H., Kvalheim, G., & Ueland, P. M. (1993) · Clinical Chemistry · doi:10.1093/clinchem/39.2.263 · Cited by 469 · see citing works

Vitamin B 12 and folate in relation to the development of Alzheimer’s disease

Wang, H., Wåhlin, Å., Basun, H., Fastbom, J., Winblad, B. G., & Fratiglioni, L. (2001) · Neurology · doi:10.1212/wnl.56.9.1188 · Cited by 469 · see citing works

B vitamins, homocysteine, and neurocognitive function in the elderly

Selhub, J., Bagley, L. C., Miller, J. W., & Rosenberg, I. H. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.614s · Cited by 462 · see citing works

Effective Treatment of Cobalamin Deficiency With Oral Cobalamin

Kuzminski, A. M., Giacco, E. J. D., Allen, R. H., Stabler, S. P., & Lindenbaum, J. (1998) · Blood · doi:10.1182/blood.v92.4.1191 · Cited by 461 · see citing works

Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine Study

Vollset, S. E., Refsum, H., Irgens, L. M., Emblem, B. M., Tverdal, A., Gjessing, H. K., Monsen, A. L. B., & Ueland, P. M. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.4.962 · Cited by 456 · see citing works

Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome

James, S. J., Pogribna, M., Pogribny, I. P., Melnyk, S., Hine, R. J., Gibson, J. B., Yi, P., Tafoya, D. L., Swenson, D. H., Wilson, V. L., et al. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.4.495 · Cited by 445 · see citing works

Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study

Nygard, O. K., Refsum, H., Ueland, P. M., & Se, V. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.2.263 · Cited by 444 · see citing works

Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations

Lindenbaum, J., Savage, D. G., Stabler, S. P., & Allen, R. H. (1990) · American Journal of Hematology · doi:10.1002/ajh.2830340205 · Cited by 442 · see citing works

A Common Variant in Methionine Synthase Reductase Combined with Low Cobalamin (Vitamin B12) Increases Risk for Spina Bifida

Wilson, A., Platt, R. W., Wu, Q. H., Leclerc, D., Christensen, B., Yang, H., Gravel, R. A., & Rozen, R. R. (1999) · Molecular Genetics and Metabolism · doi:10.1006/mgme.1999.2879 · Cited by 439 · see citing works

Homocysteinemia due to folate deficiency

Kang, S., WONG, P. W. K., & Norušis, M. J. (1987) · Metabolism · doi:10.1016/0026-0495(87)90043-6 · Cited by 423 · see citing works

High Prevalence of Cobalamin Deficiency in Elderly Outpatients

Pennypacker, L. C., Allen, R. H., Kelly, J. P., Matthews, L. M., Grigsby, J., Kaye, K., Lindenbaum, J., & Stabler, S. P. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb03641.x · Cited by 422 · see citing works

Plasma homocysteine as a risk factor for atherothrombotic events in systemic lupus erythematosus

Petri, M., Roubenoff, R., Dallal, G. E., Nadeau, M., Selhub, J., & Rosenberg, I. H. (1996) · The Lancet · doi:10.1016/s0140-6736(96)03032-2 · Cited by 418 · see citing works

Vitamin B12 deficiency in the elderly.

Baik, H.-W., & Russell, R. M. (1999) · Annual review of nutrition · doi:10.1146/annurev.nutr.19.1.357 · Cited by 415 · see citing works

Maternal hyperhomocysteinemia: A risk factor for neural-tube defects?

Steegers‐Theunissen, R. P. M., Boers, G. H. J., Trijbels, F. J. M., Finkelstein, J. D., Blom, H. J., Thomas, C. M. G., Borm, G. F., Wouters, M. G. A. J., & Eskes, T. K. A. B. (1994) · Metabolism · doi:10.1016/0026-0495(94)90004-3 · Cited by 408 · see citing works

Vitamin B₁₂, Folate, and Homocysteine in Depression: The Rotterdam Study

Tiemeier, H., van Tuijl, H. R., Hofman, A., Meijer, J., Kiliaan, A. J., & Breteler, M. M. B. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.12.2099 · Cited by 408 · see citing works

Prospective Study of Hyperhomocysteinemia as an Adverse Cardiovascular Risk Factor in End-Stage Renal Disease

Moustapha, A., Naso, A., Nahlawi, M., et al. (1998) · Circulation · doi:10.1161/01.cir.97.2.138 · Cited by 407 · see citing works

Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: a systematic review

Ray, J. G., & Laskin, C. A. (1999) · Placenta · doi:10.1053/plac.1999.0417 · Cited by 401 · see citing works

Homocysteine in Health and Disease

(2003) · Journal of Interventional Cardiology · doi:10.1046/j.1540-8183.2003.80332.x · Cited by 400 · see citing works

Rapid, fully automated measurement of plasma homocyst(e)ine with the Abbott IMx analyzer

Shipchandler, M. T., & Moore, E. G. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.7.991 · Cited by 384 · see citing works

Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians

Refsum, H., Yajnik, C. S., Gadkari, M. A., Schneede, J., Vollset, S. E., Örning, L., Guttormsen, A. B., Joglekar, A., Sayyad, M. G., Ulvik, A., et al. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.2.233 · Cited by 383 · see citing works

Cobalamin and Folate Evaluation: Measurement of Methylmalonic Acid and Homocysteine vs Vitamin B12 and Folate

Klee, G. G. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.8.1277 · Cited by 382 · see citing works

Clinical spectrum and diagnosis of cobalamin deficiency [see comments]

Stabler, S. P., Allen, R. H., Savage, D. G., & Lindenbaum, J. (1990) · Blood · doi:10.1182/blood.v76.5.871.871 · Cited by 379 · see citing works

Homocysteine and Ischemic Heart Disease

Wald, N., Watt, H., Law, M. R., Weir, D. G., McPartlin, J. M., & Scott, J. M. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.8.862 · Cited by 375 · see citing works

Polymorphisms in Genes Involved in Folate Metabolism as Maternal Risk Factors for Down Syndrome

Hobbs, C. A., Sherman, S. L., Yi, P., Hopkins, S. E., Torfs, C. P., Hine, R. J., Pogribna, M., Rozen, R. R., & James, S. J. (2000) · The American Journal of Human Genetics · doi:10.1086/303055 · Cited by 361 · see citing works

