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Quantitative Abnormalities of Fetal DNA in Maternal Serum in Preeclampsia
Abstract
Background: There is much recent interest in the biologic and diagnostic implication of cell-free non-host DNA in the plasma and serum of human subjects. To determine if quantitative abnormalities of circulating non-host DNA may be associated with certain pathologic processes, we used circulating fetal DNA in preeclampsia as a model system. Methods: We studied 20 preeclamptic women and 20 control subjects of comparable gestational age (means, 32 and 33 weeks, respectively). Male fetal DNA in maternal serum was measured using real-time quantitative PCR for the SRY gene on the Y chromosome. Results: The imprecision (CV) of the assay was 2.7%. The median circulating fetal DNA was increased fivefold in 20 preeclamptic women compared with 20 control pregnant women (381 vs 76 genome-equivalents/mL, P <0.001). Conclusions: These observations suggest that preeclampsia is associated with disturbances in the liberation and/or clearance mechanisms of circulating DNA. These results also raise the possibility that measurement of circulating DNA may prove useful as a marker for the diagnosis and/or monitoring of preeclampsia.
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Cited by
The preterm parturition syndrome
Romero, R., Espinoza, J., Kusanovic, J., Gotsch, F., Hassan, S., Erez, O., Chaiworapongsa, T., & Mazor, M. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.01120.x · Cited by 1,419
Szarka, A., Rigó, J., Lázár, L., Bekő, G., & Molvarec, A. (2010) · BMC Immunology · doi:10.1186/1471-2172-11-59 · Cited by 516
Placental Debris, Oxidative Stress and Pre-eclampsia
Redman, C. W. G., & Sargent, I. L. (2000) · Placenta · doi:10.1053/plac.2000.0560 · Cited by 508
Self-citationEffects of Blood-Processing Protocols on Fetal and Total DNA Quantification in Maternal Plasma
Chiu, R. W. K., Poon, L. L. M., Lau, T. K., Leung, T. N., Wong, E. M. C., & Lo, Y. M. D. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.9.1607 · Cited by 351
Self-citationTsang, J. C. H., Vong, J. S. L., Ji, L., Poon, L. C. Y., Jiang, P., Lui, K. O., Ni, Y.-B., To, K. F., Cheng, Y. K. Y., Chiu, R. W. K., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710470114 · Cited by 328
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Metadata
- Authors
- Lo, Y. D., Leung, T. N., Tein, M. S., Sargent, I. L., Zhang, J., Lau, T. K., Haines, C. J., & Redman, C. W.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-02-01
- Volume
- 45
- Issue
- 2
- Pages
- 184-188
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W1916944394
- Cited by
- 483
- References
- 0
- FWCI
- 21.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lo, Y. D., Leung, T. N., Tein, M. S., Sargent, I. L., Zhang, J., Lau, T. K., Haines, C. J., & Redman, C. W. (1999). Quantitative Abnormalities of Fetal DNA in Maternal Serum in Preeclampsia. Clinical Chemistry. https://doi.org/10.1093/clinchem/45.2.184
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