The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Modulating fatty acid oxidation in heart failure
Open accessAbstract
In the advanced stages of heart failure, many key enzymes involved in myocardial energy substrate metabolism display various degrees of down-regulation. The net effect of the altered metabolic phenotype consists of reduced cardiac fatty oxidation, increased glycolysis and glucose oxidation, and rigidity of the metabolic response to changes in workload. Is this metabolic shift an adaptive mechanism that protects the heart or a maladaptive process that accelerates structural and functional derangement? The question remains open; however, the metabolic remodelling of the failing heart has induced a number of investigators to test the hypothesis that pharmacological modulation of myocardial substrate utilization might prove therapeutically advantageous. The present review addresses the effects of indirect and direct modulators of fatty acid (FA) oxidation, which are the best pharmacological agents available to date for 'metabolic therapy' of failing hearts. Evidence for the efficacy of therapeutic strategies based on modulators of FA metabolism is mixed, pointing to the possibility that the molecular/biochemical alterations induced by these pharmacological agents are more complex than originally thought. Much remains to be understood; however, the beneficial effects of molecules such as perhexiline and trimetazidine in small clinical trials indicate that this promising therapeutic strategy is worthy of further pursuit.
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Cites
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Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart
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Self-citationMorgan, E. E., Rennison, J. H., Young, M. E., McElfresh, T. A., Kung, T. A., Tserng, K.-Y., Hoit, B. D., Stanley, W. C., & Chandler, M. P. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01014.2005 · Cited by 86
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Carnitine and Acylcarnitines: Pharmacokinetic, Pharmacological and Clinical Aspects
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Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer
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A metabolic handbook for the COVID-19 pandemic
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Metadata
- Authors
- Lionetti, V., Stanley, W. C., & Recchia, F. A.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-02-02
- Volume
- 90
- Issue
- 2
- Pages
- 202-209
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2159697997
- Cited by
- 249
- References
- 6
- FWCI
- 11.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
