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Dipeptidyl peptidase IV (DPP IV) inhibitors: a newly emerging drug class for the treatment of type 2 diabetes

Green, B. D., Flatt, P. R., & Bailey, C. J. (2006) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2006.024 · Cited by 225 · see citing works

Mitochondrial Dysfunction and Lipid Accumulation in the Human Diaphragm during Mechanical Ventilation

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High glucose condition increases NADPH oxidase activity in endothelial microparticles that promote vascular inflammation

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PGC-1α Regulates Expression of Myocardial Mitochondrial Antioxidants and Myocardial Oxidative Stress After Chronic Systolic Overload

Lu, Z., Xu, X., Hu, X., Fassett, J., Zhu, G., Tao, Y., Li, J., Huang, Y., Zhang, P., Zhao, B., et al. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2940 · Cited by 215 · see citing works

Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening

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Endothelial Dysfunction and Diabetic Cardiomyopathy

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Therapeutic host-directed strategies to improve outcome in tuberculosis

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Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway

Hou, X., Song, J., Li, X., Zhang, L., Wang, X., Chen, L., & Shen, Y. H. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.04.017 · Cited by 202 · see citing works

Multi-regulatory network of ROS: the interconnection of ROS, PGC-1 alpha, and AMPK-SIRT1 during exercise.

Thirupathi, A., & de Souza, C. T. (2017) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-017-0576-y · Cited by 198 · see citing works

Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases

Whitaker, R. M., Corum, D. G., Beeson, C., & Schnellmann, R. G. (2015) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103155 · Cited by 200 · see citing works

Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats

Ungvari, Z. I., Labinskyy, N., Gupte, S. A., Chander, P. N., Edwards, J. G., & Csiszár, A. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00012.2008 · Cited by 202 · see citing works

Nutritional Ketosis and Mitohormesis: Potential Implications for Mitochondrial Function and Human Health

Miller, V. J., Villamena, F. A., & Volek, J. S. (2018) · Journal of Nutrition and Metabolism · doi:10.1155/2018/5157645 · Cited by 200 · see citing works

Effects of Long-Term Treatment with Quercetin on Cognition and Mitochondrial Function in a Mouse Model of Alzheimer’s Disease

Wang, D., Li, S., Wu, W., Zhu, X., Wang, Y., & Yuan, H. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1343-x · Cited by 196 · see citing works

Resveratrol Protects Mitochondria against Oxidative Stress through AMP-Activated Protein Kinase-Mediated Glycogen Synthase Kinase-3β Inhibition Downstream of Poly(ADP-ribose)polymerase-LKB1 Pathway

Shin, S. M., Cho, I. J., & Kim, S. G. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.058479 · Cited by 195 · see citing works

The Pathogenesis of Diabetes Mellitus by Oxidative Stress and Inflammation: Its Inhibition by Berberine

Ma, X., Chen, Z., Wang, L., Wang, G., Wang, Z., Dong, X., Wen, B., & Zhang, Z. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00782 · Cited by 189 · see citing works

Downregulation of AMPK Accompanies Leucine- and Glucose-Induced Increases in Protein Synthesis and Insulin Resistance in Rat Skeletal Muscle

Saha, A. K., Xu, X. J., Lawson, E., Deoliveira, R., Brandon, A. E., Kraegen, E. W., & Ruderman, N. B. (2010) · Diabetes · doi:10.2337/db09-1870 · Cited by 188 · see citing works

AMP-Activated Protein Kinase

Salt, I. P., & Hardie, D. G. (2017) · Circulation Research · doi:10.1161/circresaha.117.309633 · Cited by 186 · see citing works

The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity

Timm, K. N., & Tyler, D. J. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-06941-x · Cited by 189 · see citing works

2-Deoxy-D-Glucose Treatment of Endothelial Cells Induces Autophagy by Reactive Oxygen Species-Mediated Activation of the AMP-Activated Protein Kinase

Wang, Q., Liang, B., Shirwany, N. A., & Zou, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017234 · Cited by 181 · see citing works

High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate–activated protein kinase

Adachi, M., & Brenner, D. A. (2008) · Hepatology · doi:10.1002/hep.21991 · Cited by 182 · see citing works

