The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Advanced multiplexed analysis with the FlowMetrixTM system
Abstract
The FlowMetrixTM System is a multiplexed data acquisition and analysis platform for flow cytometric analysis of microsphere-based assays that performs simultaneous measurement of up to 64 different analytes. The system consists of 64 distinct sets of fluorescent microspheres and a standard benchtop flow cytometer interfaced with a personal computer containing a digital signal processing board and Windows95®-based software. Individual sets of microspheres can be modified with reactive components such as antigens, antibodies, or oligonucleotides, and then mixed to form a multiplexed assay set. The digital signal-processing hardware and Windows95-based software provide complete control of the flow cytometer and perform real-time data processing, allowing multiple independent reactions to be analyzed simultaneously. The system has been used to perform qualitative and quantitative immunoassays for multiple serum proteins in both capture and competitive inhibition assay formats. The system has also been used to perform DNA sequence analysis by multiplexed competitive hybridization with 16 different sequence-specific oligonucleotide probes.
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Cites
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Allergy Diagnostic Testing: An Updated Practice Parameter
Bernstein, I. L., Li, J. T., Bernstein, D. I., Hamilton, R., Spector, S. L., Tan, R., Sicherer, S., Golden, D. B. K., Khan, D. A., Nicklas, R. A., et al. (2008) · Annals of Allergy, Asthma & Immunology · doi:10.1016/s1081-1206(10)60305-5 · Cited by 723
Zunder, E. R., Finck, R., Behbehani, G. K., Amir, E.-A. D., Krishnaswamy, S., Gonzalez, V. D., Lorang, C. G., Bjornson, Z., Spitzer, M. H., Bodenmiller, B., et al. (2015) · Nature Protocols · doi:10.1038/nprot.2015.020 · Cited by 596
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Multiplexed detection of pathogen DNA with DNA-based fluorescence nanobarcodes
Li, Y., Cu, Y. T. H., & Luo, D. (2005) · Nature Biotechnology · doi:10.1038/nbt1106 · Cited by 517
Ansotegui, I. J., Melioli, G., Canonica, G. W., Caraballo, L., Villa, E., Ebisawa, M., Passalacqua, G., Savi, E., Ebo, D., Gómez, R. M., et al. (2020) · World Allergy Organization Journal · doi:10.1016/j.waojou.2019.100080 · Cited by 489
Metadata
- Authors
- Fulton, R. J., McDade, R. L., Smith, P. L., Kienker, L. J., & Kettman, J. R.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-09-01
- Volume
- 43
- Issue
- 9
- Pages
- 1749-1756
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W4297632218
- Cited by
- 650
- References
- 10
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fulton, R. J., McDade, R. L., Smith, P. L., Kienker, L. J., & Kettman, J. R. (1997). Advanced multiplexed analysis with the FlowMetrixTM system. Clinical Chemistry. https://doi.org/10.1093/clinchem/43.9.1749
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