Homocysteine, silent brain infarcts, and white matter lesions: The Rotterdam scan study

Vermeer, S. E., van Dijk, E. J., Koudstaal, P. J., Oudkerk, M., Albert Hofman, D., Clarke, R., & Breteler, M. M. B. (2002) · Annals of Neurology · doi:10.1002/ana.10111 · Cited by 353 · see citing works

Diagnosis of cobalamin deficiency I: Usefulness of serum methylmalonic acid and total homocysteine concentrations

Allen, R. H., Stabler, S. P., Savage, D. G., & Lindenbaum, J. (1990) · American Journal of Hematology · doi:10.1002/ajh.2830340204 · Cited by 344 · see citing works

The Hordaland Homocysteine Studies

Ueland, P. M., Nygard, O. K., Vollset, S. E., & Refsum, H. (2001) · Lipids · doi:10.1007/s11745-001-0679-7 · Cited by 327 · see citing works

Plasma total homocysteine and cysteine in relation to glomerular filtration rate in diabetes mellitus

Wollesen, F., Brattström, L. E., Refsum, H., Ueland, P. M., Berglund, L., & Berne, C. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.0550031028.x · Cited by 325 · see citing works

Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: a randomised, placebo-controlled trial

Vermeulen, E. G., Stehouwer, C. D. A., Twisk, J. W. R., van den Berg, M., de Jong, S., Mackaay, A. J. C., van Campen, C. M., Visser, F. C., Jakobs, C., Bulterijs, E., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(99)07391-2 · Cited by 323 · see citing works

Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status

Andersson, A. D. R., Brattström, L. E., Israelsson, B., ISAKSSON, A., Hamfelt, A., & Hultberg, B. L. (1992) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1992.tb01940.x · Cited by 317 · see citing works

Blood Levels of Homocysteine and Increased Risks of Cardiovascular Disease

Christen, W. G., Ajani, U. A., Glynn, R. J., & Hennekens, C. H. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.4.422 · Cited by 307 · see citing works

Radioenzymic determination of homocysteine in plasma and urine.

Refsum, H., Helland, S., & Ueland, P. M. (1985) · Clinical Chemistry · doi:10.1093/clinchem/31.4.624 · Cited by 307 · see citing works

The common 'thermolabile' variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia

Harmon, D. L., Woodside, J. V., YARNELL, J. W. G., McMaster, D., Young, I. S., McCrum, E. E., GEY, K. F., Whitehead, A. S., & Evans, A. E. (1996) · QJM · doi:10.1093/qjmed/89.8.571 · Cited by 305 · see citing works

Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis

Nelen, W. L. D. M., Blom, H. J., Steegers, E. A. P., den Heijer, M., & Eskes, T. K. A. B. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01595-8 · Cited by 304 · see citing works

Elevated Fasting Total Plasma Homocysteine Levels and Cardiovascular Disease Outcomes in Maintenance Dialysis Patients

Bostom, A. G., Shemin, D. G., Verhoef, P., Nadeau, M., Jacques, P. F., Selhub, J., Dworkin, L. D., & Rosenberg, I. H. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2554 · Cited by 294 · see citing works

Association of neural tube defects and folic acid food fortification in Canada

Ray, J. G., Meier, C., Vermeulen, M. J., Boss, S. C., WYATT, P. R., & Cole, D. E. C. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11994-5 · Cited by 294 · see citing works

Clinical spectrum and diagnosis of cobalamin deficiency [see comments]

Stabler, S., Allen, R., Savage, D., et al. (1990) · Blood · doi:10.1182/blood.v76.5.871.bloodjournal765871 · Cited by 294 · see citing works

Folate, Homocysteine and Neural Tube Defects: An Overview

van der Put, N. M. J., van Straaten, H. W. M., Trijbels, F. J. M., & Blom, H. J. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020122600402 · Cited by 292 · see citing works

Quantitation of total homocysteine, total cysteine, and methionine in normal serum and urine using capillary gas chromatography-mass spectrometry

Stabler, S. P., Marcell, P. D., Podell, E. R., & Allen, R. H. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90026-1 · Cited by 289 · see citing works

Folate, vitamin B12, and homocysteine in major depressive disorder

(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.3.426 · Cited by 287 · see citing works

Hyperhomocysteinemia predicts cardiovascular outcomes in hemodialysis patients

Mallamaci, F., Zoccali, C., Tripepi, G. L., et al. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00144.x · Cited by 285 · see citing works

Vitamin B12 Deficiency and Depression in Physically Disabled Older Women: Epidemiologic Evidence From the Women’s Health and Aging Study

Penninx, B. W. J. H., Guralnik, J. M., Ferrucci, L., Fried, L. P., Allen, R. H., & Stabler, S. P. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.715 · Cited by 285 · see citing works

Folate, vitamin B12 and Vitamin B6 and One Carbon Metabolism

Selhub, J. (2000) · Dialnet (Universidad de la Rioja) · Cited by 284 · see citing works

Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss

Wouters, M. G. A. J., Boers, G. H. J., Blom, H. J., Trijbels, F. J. M., Thomas, C. M. G., Borm, G. F., Steegers‐Theunissen, R. P. M., & Eskes, T. K. A. B. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56282-7 · Cited by 282 · see citing works

Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun Study

Snowdon, D. A., Tully, C. L., Smith, C. D., Riley, K. P., & Markesbery, W. R. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.4.993 · Cited by 274 · see citing works

Hyperhomocysteinemia Increases Risk of Death, Especially in Type 2 Diabetes

Hoogeveen, E. K., Kostense, P. J., Jakobs, C., et al. (2000) · Circulation · doi:10.1161/01.cir.101.13.1506 · Cited by 273 · see citing works

Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter). The Hordaland Homocysteine Study.