Mitochondrial Pathways, Permeability Transition Pore, and Redox Signaling in Cardioprotection: Therapeutic Implications

Penna, C. R. R., Perrelli, M.-G., & Pagliaro, P. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4459 · Cited by 182 · see citing works

AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model

Giri, S., Rattan, R., Haq, E., Khan, M., Yasmin, R., Won, J., Key, L., Singh, A. K., & Singh, I. (2006) · Nutrition & Metabolism · doi:10.1186/1743-7075-3-31 · Cited by 180 · see citing works

AMPK, metabolism, and vascular function

Rodríguez, C., Muñoz, M., Contreras, C., & Prieto, D. (2021) · FEBS Journal · doi:10.1111/febs.15863 · Cited by 178 · see citing works

Bile???Acid???Sequestrants???and???the???Treatment of Type??2??Diabetes??Mellitus

Staels, B., & Kuipers, F. (2007) · Drugs · doi:10.2165/00003495-200767100-00001 · Cited by 174 · see citing works

Peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC1α) is a metabolic regulator of intestinal epithelial cell fate

D’Errico, I., Salvatore, L., Murzilli, S., Sasso, G. L., Latorre, D., Martelli, N., Egorova, A. V., Polishuck, R. S., Madeyski-Bengtson, K., Lelliott, C. J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016354108 · Cited by 175 · see citing works

AMP ‐activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1

Yun, H., Park, S., Kim, M., Yang, W. K., Im, D. U., Yang, K. R., Hong, J., Choe, W., Kang, I., Kim, S. S., et al. (2014) · FEBS Journal · doi:10.1111/febs.12949 · Cited by 171 · see citing works

Advances in pathogenesis and treatment of vascular endothelial injury-related diseases mediated by mitochondrial abnormality

Pang, B., Dong, G., Pang, T., Sun, X., Liu, X., Nie, Y., & Chang, X. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1422686 · Cited by 174 · see citing works

Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival

Liu, X., Peyton, K. J., Shebib, A. R., Wang, H., Korthuis, R. J., & Durante, W. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00749.2010 · Cited by 171 · see citing works

The role of PGC-1α on mitochondrial function and apoptotic susceptibility in muscle

Adhihetty, P. J., Uguccioni, G., Leick, L., Hidalgo, J., Pilegaard, H., & Hood, D. A. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00070.2009 · Cited by 168 · see citing works

Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase

Wang, Y., Huang, Y., Lam, K. S. L., Li, Y., Wong, W. T., Ye, H., Lau, C., Vanhoutte, P. M., & Xu, A. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp078 · Cited by 165 · see citing works

Metabolic Pathways Fueling the Endothelial Cell Drive

Li, X., Kumar, A., & Carmeliet, P. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114731 · Cited by 165 · see citing works

Insights for Oxidative Stress and mTOR Signaling in Myocardial Ischemia/Reperfusion Injury under Diabetes

Zhao, D., Yang, J. Z., & Yang, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/6437467 · Cited by 162 · see citing works

Role of AMPK-mediated adaptive responses in human cells with mitochondrial dysfunction to oxidative stress

Wu, S., Wu, Y., Wu, T.-P., & Wei, Y. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.10.034 · Cited by 159 · see citing works

The transcriptional coactivator PGC-1α is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis

Lehman, J. J., Boudina, S., Banke, N. H., Sambandam, N., Han, X., Young, D. M., Leone, T. C., Gross, R. W., Lewandowski, E. D., Abel, E. D., et al. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00081.2008 · Cited by 158 · see citing works

Mitochondrial Dynamics and Mitochondrial Dysfunction in Diabetes.

