The DOI matches its Crossref record; 11 of the 12 references it cites were found in a registry or an index.
Lactobacilli and Bacteremia in Southern Finland, 1989-1992
Abstract
In order to assess the potential of lactobacilli to cause serious infections, we studied the prevalence of bacteremia due to Lactobacillus species during a 4-year period (1989-1992) in southern Finland, which has a population of about 2.5 million. Among 3,317 blood culture isolates, lactobacilli were identified in eight patients, five of whom had a severe disease predisposing to bacteremic complications. The eight strains isolated were identified to the species level and typed by carbohydrate fermentation tests and by direct sequencing of enzymatically amplified 16S rRNA. The results did not provide evidence that any particular species or subspecies of Lactobacillus was the cause of the infections; no infections caused by isolates similar to the recently introduced dairy probiotic strain, Lactobacillus GG (ATCC 53103), were observed. The data show an infrequent association of lactobacilli with bacteremic infections in spite of the ubiquitous presence of these organisms in the gastrointestinal tract and their widespread consumption in fermented milks; thus, there is strong evidence that their pathogenic potential is very low.
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“The prevalence of LB is generally low, comprising 0.1–0.2% of all isolates identified in blood cultures from hospitalized patients and 0.5% of blood isolates from immunocompromised patients [2,10,18,19,20].”
From Lactobacillus Bacteremia and Probiotics: A Review (2023) · cites this paper as [19]
Citations
Cites
Rapid determination of 16S ribosomal RNA sequences for phylogenetic analyses.
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Isolauri, E., Juntunen, M., Rautanen, T., Sillanaukee, P., & Koivula, T. (1991) · PubMed · Cited by 684
Survival ofLactobacillus species (strain GG) in human gastrointestinal tract
Goldin, B. R., Gorbach, S. L., Saxelin, M., Barakat, S., Gualtieri, L. N., & Salminen, S. (1992) · Digestive Diseases and Sciences · doi:10.1007/bf01308354 · Cited by 554
Self-citationLactobacillus Feeding Reduces Endotoxemia and Severity of Experimental Alcoholic Liver (Disease)
Nanji, A. A., Khettry, U., & Sadrzadeh, S. M. H. (1994) · Experimental Biology and Medicine · doi:10.3181/00379727-205-43703 · Cited by 436
Lactic acid bacteria and human clinical infection
Aguirre, M., & Collins, M. D. (1993) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1993.tb02753.x · Cited by 425
Enteral feeding of premature infants with Lactobacillus GG.
Millar, M. R., Bacon, C., Smith, S. L., Walker, V., & Hall, M. A. (1993) · Archives of Disease in Childhood · doi:10.1136/adc.69.5_spec_no.483 · Cited by 242
Böttger, E. C. (1989) · FEMS Microbiology Letters · doi:10.1016/0378-1097(89)90386-8 · Cited by 210
(1994) · Bulletin de l Institut Pasteur · Cited by 194
Saxelin, M., Ahokas, M., & Salminen, S. (1993) · Microbial Ecology in Health and Disease · doi:10.3109/08910609309141315 · Cited by 51
Self-citationEffects of feeding lactobacillus GG on lethal irradiation in mice
Dong, M.-Y., Chang, T., & Gorbach, S. L. (1987) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/0732-8893(87)90063-0 · Cited by 35
Self-citationToxicity of lactic acid bacteria.
Donohue, D., Deighton, M. A., Ahokas, J. T., & Salminen, S. (1993) · Cited by 28
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Functional food science and gastrointestinal physiology and function
Salminen, S., Bouley, C., Boutron, M.-C., Cummings, J. H., Franck, A., Gibson, G. R., Isolauri, E., Moreau, M.-C., Roberfroid, M., & Rowland, I. (1998) · British Journal of Nutrition · doi:10.1079/bjn19980108 · Cited by 1,398
Self-citationDEPARTMENT OF HEALTH & HUMAN SERVICES
Schuchat, A. (2015) · Pharmacy Today · doi:10.1016/s1042-0991(15)32122-8 · Cited by 1,108
Demonstration of safety of probiotics—A review
Salminen, S. (1998) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(98)00128-7 · Cited by 884
Self-citationSafety assessment of probiotics for human use
Sanders, M. E., Akkermans, L. M. A., Haller, D., Hammerman, C., Heimbach, J. T., Hörmannsperger, G., & Huys, G. (2010) · Gut Microbes · doi:10.4161/gmic.1.3.12127 · Cited by 816
Probiotic use in clinical practice: what are the risks?
Boyle, R. J., Robins-Browne, R. M., & Tang, M. L. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1256 · Cited by 776
Metadata
- Authors
- Saxelin, M., Chuang, N.-H., Chassy, B., Rautelin, H., Makela, P. H., Salminen, S., & Gorbach, S. L.
- Affiliations
- University of Turku (FI)
- Tufts University (US)
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-03-01
- Volume
- 22
- Issue
- 3
- Pages
- 564-566
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2068824740
- Cited by
- 186
- References
- 12
- Citations by year
- 2025: 1 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 6 · 2012: 6
- FWCI
- 23.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Microbiology (medical) › Infections and bacterial resistance
- Keywords
- Lactobacillus, bacteremia, blood culture isolates, 16S rRNA gene sequencing, Lactobacillus rhamnosus GG, fermented milk, probiotics, gastrointestinal tract colonization, southern Finland
- MeSH terms
- Adult, Aged, Female, Finland, Humans, Lactobacillus, Male, Middle Aged, RNA, Ribosomal, 16S, Bacteremia
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