The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Role of nitric oxide in cardiovascular disease: focus on the endothelium
Open accessAbstract
Nitric oxide is a soluble gas continuously synthesized by the endothelium. This substance has a wide range of biological properties that maintain vascular homeostasis, including modulation of vascular dilator tone, regulation of local cell growth, and protection of the vessel from injurious consequences of platelets and cells circulating in blood. A growing list of conditions, including those commonly associated as risk factors for atherosclerosis such as hypertension and hypercholesterolemia, are associated with diminished release of nitric oxide into the arterial wall either because of impaired synthesis or excessive oxidative degradation. Diminished nitric oxide bioactivity may cause constriction of coronary arteries during exercise or during mental stress and contribute to provocation of myocardial ischemia in patients with coronary artery disease. Additionally, diminished nitric oxide bioactivity may facilitate vascular inflammation that could lead to oxidation of lipoproteins and foam cell formation, the precursor of the atherosclerotic plaque. Numerous therapies have been investigated to assess the possibility of reversing endothelial dysfunction by enhancing the release of nitric oxide from the endothelium, either through stimulation of nitric oxide synthesis or protection of nitric oxide from oxidative inactivation and conversion to toxic molecules such as peroxynitrite. Accordingly, causal relationships between improved endothelial function and reduction in myocardial ischemia and acute coronary events can now be investigated.
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Cites
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Cited by
Benavente-García, O., & Castillo, J. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8006568 · Cited by 1,158
Antioxidant defence mechanisms: From the beginning to the end (of the beginning)
Halliwell, B. (1999) · Free Radical Research · doi:10.1080/10715769900300841 · Cited by 1,020
Brozovich, F. V., Nicholson, C. J., Degen, C. V., Gao, Y. Z., Aggarwal, M., & Morgan, K. G. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.010652 · Cited by 542
The controversy over homocysteine and cardiovascular risk
Ueland, P. M., Refsum, H., Beresford, S. A., & Vollset, S. E. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.2.324 · Cited by 517
Innes, K. E., Bourguignon, C., & Taylor, A. G. (2005) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.18.6.491 · Cited by 425
Metadata
- Authors
- Cannon, R. O.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-08-01
- Volume
- 44
- Issue
- 8
- Pages
- 1809-1819
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2131100702
- Cited by
- 349
- References
- 85
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