Wada, J., & Nakatsuka, A. (2016) · PubMed · doi:10.18926/amo/54413 · Cited by 157 · see citing works

Diabetes regulates mitochondrial biogenesis and fission in mouse neurons

Edwards, J. L., Quattrini, A., Lentz, S. I., Figueroa-Romero, C., Cerri, F., Backus, C., Hong, Y., & Feldman, E. L. (2010) · Diabetologia · doi:10.1007/s00125-009-1553-y · Cited by 156 · see citing works

C-Peptide Activates AMPKα and Prevents ROS-Mediated Mitochondrial Fission and Endothelial Apoptosis in Diabetes

Bhatt, M. P., Lim, Y., Kim, Y., & Ha, K. (2013) · Diabetes · doi:10.2337/db13-0039 · Cited by 155 · see citing works

PGC-1alpha Down-Regulation Affects the Antioxidant Response in Friedreich's Ataxia

Marmolino, D., Manto, M. U., Acquaviva, F., Vergara, P., Ravella, A., Monticelli, A., & Pandolfo, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010025 · Cited by 145 · see citing works

AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genes

Matzinger, M., Fischhuber, K., Pölöske, D., Mechtler, K., & Heiß, E. H. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101393 · Cited by 145 · see citing works

Activation of AMP-Activated Protein Kinase Is Required for Berberine-Induced Reduction of Atherosclerosis in Mice: The Role of Uncoupling Protein 2

Wang, Q., Zhang, M., Liang, B., Shirwany, N. A., Zhu, Y., & Zou, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025436 · Cited by 144 · see citing works

Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation

Xu, Z., Feng, W., Shen, Q., Yu, N., Yu, K., Wang, S., Chen, Z., Shioda, S., & Guo, Y. (2017) · Aging and Disease · doi:10.14336/ad.2016.0620 · Cited by 143 · see citing works

AMPK: A cellular metabolic and redox sensor. A minireview

Shirwany, N. A. (2014) · Frontiers in bioscience · doi:10.2741/4218 · Cited by 142 · see citing works

Oxidative stress: A cause and therapeutic target of diabetic complications

Araki, E., & Nishikawa, T. (2010) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2010.00013.x · Cited by 139 · see citing works

Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation

Salt, I. P., & Palmer, T. M. (2012) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2012.696609 · Cited by 138 · see citing works

Effects of PGC-1α on TNF-α–Induced MCP-1 and VCAM-1 Expression and NF-κB Activation in Human Aortic Smooth Muscle and Endothelial Cells

Kim, H., Park, K., Yoo, E.-K., Kim, Y.-H., Kim, Y.-N., Kim, H., Kim, H. T., Park, J., Lee, K.-U., Jang, W. G., et al. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.1456 · Cited by 136 · see citing works

Dietary wolfberry ameliorates retinal structure abnormalities in db/db mice at the early stage of diabetes

Tang, L., Zhang, Y., Jiang, Y., Willard, L., Ortiz, E., Wark, L., Medeiros, D. M., & Lin, D. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.010400 · Cited by 135 · see citing works

AMP-activated protein kinase: A remarkable contributor to preserve a healthy heart against ROS injury

Marino, A., Hausenloy, D. J., Andreadou, I., Horman, S., Bertrand, L., & Beauloye, C. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.02.047 · Cited by 134 · see citing works

Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in HUVECs

久木留, 大., クキドメ, ダ., & Kukidome, D. (2006) · Kumamoto University Repository (Kumamoto University)

Metformin protects diabetes-induced atrial mitochondrial from oxidative stress and improves mitochondrial biogenesis via the AMPK signaling pathwayPreprint

Song, Y., Yuan, M., Zhang, Z., Zhang, Y., Yuan, M., Wang, H., Liang, X., Tse, G., Li, G., Liu, T., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3052103/v1

Generation of Reactive Oxygen Species by Endothelial and Smooth Muscle Cells: Influence of Hyperglycemia and Metformin

Bellin, C., de Wiza, D., Wiernsperger, N. F., & Rosen, P. (2006) · Hormone and Metabolic Research · doi:10.1055/s-2006-955084 · Cited by 88 · see citing works

Metformin protects high glucose‑cultured cardiomyocytes from oxidative stress by promoting NDUFA13 expression and mitochondrial biogenesis via the AMPK signaling pathway

Liu, X., Li, Y., Wang, G., Bi, Y., Zhao, Y. F., Yan, M., Liu, X., Meng, W., Wan, L., & Zhang, Q. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11599 · Cited by 39 · see citing works

Mitochondrial Function and Superoxide Production is Reduced in the Diabetic Kidney and Restored by AMPK Activation

You, Y. H., Dugan, L. L., Naviaux, R. K., & Sharma, K. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.687.7