The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Development and validation of sensitive method for determination of serum cotinine in smokers and nonsmokers by liquid chromatography/atmospheric pressure ionization tandem mass spectrometry
Abstract
We describe a sensitive and specific method for measuring cotinine in serum by HPLC coupled to an atmospheric pressure chemical ionization tandem mass spectrometer. This method can analyze 100 samples/day on a routine basis, and its limit of detection of 50 ng/L makes it applicable to the analysis of samples from nonsmokers potentially exposed to environmental tobacco smoke. Analytical accuracy has been demonstrated from the analysis of NIST cotinine standards and from comparative analyses by both the current method and gas chromatography/high-resolution mass spectrometry. Precision has been examined through the repetitive analysis of a series of bench and blind QC materials. This method has been applied to the analysis of cotinine in serum samples collected as part of the Third National Health and Nutrition Examination Survey (NHANES III).
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Cites
Comparison of tests used to distinguish smokers from nonsmokers
Jarvis, M. J., Tunstall-Pedoe, H., Feyerabend, C., Vesey, C., & Saloojee, Y. (1987) · American Journal of Public Health · doi:10.2105/ajph.77.11.1435 · Cited by 994 · cited 1×
“The highest serum cotinine concentration that would be expected in a nonsmoker exposed to ETS is �10–13 �g/L [37, 38], whereas most active smokers have serum cotinine con centrations considerably �25 �g/L.”
BackgroundNicotine and cotinine elimination pharmacokinetics in smokers and nonsmokers
Benowitz, N. L., & Jacob III, P. (1993) · Clinical Pharmacology and Therapeutics · doi:10.1038/clpt.1993.27 · Cited by 232 · cited 2×
“By contrast, cotinine has a much longer half-life of �18 –20 h, making it more appropriate for use as an exposure marker [7].”
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Cited by
Perera, F. P., Rauh, V., Tsai, W.-Y., Kinney, P., Camann, D., Barr, D., Bernert, T., Garfinkel, R., Tu, Y.-H., Diaz, D., et al. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.5742 · Cited by 625
Schleicher, R. L., Carroll, M. D., Ford, E. S., & Lacher, D. A. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27016 · Cited by 504
Exposure to environmental tobacco smoke and cognitive abilities among u.S. Children and adolescents
Yolton, K., Dietrich, K., Auinger, P., Lanphear, B. P., & Hornung, R. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7210 · Cited by 331
Urinary Cadmium, Impaired Fasting Glucose, and Diabetes in the NHANES III
Schwartz, G. G., Il’yasova, D., & Ivanova, A. (2003) · Diabetes Care · doi:10.2337/diacare.26.2.468 · Cited by 295
Dietz, P. M., Homa, D., England, L. J., Burley, K., Tong, V. T., Dube, S. R., & Bernert, J. T. (2011) · American Journal of Epidemiology · doi:10.1093/aje/kwq381 · Cited by 276
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Metadata
- Authors
- Bernert, J. T., Turner, W. E., Pirkle, J. L., Sosnoff, C. S., Akins, J. R., Waldrep, M. K., Ann, Q., Covey, T. R., Whitfield, W. E., Gunter, E. W., Miller, B. B., Patterson, D. G., Needham, L. L., Hannon, W. H., & Sampson, E. J.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-12-01
- Volume
- 43
- Issue
- 12
- Pages
- 2281-2291
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2154694813
- Cited by
- 337
- References
- 2
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Development and validation of sensitive method for determination of serum cotinine in smokers and nonsmokers by liquid chromatography/atmospheric pressure ionization tandem mass spectrometry. https://app.cochat.ai/papers/10.1093/clinchem/43.12.2281
- The paper
- Bernert, J. T., Turner, W. E., Pirkle, J. L., Sosnoff, C. S., Akins, J. R., Waldrep, M. K., Ann, Q., Covey, T. R., Whitfield, W. E., Gunter, E. W., Miller, B. B., Patterson, D. G., Needham, L. L., Hannon, W. H., & Sampson, E. J. (1997). Development and validation of sensitive method for determination of serum cotinine in smokers and nonsmokers by liquid chromatography/atmospheric pressure ionization tandem mass spectrometry. Clinical Chemistry. https://doi.org/10.1093/clinchem/43.12.2281
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
