Exercise promotes angiogenesis and improves β-adrenergic receptor signalling in the post-ischaemic failing rat heart
Open accessAbstract
AIMS: We investigated whether exercise training could promote angiogenesis and improve blood perfusion and left ventricular (LV) remodelling of the post-myocardial infarction (MI) failing heart. We also explored the contribution of ameliorated beta-adrenergic receptor signalling and function on the overall improvement of cardiac contractility reserve induced by exercise. METHODS AND RESULTS: Adult Wistar male rats were randomly assigned to one of four experimental groups. Sham-operated and post-MI heart failure (HF) rats were housed under sedentary conditions or assigned to 10-weeks of a treadmill exercise protocol. At 4 weeks after MI, sedentary HF rats showed LV eccentric hypertrophy, marked increase of LV diameters associated with severely impaired fractional shortening (14 +/- 5%), increased LV end diastolic pressure (20.9 +/- 2.6 mmHg), and pulmonary congestion. In addition, cardiac contractile responses to adrenergic stimulation were significantly blunted. In trained HF rats, exercise was able to (i) reactivate the cardiac vascular endothelial growth factor pathway with a concurrent enhancement of myocardial angiogenesis, (ii) significantly increase myocardial perfusion and coronary reserve, (iii) reduce cardiac diameters, and (iv) improve LV contractility in response to adrenergic stimulation. This latter finding was also associated with a significant improvement of cardiac beta-adrenergic receptor downregulation and desensitization. CONCLUSIONS: Our data indicate that exercise favourably affects angiogenesis and improves LV remodelling and contractility reserve in a rat model of severe chronic HF.
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Exercise intervention after MI can enhance myocardial angiogenesis and perfusion in post-ischaemic failing rat hearts.
“exercise intervention after MI can enhance myocardial angiogenesis and perfusion, reduce cardiac diameters, and improve LV contractility in post-ischaemic failing rat hearts 160”
From Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation (2023) · cites this paper as [160]
Exercise intervention after MI can improve LV contractility in post-ischaemic failing rat hearts.
“exercise intervention after MI can enhance myocardial angiogenesis and perfusion, reduce cardiac diameters, and improve LV contractility in post-ischaemic failing rat hearts 160”
From Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation (2023) · cites this paper as [160]
Exercise intervention after MI can reduce cardiac diameters in post-ischaemic failing rat hearts.
“exercise intervention after MI can enhance myocardial angiogenesis and perfusion, reduce cardiac diameters, and improve LV contractility in post-ischaemic failing rat hearts 160”
From Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation (2023) · cites this paper as [160]
Exercise-mediated improvement in myocardial regenerative capacity after MI is mediated by myocardial contractility through ameliorated beta-adrenergic receptor signalling and function.
“myocardial contractility (through an ameliorated beta-adrenergic receptor signalling and function); 160”
From Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation (2023) · cites this paper as [160]
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- Authors
- Leosco, D., Rengo, G., Iaccarino, G., Golino, L., Marchese, M., Fortunato, F., Zincarelli, C., Sanzari, E., Ciccarelli, M., Galasso, G., Altobelli, G. G., Conti, V., Matrone, G., Cimini, V., Ferrara, N., Filippelli, A., Koch, W. J., & Rengo, F.
- Affiliations
- University of Naples Federico II (IT)
- Thomas Jefferson University (US)
- University of Campania "Luigi Vanvitelli" (IT)
- Fondazione Salvatore Maugeri (IT)
- ORCID
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-12-18
- Volume
- 78
- Issue
- 2
- Pages
- 385-394
- ISSN
- 0008-6363 (ISSN-L)
- 1755-3245
- OpenAlex
- W2122251453
- Cited by
- 131
- References
- 41
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 10 · 2015: 13 · 2014: 7 · 2013: 16 · 2012: 15
- FWCI
- 15.03
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Keywords
- exercise training, myocardial angiogenesis, heart failure, myocardial infarction, left ventricular remodeling, endothelial growth factor, myocardial perfusion, coronary reserve, cardiac contractility, receptor desensitization, eccentric hypertrophy
- MeSH terms
- Adrenergic beta-Agonists, Animals, Coronary Circulation, Coronary Vessels, Disease Models, Animal, Dose-Response Relationship, Drug, Physical Exertion, Heart Failure, Isoproterenol, Male, Myocardial Contraction, Myocardial Infarction, Myocardium, Receptors, Adrenergic, beta, Time Factors, Ultrasonography, Signal Transduction, Ventricular Function, Left, Rats, Wistar, Neovascularization, Physiologic, Ventricular Remodeling, Vascular Endothelial Growth Factor A, Proto-Oncogene Proteins c-akt, Rats, Nitric Oxide Synthase Type II, Nitric Oxide Synthase Type III
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