The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Interleukin 8 and cardiovascular disease
Abstract
Since the establishment of the inflammatory basis of atherosclerosis, several pro- or anti-inflammatory agents have been examined as potential mediators of the biochemical pathways of lesion formation. Interleukin (IL)-8 was first characterized in 1987. Since then, knowledge regarding its role in leucocyte trafficking and activation has advanced rapidly, especially in the field of cardiovascular disease. In the scientific literature, there is sufficient evidence to support beyond any doubt the involvement of IL-8 in the establishment and preservation of the inflammatory micro-environment of the insulted vascular wall. However, how the information derived from in vitro studies and animal models can be applied in clinical practice has yet to be determined. In the present review, the available evidence regarding the role of IL-8 in cardiovascular disease is presented, and future perspectives are discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Chemokines — Chemotactic Cytokines That Mediate Inflammation
Luster, A. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380706 · Cited by 3,630
The Interleukin-8 Pathway in Cancer
Waugh, D. J. J., & Wilson, C. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4843 · Cited by 2,103
A new class of membrane-bound chemokine with a CX3C motif
Bazan, J. F., Bacon, K. B., Hardiman, G., Wang, W., Soo, K., Rossi, D., Greaves, D. R., Zlotnik, A., & Schall, T. J. (1997) · Nature · doi:10.1038/385640a0 · Cited by 2,013
Ross, R., & Glomset, J. A. (1973) · Science · doi:10.1126/science.180.4093.1332 · Cited by 1,501
Imai, T., Hieshima, K., Haskell, C., Baba, M., Nagira, M., Nishimura, M., Kakizaki, M., Takagi, S., Nomiyama, H., Schall, T. J., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80438-9 · Cited by 1,445
MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions
Gerszten, R. E., Garcia-Zepeda, E. A., Lim, Y.-C., Yoshida, M., Ding, H. A., Gimbrone, M. A., Luster, A. D., Luscinskas, F. W., & Rosenzweig, A. (1999) · Nature · doi:10.1038/19546 · Cited by 1,244
Cushing, S. D., Berliner, J. A., Valente, A. J., Territo, M. C., Navab, M., Parhami, F., Gerrity, R., Schwartz, C. J., & Fogelman, A. M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.13.5134 · Cited by 1,146
Quinn, M. T., Parthasarathy, S., Fong, L. G., & Steinberg, D. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.9.2995 · Cited by 1,137
Structure and Functional Expression of a Human Interleukin-8 Receptor
Holmes, W. E., Lee, J., Kuang, W.-J., Rice, G. C., & Wood, W. I. (1991) · Science · doi:10.1126/science.1840701 · Cited by 1,090
Cloning of Complementary DNA Encoding a Functional Human Interleukin-8 Receptor
Murphy, P. M., & Tiffany, H. L. (1991) · Science · doi:10.1126/science.1891716 · Cited by 871
Cited by
Quagliariello, V., De Laurentiis, M., Rea, D., Barbieri, A., Monti, M. G., Carbone, A., Paccone, A., Altucci, L., Conte, M., Canale, M. L., et al. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01346-y · Cited by 367
Randomized controlled trial for time-restricted eating in healthy volunteers without obesity
Xie, Z., Sun, Y., Ye, Y., Hu, D., Zhang, H., He, Z., Zhao, H., Yang, H., & Mao, Y. (2022) · Nature Communications · doi:10.1038/s41467-022-28662-5 · Cited by 276
Maes, M., Ruckoanich, P., Chang, Y. S., Mahanonda, N., & Berk, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.008 · Cited by 169
Aho, V., Ollila, H. M., Rantanen, V., Kronholm, E., Surakka, I., van Leeuwen, W. M. A., Lehto, M., Matikainen, S., Ripatti, S., Härmä, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077184 · Cited by 93
Co-Stimulation of PAFR and CD36 Is Required for oxLDL-Induced Human Macrophages Activation
Rios, F. J. O., Koga, M. M., Ferracini, M., & Jancar, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036632 · Cited by 51
Metadata
- Authors
- Apostolakis, S., Vogiatzi, K., Amanatidou, V., & Spandidos, D. A.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-07-18
- Volume
- 84
- Issue
- 3
- Pages
- 353-360
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2131918803
- Cited by
- 285
- References
- 58
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Interleukin 8 and cardiovascular disease. https://app.cochat.ai/papers/10.1093/cvr/cvp241
- The paper
- Apostolakis, S., Vogiatzi, K., Amanatidou, V., & Spandidos, D. A. (2009). Interleukin 8 and cardiovascular disease. Cardiovascular Research. https://doi.org/10.1093/cvr/cvp241
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