Guttormsen, A. B., Ueland, P. M., Nesthus, I., Nygard, O. K., Schneede, J., Vollset, S. E., & Refsum, H. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119024 · Cited by 257 · see citing works

Total homocysteine and cardiovascular disease

Nygard, O. K., Vollset, S. E., Refsum, H., Brattström, L. E., & Ueland, P. M. (1999) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1999.00512.x · Cited by 256 · see citing works

DACH-LIGA Homocystein (German, Austrian and Swiss Homocysteine Society): Consensus Paper on the Rational Clinical Use of Homocysteine, Folic Acid and B-Vitamins in Cardiovascular and Thrombotic Diseases: Guidelines and Recommendations

Stanger, O., Herrmann, W., Pietrzik, K. F., Fowler, B., Geisel, J., Dierkes, J., & Weger, M. (2003) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2003.214 · Cited by 254 · see citing works

Vascular Outcome in Patients With Homocystinuria due to Cystathionine β-Synthase Deficiency Treated Chronically

Yap, S., Boers, G. H. J., Wilcken, B. M., Wilcken, D. E. L., Brenton, D. P., Lee, P., Walter, J. H., Howard, P. M., & Naughten, E. R. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1201.100225 · Cited by 254 · see citing works

Homocysteine and cognitive function in the elderly: The Rotterdam Scan Study

Prins, N. D., den Heijer, T., Hofman, A., Koudstaal, P. J., Jolles, J., Clarke, R., & Breteler, M. M. B. (2002) · Neurology · doi:10.1212/01.wnl.0000032494.05619.93 · Cited by 254 · see citing works

Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey

Jacques, P. F., Rosenberg, I. H., Rogers, G. T., Selhub, J., Bowman, B. A., Gunter, E. W., Wright, J. D., & Johnson, C. L. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.3.482 · Cited by 250 · see citing works

Enzyme conversion immunoassay for determining total homocysteine in plasma or serum

Frantzen, F., Faaren, A. L., Alfheim, I., & Nordhei, A. K. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.2.311 · Cited by 248 · see citing works

Homocysteine and methylmalonic acid: Markers to predict and avoid toxicity from pemetrexed therapy

Niyikiza, C., Baker, S. D., Seitz, D. E., Walling, J. M., Nelson, K., Rusthoven, J. J., Stabler, S. P., Paoletti, P., Calvert, A. H., & Allen, R. H. (2002) · PubMed · doi:10.25405/ncl.34649535 · Cited by 248 · see citing works

The effect of a subnormal vitamin B-6 status on homocysteine metabolism.

Ubbink, J., van der Merwe, A., Delport, R., Allen, R. H., Stabler, S. P., Riezler, R., & Vermaak, W. J. H. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118763 · Cited by 246 · see citing works

Homocysteine, B vitamin status, and cognitive function in the elderly

Duthie, S. J., Whalley, L. J., Collins, A. R., Leaper, S., Berger, K., & Deary, I. J. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.5.908 · Cited by 244 · see citing works

Changes in homocysteine levels during normal pregnancy

WALKER, M. C., Smith, G. N., Perkins, S. L., et al. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70269-3 · Cited by 239 · see citing works

Hyperhomocysteinemia in Chronic Renal Disease

Bostom, A. G., & Culleton, B. F. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v104891 · Cited by 237 · see citing works

Age- and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation

Rasmussen, K. D., Møller, J., Lyngbak, M., PEDERSEN, A. M., & Dybkjær, L. (1996) · Clinical Chemistry · doi:10.1093/clinchem/42.4.630 · Cited by 236 · see citing works

Homocysteine species as components of plasma redox thiol status

Ueland, P. M. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.3.340 · Cited by 236 · see citing works

Screening for vitamin B-12 and folate deficiency in older persons

Clarke, R., Refsum, H., Birks, J., Evans, J. G., Johnston, C., Sherliker, P., Ueland, P. M., Schneede, J., McPartlin, J. M., Nexø, E., et al. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.5.1241 · Cited by 235 · see citing works

Hyperhomocysteinemia: a risk factor for placental abruption or infarction

Goddijn-Wessel, T. A. W., Wouters, M. G. A. J., van der Molen, E. F., Spuijbroek, M. D. E. H., Steegers‐Theunissen, R. P. M., Blom, H. J., Boers, G. H. J., & Eskes, T. K. A. B. (1996) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0301-2115(96)02383-4 · Cited by 233 · see citing works

Riboflavin as a Determinant of Plasma Total Homocysteine: Effect Modification by the Methylenetetrahydrofolate Reductase C677T Polymorphism

Hustad, S., Ueland, P. M., Vollset, S. E., Zhang, Y., Bjørke‐Monsen, A. L., & Schneede, J. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.8.1065 · Cited by 232 · see citing works

Staging vitamin B−12 (cobalamin) status in vegetarians

Herbert, V. D. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/59.5.1213s · Cited by 224 · see citing works

Coffee consumption and plasma total homocysteine: The Hordaland Homocysteine Study

Nygard, O. K., Refsum, H., Ueland, P. M., Stensvold, I., Je, N., Kvåle, G., & Vollset, S. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.1.136 · Cited by 220 · see citing works

Plasma Homocysteine in the Acute and Convalescent Phases After Stroke

Lindgren, A. G., Brattström, L. E., Norrving, B. G., Hultberg, B. L., Andersson, A. D. R., & Johansson, B. B. (1995) · Stroke · doi:10.1161/01.str.26.5.795 · Cited by 216 · see citing works

Homocysteine and Its Disulfide Derivatives

Mudd, S. H., Finkelstein, J. D., Refsum, H., Ueland, P. M., Malinow, M. R., Lentz, S. R., Jacobsen, D. W., Brattström, L. E., Wilcken, B., Wilcken, D. E. L., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.7.1704 · Cited by 215 · see citing works

Preventive health care

Patterson, C., & Chambers, L. W. (1995) · The Lancet · doi:10.1016/s0140-6736(95)90119-1 · Cited by 212 · see citing works

Homocysteine and Cognitive Decline in Healthy Elderly

McCaddon, A., Hudson, P. R., Davies, G. K., Hughes, A., Williams, J. H. H., & Wilkinson, C. (2001) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051275 · Cited by 206 · see citing works

Plasma total homocysteine and cardiovascular and noncardiovascular mortality: the Hordaland Homocysteine Study

Vollset, S. E., Refsum, H., Tverdal, A., Nygard, O. K., Nordrehaug, J. E., Tell, G. S., & Ueland, P. M. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.1.130 · Cited by 205 · see citing works

Endothelial Dysfunction and Elevation of S -Adenosylhomocysteine in Cystathionine β-Synthase–Deficient Mice

Dayal, S., Bottiglieri, T., Arning, E., Maeda, N., Malinow, M. R., Sigmund, C. D., Heistad, D. D., Faraci, F. M., & Lentz, S. R. (2001) · Circulation Research · doi:10.1161/hh1101.092180 · Cited by 205 · see citing works

Depression and Folate Status in the US Population

Morris, M. S., D, M. F. M., Jacques, P. F., Selhub, J., & Rosenberg, I. H. (2003) · Psychotherapy and Psychosomatics · doi:10.1159/000068692 · Cited by 202 · see citing works

Randomized Trial of Folic Acid Supplementation and Serum Homocysteine Levels

Wald, D. S., Bishop, L., Wald, N., Law, M., Hennessy, E., Weir, D. G., McPartlin, J., & Scott, J. M. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.5.695 · Cited by 201 · see citing works

Lifestyle Factors and Plasma Homocysteine Concentrations in a General Population Sample

de Bree, A. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.2.150 · Cited by 200 · see citing works

Fully automated fluorescence assay for determining total homocysteine in plasma.

