Effect of exercise-based cardiac rehabilitation on left ventricular function in Asian patients with acute myocardial infarction after percutaneous coronary intervention: a meta-analysis of randomized controlled trials
Open accessAbstract
(1) Background: The effects of exercise-based cardiac rehabilitation (CR) on left ventricular function in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI) are important but poorly understood. (2) Purpose: To evaluate the effects of an exercise-based CR program (exercise training alone or combined with psychosocial or educational interventions) compared with usual care on left ventricular function in patients with AMI receiving PCI. (3) Data sources, study selection and data extraction: We searched PubMed, WEB OF SCIENCE, EMBASE, EBSCO, PsycINFO, LILACS and Cochrane Central Register of Controlled Trials databases (CENTRAL) up to 12th June 2021. Article selected were randomized controlled trials and published as a full-text article. Meta-analysis was conducted with the use of the software Review manager 5.4. (4) Data synthesis: Eight trials were included in the meta-analysis, of which three trials were rated as high risk of bias. A significant improvement was seen in the exercise-based CR group compared with the control group regarding left ventricular ejection fraction (LVEF) (std. mean difference = 1.33; 95% CI:0.43 to 2.23; p = 0.004), left ventricular end-diastolic dimension (LVEDD) (std. mean difference = −3.05; 95% CI: −6.00 to −0.09; p = 0.04) and left ventricular end-systolic volume (LVESV) (std. mean difference = −0.40; 95% CI: −0.80 to −0.01; p = 0.04). Although exercise-based CR had no statistical effect in decreasing left ventricular end-systolic dimension (LVESD) and left ventricular end-diastolic volume (LVEDV), it showed a favorable trend in relation to both. (5) Conclusions: Exercise-based CR has beneficial effects on LV function and remodeling in AMI patients treated by PCI.
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Meta-analytical evidence supports a decrease with exercise-based rehabilitation of LVESV in patients with MI subjected to percutaneous coronary intervention.
“More recently, meta-analytical evidence 163 also supports a decrease with exercise-based rehabilitation not only of LVESV but also of LV end-diastolic diameter, together with an increase in LVEF, in patients with MI subjected to percutaneous coronary intervention.”
From Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation (2023) · cites this paper as [163]
Meta-analytical evidence supports a decrease with exercise-based rehabilitation of LV end-diastolic diameter in patients with MI subjected to percutaneous coronary intervention.
“More recently, meta-analytical evidence 163 also supports a decrease with exercise-based rehabilitation not only of LVESV but also of LV end-diastolic diameter, together with an increase in LVEF, in patients with MI subjected to percutaneous coronary intervention.”
From Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation (2023) · cites this paper as [163]
Meta-analytical evidence supports an increase with exercise-based rehabilitation in LVEF in patients with MI subjected to percutaneous coronary intervention.
“More recently, meta-analytical evidence 163 also supports a decrease with exercise-based rehabilitation not only of LVESV but also of LV end-diastolic diameter, together with an increase in LVEF, in patients with MI subjected to percutaneous coronary intervention.”
From Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation (2023) · cites this paper as [163]
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Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation
Valenzuela, P. L., Ruilope, L. M., Santos-Lozano, A., Wilhelm, M., Kränkel, N., Fiuza-Luces, C., & Lucia, A. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad170 · Cited by 237 · see citing works
- Authors
- Wang, Y., Chien, C.-W., Xu, Y., & Tung, T.-H.
- Affiliations
- Tsinghua University (CN)
- Wenzhou Medical University (CN)
- Corresponding author
- Tung, Tao-Hsin
- Venue
- Healthcare
- Publisher
- MDPI AG
- Published
- 2021-06-21
- Volume
- 9
- Issue
- 6
- Pages
- 774
- ISSN
- 2227-9032 (ISSN-L)
- PMC
- PMC8234138
- OpenAlex
- W3176945762
- Cited by
- 15
- References
- 47
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 2
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Healthcare (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- exercise-based cardiac rehabilitation, left ventricular function, acute myocardial infarction, percutaneous coronary intervention, left ventricular ejection fraction, left ventricular remodeling, left ventricular end-diastolic diameter, left ventricular end-systolic volume, psychosocial interventions, educational intervention, Asian patients
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