The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
A metabolic handbook for the COVID-19 pandemic
Open accessAbstract
For infectious-disease outbreaks, clinical solutions typically focus on efficient pathogen destruction. However, the COVID-19 pandemic provides a reminder that infectious diseases are complex, multisystem conditions, and a holistic understanding will be necessary to maximize survival. For COVID-19 and all other infectious diseases, metabolic processes are intimately connected to the mechanisms of disease pathogenesis and the resulting pathology and pathophysiology, as well as the host defence response to the infection. Here, I examine the relationship between metabolism and COVID-19. I discuss why preexisting metabolic abnormalities, such as type 2 diabetes and hypertension, may be important risk factors for severe and critical cases of infection, highlighting parallels between the pathophysiology of these metabolic abnormalities and the disease course of COVID-19. I also discuss how metabolism at the cellular, tissue and organ levels might be harnessed to promote defence against the infection, with a focus on disease-tolerance mechanisms, and speculate on the long-term metabolic consequences for survivors of COVID-19. The importance of metabolism in the course of SARS-Cov-2 infection is highlighted by the metabolic comorbidities of COVID-19. In this Perspective, Ayres provides insight into how current knowledge of immunometabolism and metabolic diseases can inform the understanding of COVID-19 pathology, and proposes potential metabolism-based clinical solutions.
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La certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19
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Cited by
da Silveira, M. P., da Silva Fagundes, K. K., Bizuti, M. R., Starck, É., Rossi, R. C., & de Resende e Silva, D. T. (2021) · Clinical and Experimental Medicine · doi:10.1007/s10238-020-00650-3 · Cited by 475
Global pandemics interconnected — obesity, impaired metabolic health and COVID-19
Stefan, N., Birkenfeld, A. L., & Schulze, M. B. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00462-1 · Cited by 452
Lam, S. M., Zhang, C., Wang, Z., Ni, Z., Zhang, S., Yang, S., Huang, X., Mo, L., Li, J., Lee, B., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00425-4 · Cited by 284
Metadata
- Authors
- Ayres, J. S.
- Venue
- Nature Metabolism
- Published
- 2020-06-30
- Volume
- 2
- Issue
- 7
- Pages
- 572-585
- ISSN
- 2522-5812 (ISSN-L)
- OpenAlex
- W3039377995
- Cited by
- 292
- References
- 109
- FWCI
- 7.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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