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Developmental changes in energy substrate use by the heart
Abstract
Marked changes in intermediary metabolism occur during development of the heart. In the fetus, the heart utilises lactate and glucose as its main energy substrates, while in the adult, fatty acids are the main energy substrate. The transition from carbohydrate to fatty acid metabolism is a complex process which involves maturation of mitochondrial processes and dramatic changes in circulating levels of fatty acids and lactate. In addition, developmental changes in the use of energy substrates also involve changes in the regulation of the enzymes involved in both carbohydrate and fatty acid utilisation. This paper reviews these changes in intermediary metabolism which occur during myocardial development. The metabolic differences that exist between immature and adult hearts may explain the observed differences in the ability of immature hearts to withstand hypoxaemia or ischaemia.
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Citations
Cited by
Lopaschuk, G. D., & Jaswal, J. S. (2010) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181e74a14 · Cited by 636
Self-citationMetabolic Gene Expression in Fetal and Failing Human Heart
Razeghi, P., Young, M. E., Alcorn, J. L., Moravec, C. S., Frazier, O. H., & Taegtmeyer, H. (2001) · Circulation · doi:10.1161/hc4901.100526 · Cited by 616
PGC-1 Coactivators in Cardiac Development and Disease
Rowe, G. C., Jiang, A., & Arany, Z. (2010) · Circulation Research · doi:10.1161/circresaha.110.223818 · Cited by 355
Adiponectin is synthesized and secreted by human and murine cardiomyocytes
Piñeiro, R., Iglesias, M. J., Gallego, R., Raghay, K., Eiras, S., Rubio, J., Diéguez, C., Gualillo, O., González-Juanatey, J. R., & Lago, F. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.07.098 · Cited by 350
Ahuja, P., Zhao, P., Angelis, E., Ruan, H., Korge, P., Olson, A., Wang, Y., Jin, E. S., Jeffrey, F. M., Portman, M., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci38331 · Cited by 157
Metadata
- Authors
- Lopaschuk, G. D., Collins-Nakai, R. L., & Itoi, T.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1992-12-01
- Volume
- 26
- Issue
- 12
- Pages
- 1172-1180
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W1989507960
- Cited by
- 316
- References
- 0
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Developmental changes in energy substrate use by the heart. https://app.cochat.ai/papers/10.1093/cvr/26.12.1172
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- Lopaschuk, G. D., Collins-Nakai, R. L., & Itoi, T. (1992). Developmental changes in energy substrate use by the heart. Cardiovascular Research. https://doi.org/10.1093/cvr/26.12.1172
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