Refsum, H., Ueland, P. M., & Svardal, A. M. (1989) · Clinical Chemistry · doi:10.1093/clinchem/35.9.1921 · Cited by 197 · see citing works

Effects of Sex Steroids on Plasma Total Homocysteine Levels: A Study in Transsexual Males and Females

Giltay, E. J., Hoogeveen, E. K., Elbers, J. M. H., Gooren, L. J., Asscheman, H., & Stehouwer, C. D. A. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.2.4574 · Cited by 193 · see citing works

Plasma Concentrations of Homocysteine and Other Aminothiol Compounds Are Related to Food Intake in Healthy Human Subjects

Guttormsen, A. B., Schneede, J., Fiskerstrand, T., Ueland, P. M., & Refsum, H. M. (1994) · Journal of Nutrition · doi:10.1093/jn/124.10.1934 · Cited by 191 · see citing works

Elevated plasma homocysteine in early pregnancy: A risk factor for the development of severe preeclampsia

Cotter, A. M., Molloy, A. M., Scott, J. M., et al. (2001) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2001.117304 · Cited by 190 · see citing works

Teratogen update: thalidomide: a review, with a focus on ocular findings and new potential uses

Miller, M. T., & Str�mland, K. (1999) · Teratology · doi:10.1002/(sici)1096-9926(199911)60:5 · Cited by 187 · see citing works

C677T and A1298C Polymorphisms of the Methylenetetrahydrofolate Reductase Gene: Incidence and Effect of Combined Genotypes on Plasma Fasting and Post-Methionine Load Homocysteine in Vascular Disease

Hanson, N. Q., Aras, Ö., Yang, F. J., et al. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.4.661 · Cited by 187 · see citing works

Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate

Stead, L. M., Au, K. P., Jacobs, R. L., Brosnan, M. E., & Brosnan, J. T. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.5.e1095 · Cited by 187 · see citing works

Is Metabolic Evidence for Vitamin B-12 and Folate Deficiency More Frequent in Elderly Patients With Alzheimer's Disease?

Joosten, E., Lesaffre, E. M. E. H., Riezler, R., Ghekiere, V., Dereymaeker, L., Pelemans, W., & Dejaeger, E. W. (1997) · The Journals of Gerontology Series A · doi:10.1093/gerona/52a.2.m76 · Cited by 187 · see citing works

Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey

Morris, M. S., Jacques, P. F., Rosenberg, I. H., & Selhub, J. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.5.927 · Cited by 186 · see citing works

Elevated Plasma Homocysteine in Alcoholics

Hultberg, B. L., Berglund, M., Andersson, A. D. R., et al. (1993) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1993.tb00820.x · Cited by 182 · see citing works

Vitamin Supplements and Cardiovascular Risk: Review of the Randomized Trials of Homocysteine-Lowering Vitamin Supplements

Clarke, R., & ARMITAGE, J. (2000) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2000-8101 · Cited by 177 · see citing works

Sulphur containing amino acids in chronic renal failure with particular reference to homocystine and cysteine‐homocysteine mixed disulphide

Wilcken, D. E. L., & Gupta, V. J. (1979) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1979.tb00888.x · Cited by 169 · see citing works

Post-methionine load hyperhomocysteinemia in persons with normal fasting total plasma homocysteine: initial results from The NHLBI Family Heart Study

Bostom, A. G., Jacques, P. F., Nadeau, M., Williams, R. R., Ellison, R. C., & Selhub, J. (1995) · Atherosclerosis · doi:10.1016/0021-9150(95)05529-6 · Cited by 168 · see citing works

Cobalamin and folate deficiency: acquired and hereditary disorders in children.

Rosenblatt, D. S., & Whitehead, V. M. (1999) · PubMed · Cited by 163 · see citing works

Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements

McNulty, H., McKinley, M. C., Wilson, B., et al. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.2.436 · Cited by 163 · see citing works

Elevated Plasma Homocysteine Levels in Patients Treated With Levodopa

Rogers, J., Sanchez-Saffon, A., Frol, A. B., & Diaz-Arrastia, R. R. (2003) · Archives of Neurology · doi:10.1001/archneur.60.1.59 · Cited by 160 · see citing works

Plasma Homocysteine Levels, Cerebrovascular Risk Factors, and Cerebral White Matter Changes (Leukoaraiosis) in Patients With Alzheimer Disease

Hogervorst, E. (2002) · Archives of Neurology · doi:10.1001/archneur.59.5.787 · Cited by 158 · see citing works

Total Homocysteine and Estrogen Status Indicators in the Third National Health and Nutrition Examination Survey

Morris, M. S., Jacques, P. F., Selhub, J., & Rosenberg, I. H. (2000) · American Journal of Epidemiology · doi:10.1093/aje/152.2.140 · Cited by 154 · see citing works

Preconception homocysteine and B vitamin status and birth outcomes in Chinese women

Ronnenberg, A. G., GOLDMAN, M. B., Chen, D., et al. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.6.1385 · Cited by 153 · see citing works

Effect of l -dopa on plasma homocysteine in PD patients

Miller, J. W., Selhub, J., Nadeau, M. R., Thomas, C. A., Feldman, R. G., & Wolf, P. A. (2003) · Neurology · doi:10.1212/01.wnl.0000055899.24594.8e · Cited by 152 · see citing works

Homocystinuria due to cystathionine β‐synthase deficiency in Ireland: 25 years' experience of a newborn screened and treated population with reference to clinical outcome and biochemical control

