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Cited by 209Cellular Mechanics and InteractionsLymphatic System and DiseasesBarrier Structure and Function Studies

Transcapillary exchange: Role and importance of the interstitial fluid pressure and the extracellular matrix

Reed, Rolf K., Rubin, Kristofer·2010·Cardiovascular Research
DOI 10.1093/cvr/cvq143
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Abstract

This review will summarize current knowledge on the role of the extracellular matrix (ECM) in general and on the interstitial fluid pressure (P(if)) in particular with regard to their importance in transcapillary exchange. The fluid volume in the interstitial space is normally regulated within narrow limits by automatic re-adjustment of the interstitial hydrostatic and colloid osmotic pressures in response to perturbations in capillary filtration and by the lymphatics. Contrary to this commonly accepted view, P(if) can become an active force and create a fluid flux across the capillaries in several inflammatory reactions and trauma situations rather than limit the changes occurring. The molecular mechanisms involved in the lowering of P(if) include the release of cellular tension exerted on the collagen and microfibril networks in the connective tissue via the collagen-binding beta(1)-integrins, thereby allowing the glycosaminoglycan ground substance, which is normally underhydrated, to expand and take up fluid. Several growth factors and cytokines, including the platelet-derived growth factor BB, are able to reverse a lowering of P(if) and restore the normal compaction of the ECM. The magnitude of the lowering of P(if) varies with the inflammatory response. In several inflammatory reactions, a lowering of P(if) to -5 to -10 mmHg is seen, which will increase capillary filtration by 10-20 times since the normal capillary filtration pressure is usually 0.5-1 mmHg (skin and skeletal muscle). Unless this lowering of P(if) is taken into account, the enhanced solute flux resulting from an inflammatory response will be ascribed to an increased capillary permeability.

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  • Elevated IFP diminishes convective transport, reduces vascular perfusion, and severely impairs drug accumulation in the tumor core.

    “This elevated IFP diminishes convective transport, reduces vascular perfusion, and severely impairs drug accumulation in the tumor core [88,89].”

    From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [88]

    The Introduction and the fluid-flux equation in §4 explain that interstitial fluid pressure affects transcapillary fluid and solute flux; §5 identifies convection as a component of solute transport. This supports the general transport mechanism, but the paper does not establish that elevated pressure reduces vascular perfusion or severely impairs drug accumulation in a tumor core (no page numbers supplied). (LLM, conf=0.83)

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1 of the 61 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Rodt SA ˚, A ˚hle ´n K, Berg A, Rubin K, Reed RK. A novel physiological function for platelet-derived growth factor-BB in rat dermis. J Physiol 1996;495:193 -200.

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Authors
Reed, R. K., & Rubin, K.
Affiliations
  • University of Bergen (NO)
  • Uppsala University (SE)
Corresponding author
Reed, Rolf K.
ORCID
Venue
Cardiovascular Research
Publisher
Oxford University Press (OUP)
Published
2010-05-13
Volume
87
Issue
2
Pages
211-217
ISSN
  • 0008-6363 (ISSN-L)
  • 1755-3245
DOI
10.1093/cvr/cvq143
OpenAlex
W2153147895
Cited by
209
References
61
Citations by year
2026: 16 · 2025: 21 · 2024: 13 · 2023: 16 · 2022: 12 · 2021: 16 · 2020: 11 · 2019: 12 · 2018: 10 · 2017: 9 · 2016: 7 · 2015: 10 · 2014: 13 · 2013: 14 · 2012: 12
FWCI
1.23
Type
journal article
Language
en
Open access
closed
Locations
  • Cardiovascular Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Swedish Cancer Foundation
  • Vetenskapsrådet
  • Norges Forskningsråd
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
transcapillary exchange, interstitial fluid pressure, extracellular matrix, capillary filtration, lymphatic vessels, inflammation, trauma (physical injury), beta1 integrin, collagen, microfibrils, glycosaminoglycans, PDGF-BB, capillary permeability, colloid osmotic pressure, interstitial hydrostatic pressure
MeSH terms
Animals, Body Fluids, Capillaries, Capillary Permeability, Cytoskeleton, Edema, Endothelium, Vascular, Extracellular Matrix, Homeostasis, Humans, Hydrostatic Pressure, Inflammation, Models, Cardiovascular, Osmotic Pressure, Signal Transduction, Inflammation Mediators, Integrin beta1, Integrin alpha2beta1, Extracellular Fluid

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