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Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders
Open accessAbstract
The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen. We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases regulate contractility of the vascular smooth muscle cell and we place this within the context of whole body function. We also discuss the implications for personalized medicine and highlight specific potential target molecules that may provide opportunities for the future development of new therapeutics to regulate vascular function.
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Cites
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Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
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Vascular smooth muscle contraction in hypertension
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Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity
Frismantiene, A., Philippova, M., Erne, P., & Resink, T. J. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.08.019 · Cited by 406
Yang, G., Li, X., He, Y., Ma, J., Ni, G., & Zhou, S. (2018) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2017.12.003 · Cited by 336
Li, Q., Cheng, Y., Zhang, Z., Bi, Z., Ma, X., Wei, Y., & Wei, X. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.1036 · Cited by 77
Metadata
- Authors
- Brozovich, F. V., Nicholson, C. J., Degen, C. V., Gao, Y. Z., Aggarwal, M., & Morgan, K. G.
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 68
- Issue
- 2
- Pages
- 476-532
- ISSN
- 0031-6997 (ISSN-L)
- OpenAlex
- W2325318720
- Cited by
- 542
- References
- 572
- FWCI
- 17.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Brozovich, F. V., Nicholson, C. J., Degen, C. V., Gao, Y. Z., Aggarwal, M., & Morgan, K. G. (2016). Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders. Pharmacological Reviews. https://doi.org/10.1124/pr.115.010652
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