Yap, S., & Naughten, E. R. (1998) · Journal of Inherited Metabolic Disease · doi:10.1023/a:1005445132327 · Cited by 150 · see citing works

Hyperhomocysteinaemia—a common finding in a psychogeriatric population

Nilsson, K. H., Gustafson, L., Fäldt, R., Andersson, A. D. R., Brattström, L. E., Lindgren, A. G., Israelsson, B., & Hultberg, B. L. (1996) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1996.tb02129.x · Cited by 150 · see citing works

Elevated Homocysteine Levels in Young Male Patients With Schizophrenia

Levine, J., Stahl, Z., Sela, B. A., Gavendo, S., Ruderman, V., & Belmaker, R. H. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1790 · Cited by 150 · see citing works

Vitamins and progression of atherosclerosis in hyper-homocyst(e)inaemia

Spence, J. D., & Peterson, J. C. (1998) · The Lancet · doi:10.1016/s0140-6736(05)78275-1 · Cited by 149 · see citing works

Total homocysteine measurement in clinical practice

Rasmussen, K., & Møller, J. (2000) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/0004563001899915 · Cited by 148 · see citing works

Nutrition and depression: focus on folate

Alpert, J. E., Mischoulon, D., Nierenberg, A. A., & D, M. F. M. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00327-0 · Cited by 148 · see citing works

Unfiltered coffee increases plasma homocysteine concentrations in healthy volunteers: a randomized trial

Grubben, M. J. A. L., Boers, G. H. J., Blom, H. J., Broekhuizen, R., de Jong, R. D. J., van Rijt, L. S., de Ruijter, E., Swinkels, D. W., Nagengast, F. M., & Katan, M. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.480 · Cited by 147 · see citing works

Homocysteine and methylmalonic acid in diagnosis and risk assessment from infancy to adolescence

Bjørke Monsen, A. L., & Ueland, P. M. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.1.7 · Cited by 144 · see citing works

Plasma total homocysteine levels in hyperthyroid and hypothyroid patients

Nedrebø, B. G., Ericsson, U.-B. C., Nygard, O. K., et al. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90198-6 · Cited by 143 · see citing works

Plasma total homocysteine in a representative sample of 972 British men and women aged 65 and over

Bates, C., Mansoor, M., van der Pols, J. C., Prentice, A., Cole, T. J., & Finch, S. (1997) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600468 · Cited by 142 · see citing works

Nitrous Oxide-Induced Increased Homocysteine Concentrations Are Associated with Increased Postoperative Myocardial Ischemia in Patients Undergoing Carotid Endarterectomy

Badner, N. H., Beattie, W. S., Freeman, D. J., & Spence, J. D. (2000) · Anesthesia & Analgesia · doi:10.1097/00000539-200011000-00006 · Cited by 142 · see citing works

Increased levels of plasma homocysteine are associated with nephropathy, but not severe retinopathy in type 1 diabetes mellitus

Hultberg, B., Agardh, E., Andersson, A. D. R., Brattström, L. E., Isaksson, A., Israelsson, B., & Agardh, C. D. (1991) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519109091615 · Cited by 139 · see citing works

Three Different Methods for the Determination of Total Homocysteine in Plasma

TePoele‐Pothoff, M. T. W. B., van den Berg, M., Franken, D. G., Boers, G. H. J., Jakobs, C., de Kroon, I. F. I., Eskes, T. K. A. B., Trijbels, J. M. F., & Blom, H. J. (1995) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456329503200218 · Cited by 139 · see citing works

Variability and determinants of total homocysteine concentrations in plasma in an elderly population

Clarke, R., Woodhouse, P. R., Ulvik, A., Frost, C. D., Sherliker, P., Refsum, H., Ueland, P. M., & Khaw, K. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.1.102 · Cited by 139 · see citing works

Vitamin B-12 deficiency and malabsorption are highly prevalent in rural Mexican communities

Allen, L., Rosado, J. L., Casterline, J. E., Martı́nez, H., Lopez, P., Muñoz, E., & Black, A. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.5.1013 · Cited by 138 · see citing works

The pregnancy-related decrease in fasting plasma homocysteine is not explained by folic acid supplementation, hemodilution, or a decrease in albumin in a longitudinal study

Murphy, M. M., Scott, J. M., McPartlin, J. M., & Fernandez-Ballart, J. D. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.3.614 · Cited by 136 · see citing works

Association between B vitamin intake and plasma homocysteine concentration in the general Dutch population aged 20–65 y

de Bree, A., Verschuren, W. M. M., Blom, H. J., et al. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.6.1027 · Cited by 136 · see citing works

Plasma homocysteine in children with acute lymphoblastic leukemia: changes during a chemotherapeutic regimen including methotrexate.

Refsum, H., Wesenberg, F., & Ueland, P. M. (1991) · PubMed · Cited by 135 · see citing works

Folic Acid Supplementation and Prevention of Birth Defects

Green, N. (2002) · Journal of Nutrition · doi:10.1093/jn/132.8.2356s · Cited by 135 · see citing works

The effect of blood sample aging and food consumption on plasma total homocysteine levels

Ubbink, J., Vermaak, W. J. H., van der Merwe, A., & Becker, P. (1992) · Clinica Chimica Acta · doi:10.1016/0009-8981(92)90155-j · Cited by 131 · see citing works

Diagnosis of cobalamin deficiency [letter; comment]

Griffiths, A. (1991) · Blood · doi:10.1182/blood.v77.8.1853.bloodjournal7781853 · Cited by 130 · see citing works

Nonfasting Plasma Total Homocysteine Level and Mortality in Middle-Aged and Elderly Men and Women in Jerusalem

Kark, J. D., Selhub, J., Adler, B., Gofin, J., Abramson, J. H., Friedman, G., & Rosenberg, I. H. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-131-5-199909070-00002 · Cited by 129 · see citing works

Plasma homocysteine concentration predicts mortality in non-insulin-dependent diabetic patients with and without albuminuria

Stehouwer, C. D. A., Gall, M.-A., Hougaard, P., et al. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00256.x · Cited by 128 · see citing works

Direct Assay for Cobalamin Bound to Transcobalamin (Holo-Transcobalamin) in Serum

