The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Ligand assays: from electrophoresis to miniaturized microarrays
Open accessAbstract
The main developments in the “ligand assay” field in which I have been involved are traced. These include the original development of “first generation” competitive assays relying on radiolabeled analyte markers; the development of the first “second generation”, noncompetitive (ultrasensitive) methods, which rely on the use of labeled (monoclonal) antibodies and high specific activity nonisotopic labels (leading to the transformation of the immunodiagnostic field in the 1980s); and the development of the first “third generation” miniaturized, chip-based, microarray methods, which permit the simultaneous ultrasensitive measurement of many analytes in the same small sample. The latter—applicable both to immunoassay and to DNA/RNA analysis—are likely to revolutionize the diagnostic and pharmaceutical fields in the next decade.
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Citations
Cites
Immunoassay of endogenous plasma insulin in man
Yalow, R. S., & Berson, S. A. (1960) · Journal of Clinical Investigation · doi:10.1172/jci104130 · Cited by 3,041
DIAGNOSIS OF ALLERGY BY AN IN-VITRO TEST FOR ALLERGEN ANTIBODIES
Wide, L., Bennich, H., & Johansson, S. G. O. (1967) · The Lancet · doi:10.1016/s0140-6736(67)90615-0 · Cited by 1,253
Cited by
Nanostructures in Biodiagnostics
Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
EAACI Molecular Allergology User's Guide
Matricardi, P. M., Kleine‐Tebbe, J., Hoffmann, H. J., Valenta, R., Hilger, C., Hofmaier, S., Aalberse, R. C., Agache, I., Asero, R., Ballmer‐Weber, B., et al. (2016) · Pediatric Allergy and Immunology · doi:10.1111/pai.12563 · Cited by 932
Protein Microarrays for Gene Expression and Antibody Screening
Lueking, A., Horn, M., Eickhoff, H., Büssow, K., Lehrach, H., & Walter, G. (1999) · Analytical Biochemistry · doi:10.1006/abio.1999.4063 · Cited by 433
EAACI Molecular Allergology User's Guide 2.0
Dramburg, S., Hilger, C., Santos, A. F., de las Vecillas, L., Aalberse, R. C., Acevedo, N., Aglas, L., Altmann, F., Arruda, K. L., Asero, R., et al. (2023) · Pediatric Allergy and Immunology · doi:10.1111/pai.13854 · Cited by 298
Richards, K., Rijntjes, E., Rathmann, D., & Köhrle, J. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.01.032 · Cited by 23
Metadata
- Authors
- Ekins, R. P.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-09-01
- Volume
- 44
- Issue
- 9
- Pages
- 2015-2030
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2111664616
- Cited by
- 299
- References
- 2
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ekins, R. P. (1998). Ligand assays: from electrophoresis to miniaturized microarrays. Clinical Chemistry. https://doi.org/10.1093/clinchem/44.9.2015
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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