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Predictive Factors for Invasive Disease Due to Penicillin-Resistant Streptococcus pneumoniae: A Population-Based Study
Abstract
A prospective population-based study was carried out to determine predictive factors associated with penicillin-resistant pneumococcal invasive disease. A total of 374 patients (250 males and 124 females; mean age, 50.3 +/- 27 years) with invasive pneumococcal infection were admitted to one of the five hospitals in El Vallés County (an industrial area with 800,000 inhabitants in the province of Barcelona, Spain) over a period of 5 years. Of the 374 episodes, 21 (5.6%) were due to highly penicillin-resistant pneumococci and 67 (17.9%) to intermediately penicillin-resistant pneumococci. Multivariate analysis showed a statistically significant association between infection with intermediately penicillin-resistant pneumococci and an age of 0-4 years (odds ratio [OR] = 5.3; 95% confidence interval [CI] = 2.2-12.6), the presence of an immunosuppressive underlying disease (OR = 3.0; 95% CI = 1.5-6.0), and the previous use of beta-lactam antibiotics (OR = 2.1; 95% CI = 1.0-4.5). Infection with highly penicillin-resistant pneumococci was associated only with the previous use of beta-lactam antibiotics (OR = 5.9; 95% 95% CI = 2.2-15.8). Highly resistant strains were of serotypes 6, 9, 14, 15, 19, and 23, of which all but serotypes 9 and 15 are included in the newly formulated conjugated vaccine.
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Cited by
Clinical Practice Guideline (Update): Adult Sinusitis
Rosenfeld, R. M., Piccirillo, J. F., Chandrasekhar, S. S., Brook, I., Ashok Kumar, K., Kramper, M., Orlandi, R. R., Palmer, J. N., Patel, Z. M., Peters, A., et al. (2015) · Otolaryngology–Head and Neck Surgery · doi:10.1177/0194599815572097 · Cited by 1,159
Pallares, R., Liñares, J., Vadillo, M., Cabellos, C., Manresa, F., Viladrich, P. F., Martin, R., & Gudiol, F. (1995) · New England Journal of Medicine · doi:10.1056/nejm199508243330802 · Cited by 773
Doern, G. V., Brueggemann, A., Holley, H. P., & Rauch, A. M. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.5.1208 · Cited by 482
Yu, V. L., Chiou, C. C. C., Feldman, C., Ortqvist, A., Rello, J., Morris, A. J., Baddour, L. M., Luna, C. M., Snydman, D. R., Ip, M., et al. (2003) · Clinical Infectious Diseases · doi:10.1086/377534 · Cited by 451
Lefort, A., Mainardi, J.-L., Selton-Suty, C., Casassus, P., Guillevin, L., & Lortholary, O. (2000) · Medicine · doi:10.1097/00005792-200009000-00006 · Cited by 102
Metadata
- Authors
- Nava, J. M., Bella, F., Garau, J., Lite, J., Morera, M.-A., Marti, C., Fontanals, D., Font, B., Pineda, V., Uriz, S., Deulofeu, F., Calderon, A., Duran, P., Grau, M., & Agudo, A.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-11-01
- Volume
- 19
- Issue
- 5
- Pages
- 884-890
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2063041653
- Cited by
- 215
- References
- 0
- FWCI
- 12.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Predictive Factors for Invasive Disease Due to Penicillin-Resistant Streptococcus pneumoniae: A Population-Based Study. https://app.cochat.ai/papers/10.1093/clinids/19.5.884
- The paper
- Nava, J. M., Bella, F., Garau, J., Lite, J., Morera, M.-A., Marti, C., Fontanals, D., Font, B., Pineda, V., Uriz, S., Deulofeu, F., Calderon, A., Duran, P., Grau, M., & Agudo, A. (1994). Predictive Factors for Invasive Disease Due to Penicillin-Resistant Streptococcus pneumoniae: A Population-Based Study. Clinical Infectious Diseases. https://doi.org/10.1093/clinids/19.5.884
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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