Ulleland, M., Eilertsen, I., Quadros, E. V., et al. (2002) · Clinical Chemistry · doi:10.1093/clinchem/48.3.526 · Cited by 127 · see citing works

Homocysteine and cardiovascular disease in diabetes mellitus

Audelin, M. C., & Genest, J. J. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00531-7 · Cited by 124 · see citing works

Effect of High Dose Folic Acid Therapy on Hyperhomocysteinemia in Hemodialysis Patients

Sunder–Plassmann, G., Diaeresis]DINGER, M. F., Buchmayer, H., Papagiannopoulos, M., Wojcik, J., Kletzmayr, J., Enzenberger, B., Janata, O., Winkelmayer­, W. C., Paul, G., et al. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1161106 · Cited by 124 · see citing works

Homocysteine Export from Erythrocytes and Its Implication for Plasma Sampling

Andersson, A. D. R., Isaksson, A., & Hultberg, B. (1992) · Clinical Chemistry · doi:10.1093/clinchem/38.7.1311 · Cited by 120 · see citing works

Fasting plasma homocysteine as a sensitive parameter of antifolate effect: A study of psoriasis patients receiving low-dose methotrexate treatment

Refsum, H., Helland, S., & Ueland, P. M. (1989) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1989.179 · Cited by 116 · see citing works

Plasma Total Homocysteine, Pregnancy Complications, and Adverse Pregnancy Outcomes: The Hordaland Homocysteine Study

Vollset, S. E., Refsum, H., Irgens, L. M., Emblem, B. M., Tverdal, A., Gjessing, H. K. K., Monsen, A. L. B. R., & Ueland, P. M. (2000) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-200010000-00002 · Cited by 116 · see citing works

Quantification of Holo-Transcobalamin, a Marker of Vitamin B12 Deficiency

Nexø, E., Christensen, A.-L., Hvas, A., et al. (2002) · Clinical Chemistry · doi:10.1093/clinchem/48.3.561 · Cited by 115 · see citing works

Screening the Older Population for Cobalamin (Vitamin B 12 ) Deficiency

Stabler, S. P. (1995) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1995.tb07408.x · Cited by 114 · see citing works

Hyperhomocysteinemia and vitamin B-12 deficiency in elderly using Title IIIc nutrition services

Johnson, M. A., Hawthorne, N. A., Brackett, W. R., et al. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.1.211 · Cited by 110 · see citing works

Results of B-vitamin supplementation study used in a prediction model to define a reference range for plasma homocysteine

Ubbink, J., Becker, P., Vermaak, W. J. H., & Delport, R. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.7.1033 · Cited by 110 · see citing works

Plasma levels of the atherogenic amino acid homocysteine in postmenopausal women with breast cancer treated with tamoxifen

Anker, G. B., Lønning, P. E., Ueland, P. M., Refsum, H., & Lien, E. A. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910600316 · Cited by 110 · see citing works

Methods for homocysteine analysis and biological relevance of the results

Ducros, V., Demuth, K., Sauvant‐Rochat, M., Quillard‐Muraine, M., Caussé, E., Candito, M., Read, M., Drai, J., Garcia, I., & Gerhardt, M.-F. (2002) · Journal of Chromatography B · doi:10.1016/s1570-0232(02)00497-x · Cited by 109 · see citing works

Nitric Oxide Inhibits Methionine Synthase Activity in Vivo and Disrupts Carbon Flow through the Folate Pathway

Danishpajooh, I. O., Gudi, T., Chen, Y., Kharitonov, V. G., Sharma, V. S., & Boss, G. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104043200 · Cited by 108 · see citing works

Homocysteine levels and decline in physical function: MacArthur studies of successful aging

Kado, D. M., Bucur, A., Selhub, J., Rowe, J. W., & Seeman, T. E. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01269-x · Cited by 107 · see citing works

Relation of Total Homocysteine and Lipid Levels in Children to Premature Cardiovascular Death in Male Relatives

Tonstad, S., Refsum, H., Sivertsen, M., Christophersen, B. O., Ose, L., & Ueland, P. M. (1996) · Pediatric Research · doi:10.1203/00006450-199607000-00009 · Cited by 107 · see citing works

Folic acid supplements during pregnancy and risk of miscarriage

Gindler, J., Li, Z., Berry, R., Zheng, J.-C., Correa, A., Sun, X.-M., Wong, L.-Y., Cheng, L.-C., Erickson, J. D., Wang, Y., et al. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05969-4 · Cited by 107 · see citing works

Determinants of changes in plasma homocysteine in hyperthyroidism and hypothyroidism

Diekman, M. J. M., van der Put, N. M. J., Blom, H. J., Tijssen, J. G. P., & Wiersinga, W. M. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01170.x · Cited by 104 · see citing works

Lipid-lowering drugs and homocysteine

de Lorgeril, M., Salen, P., Paillard, F., Lacan, P., & Richard, G. J. (1999) · The Lancet · doi:10.1016/s0140-6736(05)77220-2 · Cited by 102 · see citing works

Power Shortage: Clinical Trials Testing the “Homocysteine Hypothesis” against a Background of Folic Acid–Fortified Cereal Grain Flour

Bostom, A. G., Selhub, J., Jacques, P. F., & Rosenberg, I. H. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-135-2-200107170-00014 · Cited by 101 · see citing works

Cobalamin Deficiency in General Practice. Assessment of the Diagnostic Utility and Cost-Benefit Analysis of Methylmalonic Acid Determination in Relation to Current Diagnostic Strategies

Hølleland, G., Schneede, J., Ueland, P. M., Lund, P. K., Refsum, H., & Sandberg, S. (1999) · Clinical Chemistry · doi:10.1093/clinchem/45.2.189 · Cited by 100 · see citing works

Relationship between plasma homocysteine and vitamin status in the Framingham study population. Impact of folic acid fortification.

