Immunoglobulin prophylaxis for hepatitis A.

Winokur, P. L.; Stapleton, J. T.

doi:10.1093/clinids/14.2.580

Cited by 137Hepatitis Viruses Studies and EpidemiologyHepatitis B Virus StudiesViral gastroenteritis research and epidemiology

The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.

Immunoglobulin prophylaxis for hepatitis A.

Winokur, P. L., Stapleton, J. T.·1992·Clinical Infectious Diseases

DOI 10.1093/clinids/14.2.580

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Abstract

Studies conducted over the past 45 years have shown that immunoglobulin (IG) prevents 80%-90% of cases of hepatitis A when administered before exposure or shortly thereafter. Protection is short lived and requires early diagnosis and timely administration of IG to contacts. Inactivated and attenuated hepatitis A virus (HAV) vaccines have recently been developed and should be available for clinical use within the next few years. Evaluation of antibodies to HAV in IG and in IG recipients provides one method of determining the immunogenicity of HAV vaccines. The role of IG in the prevention of hepatitis A is reviewed with emphasis on the relationship of antibody response following IG administration to the efficacy of HAV vaccines.

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When administered IM <2 weeks after exposure to HAV, IG is >85% effective in preventing HAV infection.
“When administered IM <2 weeks after exposure to HAV, IG is >85% effective in preventing HAV infection (1308).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1308]

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Authors: Winokur, P. L., & Stapleton, J. T.
Affiliations: University of Iowa (US)
Corresponding author: Stapleton, J. T.
ORCID: Winokur, P. L.
Stapleton, J. T.
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 1992-02-01
Volume: 14
Issue: 2
Pages: 580-586
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1093/clinids/14.2.580
OpenAlex: W2017352315
Cited by: 136
References: 73
Citations by year: 2025: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 3
FWCI: 5.47
Type: journal article
Language: en
Open access: closed
Locations: Clinical Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Hepatitis Viruses Studies and Epidemiology
Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
Keywords: hepatitis A, immunoglobulin prophylaxis, hepatitis A virus, inactivated vaccine, live attenuated vaccine, vaccine immunogenicity, antibody response, post-exposure prophylaxis
MeSH terms: Hepatitis A, Humans, Immunization, Passive

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Immunoglobulin prophylaxis for hepatitis A.

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