The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Three different mutations in codon 61 of the human N-ras gene detected by synthetic oligonucleotide hybridization
Open accessAbstract
The activation of ras genes in naturally occurring tumors has, thus far, been found to be due to mutations in codon 12 or 61 resulting in single amino acid substitutions. We have used highly labeled synthetic oligonucleotides to detect mutations in these codons and to determine the exact position of the mutation. Using this approach we have found three different mutations in codon 61 of the N-ras gene of various human tumor cell lines. In the fibrosarcoma line HT1080 the first nucleotide of the codon is mutated; in the promyelocytic line HL60 the second and in the rhabdomyosarcoma line RD301 the third nucleotide. For RD301 this implies that the normal glutamine residue at position 61 is replaced by histidine. In addition to the mutated N-ras gene the three cell lines have a normal N-ras gene which is indicative of the dominant character of the mutations.
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Cites
Mechanism of activation of a human oncogene
Tabin, C. J., Bradley, S. M., Bargmann, C. I., Weinberg, R. A., Papageorge, A. G., Scolnick, E. M., Dhar, R., Lowy, D. R., & Chang, E. H. (1982) · Nature · doi:10.1038/300143a0 · Cited by 1,393
Santos, E., Martin-Zanca, D., Reddy, E. P., Pierotti, M. A., Della Porta, G., & Barbacid, M. (1984) · Science · doi:10.1126/science.6695174 · Cited by 418
Nakano, H., Yamamoto, F., Neville, C., Evans, D., Mizuno, T., & Perucho, M. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.1.71 · Cited by 133
Cited by
Orita, M., Suzuki, Y., Sekiya, T., & Hayashi, K. (1989) · Genomics · doi:10.1016/0888-7543(89)90129-8 · Cited by 3,434
Advanced multiplexed analysis with the FlowMetrixTM system
Fulton, R. J., McDade, R. L., Smith, P. L., Kienker, L. J., & Kettman, J. R. (1997) · Clinical Chemistry · doi:10.1093/clinchem/43.9.1749 · Cited by 650
Smit, M., de Knijff, P., van der Kooij-Meijs, E., Groenendijk, C., van den Maagdenberg, A., Gevers Leuven, J., Stalenhoef, A., Stuyt, P., Frants, R., & Havekes, L. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42759-2 · Cited by 74
Metadata
- Authors
- Bos, J. L., Vries, M. V.-D., Jansen, A. M., Veeneman, G. H., van Boom, J. H., & van der Eb, A. J.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1984
- Volume
- 12
- Issue
- 23
- Pages
- 9155-9163
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W1984969823
- Cited by
- 164
- References
- 3
- FWCI
- 6.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bos, J. L., Vries, M. V.-D., Jansen, A. M., Veeneman, G. H., van Boom, J. H., & van der Eb, A. J. (1984). Three different mutations in codon 61 of the human N-ras gene detected by synthetic oligonucleotide hybridization. Nucleic Acids Research. https://doi.org/10.1093/nar/12.23.9155
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