Selhub, J., Jacques, P. F., Bostom, A. G., Wilson, P. W., & Rosenberg, I. H. (2000) · PubMed · Cited by 99 · see citing works

N-acetylcysteine treatment lowers plasma homocysteine but not serum lipoprotein(a) levels

Wiklund, O., Fager, G., Andersson, A. D. R., Lundstam, U., Masson, P., & Hultberg, B. L. (1996) · Atherosclerosis · doi:10.1016/0021-9150(95)05635-1 · Cited by 96 · see citing works

Folates and prevention of disease

Molloy, A. M., & Scott, J. M. (2001) · Public Health Nutrition · doi:10.1079/phn2001144 · Cited by 96 · see citing works

Second-trimester plasma homocysteine levels and pregnancy-induced hypertension, preeclampsia, and intrauterine growth restriction

Hogg, B. B., Tamura, T., Johnston, K. E., DuBard, M. B., & Goldenberg, R. L. (2000) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2000.109044 · Cited by 95 · see citing works

Evaluation of Novel Assays in Clinical Chemistry: Quantification of Plasma Total Homocysteine

Nexø, E., Engbaek, F., Ueland, P. M., et al. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.8.1150 · Cited by 94 · see citing works

Association of folate intake and serum homocysteine in elderly persons according to vitamin supplementation and alcohol use

Koehler, K. M., Baumgartner, R., Garry, P. J., Allen, R. H., Stabler, S. P., & Rimm, E. B. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.3.628 · Cited by 93 · see citing works

Plasma Total Homocysteine and Cognitive Performance in a Volunteer Elderly Population

Budge, M. M., Johnston, C., Hogervorst, E., de Jager, C., MILWAIN, E., Iversen, S. D., Barnetson, L. P. D., Budge, M. M., KING, E., & Smith, A. D. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06392.x · Cited by 93 · see citing works

Homocysteine metabolism in renal failure

van Guldener, C., Stam, F., & Stehouwer, C. D. A. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.59780234.x · Cited by 92 · see citing works

Monitoring cobalamin inactivation during nitrous oxide anesthesia by determination of homocysteine and folate in plasma and urine

Ermens, A. A. M., Refsum, H., Rupreht, J., Spijkers, L. J. M., Guttormsen, A. B., Lindemans, J. W., Ueland, P. M., & Abels, J. (1991) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1991.45 · Cited by 91 · see citing works

Factors explaining the difference of total homocysteine between men and women in the European Investigation Into Cancer and Nutrition Potsdam study

Dierkes, J., Jeckel, A., Ambrosch, A., et al. (2001) · Metabolism · doi:10.1053/meta.2001.23286 · Cited by 91 · see citing works

Assessment of homocysteine status

Refsum, H., Fiskerstrand, T., Guttormsen, A. B., et al. (1997) · Journal of Inherited Metabolic Disease · doi:10.1023/a:1005321225893 · Cited by 91 · see citing works

Folate for depressive disorders

Taylor, M. J., Carney, S. M., Geddes, J. R., & Goodwin, G. M. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003390 · Cited by 90 · see citing works

Total homocyst(e)ine in plasma and amniotic fluid of pregnant women

Kang, S., WONG, P. W. K., Zhou, J., et al. (1986) · Metabolism · doi:10.1016/0026-0495(86)90049-1 · Cited by 90 · see citing works

Elevated Second-Trimester Serum Homocyst(e)ine Levels and Subsequent Risk of Preeclampsia

Sorensen, T. K., Malinow, M. R., Williams, M. A., King, I. B., & Luthy, D. A. (1999) · Gynecologic and Obstetric Investigation · doi:10.1159/000010148 · Cited by 89 · see citing works

Effective homocysteine metabolism may protect South African blacks against coronary heart disease

Ubbink, J. B., Vermaak, W. J. H., Delport, R., van der Merwe, A., Becker, P., & Potgieter, H. C. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.4.802 · Cited by 89 · see citing works

Holo-Transcobalamin Is an Early Marker of Changes in Cobalamin Homeostasis. A Randomized Placebo-controlled Study

Nexø, E., Hvas, A., Bleie, Ø., et al. (2002) · Clinical Chemistry · doi:10.1093/clinchem/48.10.1768 · Cited by 86 · see citing works

Hyperhomocysteinemia, Vascular Function and Atherosclerosis: Effects of Vitamins

Haynes, W. G. (2002) · Cardiovascular Drugs and Therapy · doi:10.1023/a:1022130217463 · Cited by 85 · see citing works

Correlates of plasma homocysteine, cysteine and cysteinyl-glycine in respondents in the British National Diet and Nutrition Survey of Young People Aged 4–18 Years, and a comparison with the Survey of People Aged 65 Years and Over

Bates, C. J., Mansoor, M. A., Gregory, J., Pentieva, K. D., & Prentice, A. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2001479 · Cited by 85 · see citing works

Low vitamin B-12 status in confirmed Alzheimer's disease as revealed by serum holotranscobalamin

Refsum, H. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.7.959 · Cited by 85 · see citing works

Assessment of vitamin B-12, folate, and vitamin B-6 status and relation to sulfur amino acid metabolism in neonates

Minet, J.-C., Bissé, E., Aebischer, C. P., Beil, A., Wieland, H., & Lütschg, J. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.751 · Cited by 84 · see citing works

Plasma Homocysteine Concentrations in the Acute and Convalescent Periods of Atherothrombotic Stroke

Meiklejohn, D. J., Vickers, M. A., Dijkhuisen, R., et al. (2001) · Stroke · doi:10.1161/01.str.32.1.57 · Cited by 84 · see citing works

Maternal and fetal plasma homocysteine concentrations at birth: The influence of folate, vitamin B12, and the 5,10-methylenetetrahydrofolate reductase 677C→T variant

Molloy, A. M., Mills, J. L., McPartlin, J. M., Kirke, P. N., Scott, J. M., & Daly, S. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.121105 · Cited by 84 · see citing works

How to diagnose cobalamin deficiency

Nexø, E., Hansen, M., Rasmussen, K., Lindgren, A., & Gräsbeck, R. (1994) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519409088580 · Cited by 83 · see citing works

Vitamin B12 deficiency

Green, R., Allen, L. H., Bjørke-Monsen, A.-L., Brito, A., Guéant, J.-L., Miller, J. W., Molloy, A. M., Nexo, E., Stabler, S., Toh, B.-H., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.40 · Cited by 970 · see citing works

Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial

Smith, A. D., Smith, S. M., de Jager, C. A., Whitbread, P., Johnston, C., Agacinski, G., Oulhaj, A., Bradley, K. M., Jacoby, R., & Refsum, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012244 · Cited by 813 · see citing works

Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: A randomised, double blind, controlled trial

Durga, J., van Boxtel, M. P., Schouten, E. G., Kok, F. J., Jolles, J., Katan, M. B., & Verhoef, P. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60109-3 · Cited by 758 · see citing works

Homocysteine and folate metabolism in depression

Bottiglieri, T. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.06.021 · Cited by 459 · see citing works

Homocysteine and folate as risk factors for dementia and Alzheimer disease

Ravaglia, G., Forti, P., Maioli, F., Martelli, M., Servadei, L., Brunetti, N., Porcellini, E., & Licastro, F. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.3.636 · Cited by 500 · see citing works

Homocysteine-lowering therapy: a role in stroke prevention?

