Poliomyelitis Control in Japan
Abstract
The Sabin oral poliovirus vaccine ( OPV ) has been used in Japan since 1961. Since then the number of paralytic cases has decreased markedly. The incidence of paralytic and positive rates for antibodies to poliovirus were analyzed. The number of paralytic cases associated with OPV was low for cases due to type 1 virus and high for those due to type 2 virus. As for cases due to type 3 virus, the number was high until 1969 and has been low since 1970. This difference was brought about by changing the batch of type 3 virus used in the preparation of OPV . The analysis of titers of neutralizing antibody showed that response to type 1 virus in OPV used in 1977 and to type 3 virus in OPV used in 1972 and 1973 was not adequate. Both situations were improved by changing the batches of virus used for OPV . These experiences suggest that the use of good batches is necessary for safety and efficacy of OPV .
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Detailed analysis of the attenuated phenotype of Sabin 3 has been possible because the neurovirulent parental strain, Leon, differs from Sabin 3 by only 10 nucleotide substitutions.
“Detailed analysis of the attenuated phenotype of Sabin 3 has been possible because the neurovirulent parental strain, Leon, differs from Sabin 3 by only 10 nucleotide substitutions (182).”
From VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005) · cites this paper as [182]
Cites
Takatsu, T., TAGAYA, I., & Hirayama, M. (1973) · PubMed · Cited by 20 · see citing works
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VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION
Kew, O. M., Sutter, R. W., de Gourville, E. M., Dowdle, W. R., & Pallansch, M. A. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.58.030603.123625 · Cited by 703 · see citing works
Sabin, A. B. (1985) · Journal of Infectious Diseases · doi:10.1093/infdis/151.3.420 · Cited by 281 · see citing works
- Authors
- Shimojo, H.
- Corresponding author
- Shimojo, Hiroto
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1984-05-01
- Volume
- 6
- Issue
- Supplement_2
- Pages
- S427-S430
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2319116076
- Cited by
- 14
- References
- 1
- Citations by year
- 2014: 1 · 2013: 1
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Keywords
- poliomyelitis, poliovirus serotypes, neutralizing antibody titer, vaccine safety, vaccine efficacy, Japan
- MeSH terms
- Antibodies, Viral, Child, Preschool, Humans, Infant, Japan, Poliomyelitis, Poliovirus Vaccine, Oral, Vaccination
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