Spence, J. D. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70219-3 · Cited by 220 · see citing works

Blood inflammatory markers and risk of dementia: The Conselice Study of Brain Aging

Ravaglia, G., Forti, P., Maioli, F., Chiappelli, M., Montesi, F., Tumini, E., Mariani, E., Licastro, F., & Patterson, C. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.08.012 · Cited by 198 · see citing works

The role of hyperhomocysteinemia as well as folate, vitamin B6 and B12 deficiencies in osteoporosis – a systematic review

Herrmann, M., Peter Schmidt, J., Umanskaya, N., Wagner, A., Taban-Shomal, O., Widmann, T., Colaianni, G., Wildemann, B., & Herrmann, W. (2007) · Clinical Chemical Laboratory Medicine · doi:10.1515/cclm.2007.362 · Cited by 124 · see citing works

Homocysteine and Cognitive Function in a Population‐Based Study of Older Adults

Schafer, J. H., Glass, T. A., Bolla, K. I., Mintz, M., Jedlicka, A. E., & Schwartz, B. S. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53153.x · Cited by 124 · see citing works

Homocysteine and holotranscobalamin and the risk of Alzheimer disease: A longitudinal study

Hooshmand, B., Solomon, A., Kåreholt, I., Leiviskä, J., Rusanen, M., Ahtiluoto, S., Winblad, B., Laatikainen, T., Soininen, H., & Kivipelto, M. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f88162 · Cited by 122 · see citing works

Metabolic effects of low glycaemic index diets

Radulian, G., Rusu, E., Dragomir, A., & Posea, M. (2009) · Nutrition Journal · doi:10.1186/1475-2891-8-5 · Cited by 119 · see citing works

Homocysteine, folate, and vitamin B-12 and cognitive performance in older Chinese adults: findings from the Singapore Longitudinal Ageing Study

Feng, L., Ng, T.-P., Chuah, L., Niti, M., & Kua, E.-H. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.6.1506 · Cited by 98 · see citing works

Vitamin B-12 status in infancy is positively associated with development and cognitive functioning 5 y later in Nepalese children

Kvestad, I., Hysing, M., Shrestha, M., Ulak, M., Thorne-Lyman, A. L., Henjum, S., Ueland, P. M., Midttun, Ø., Fawzi, W., Chandyo, R. K., et al. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.144931 · Cited by 92 · see citing works

Association of maternal vitamin B12 and folate levels in early pregnancy with gestational diabetes: a prospective UK cohort study (PRiDE study)

Saravanan, P., Sukumar, N., Adaikalakoteswari, A., Goljan, I., Venkataraman, H., Gopinath, A., Bagias, C., Yajnik, C. S., Stallard, N., Ghebremichael-Weldeselassie, Y., et al. (2021) · Diabetologia · doi:10.1007/s00125-021-05510-7 · Cited by 91 · see citing works

Meta-analysis of the relationship between homocysteine, vitamin B12, folate, and multiple sclerosis

Zhu, Y., He, Z.-Y., & Liu, H.-N. (2011) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2010.12.022 · Cited by 75 · see citing works

The effect of B-vitamins on biochemical bone turnover markers and bone mineral density in osteoporotic patients: a 1-year double blind placebo controlled trial

Herrmann, M., Umanskaya, N., Traber, L., Schmidt-Gayk, H., Menke, W., Lanzer, G., Lenhart, M., Peter Schmidt, J., & Herrmann, W. (2007) · Clinical Chemical Laboratory Medicine · doi:10.1515/cclm.2007.352 · Cited by 55 · see citing works

Plasma homocysteine and vitamin B12 serum levels, red blood cell folate concentrations, C677T methylenetetrahydrofolate reductase gene mutation and risk of recurrent miscarriage: a case-control study in Spain

Creus, M., Deulofeu, R., Peñarrubia, J., Carmona, F., & Balasch, J. (2013) · Clinical Chemistry and Laboratory Medicine · doi:10.1515/cclm-2012-0452 · Cited by 37 · see citing works

Homocysteine Levels in Chronic Gastritis and Other Conditions: Relations to Incident Cardiovascular Disease and Dementia

Redéen, S., Ryberg, A., Petersson, F., Eriksson, O., Nägga, K., & Borch, K. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-009-0761-0 · Cited by 26 · see citing works

Plasma homocysteine in relation to serum cobalamin and blood folate in a psychogeriatric population

Nilsson, K. H., Gustafson, L., Fäldt, R., et al. (1994) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1994.tb01111.x · Cited by 71 · see citing works

Body composition in patients with classical homocystinuria: body mass relates to homocysteine and choline metabolism

Poloni, S., Leistner‐Segal, S., Bandeira, I. C., D’Almeida, V., de Souza, C. F. M., Spritzer, P. M., Castro, K., Tonon, T., Nalin, T., Imbard, A., et al. (2014) · Gene · doi:10.1016/j.gene.2014.05.015 · Cited by 21 · see citing works

Homocysteine and cysteine loads in patients with homocystinuria due to cystathionine synthase deficiency: Effects of vitamin B-6

Rassin, D. K., Longhi, R. C., Sternowsky, H. J., et al. (1977) · Clinica Chimica Acta · doi:10.1016/0009-8981(77)90478-8 · Cited by 8 · see citing works

Health Functionalities of Betaine in Patients With Homocystinuria

Truitt, C., Hoff, W. D., & Deole, R. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.690359 · Cited by 23 · see citing works

Relationship between Homocysteine and Superoxide Dismutase in Homocystinuria : Possible Relevance to Cardiovascular Risk.

Wilcken, D. E. L., Wang, X. L., Adachi, T., et al. (2001) · Institutional Repositories DataBase (IRDB) · Cited by 5 · see citing works