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Cited by 104Cardiac Fibrosis and RemodelingCardiovascular Function and Risk FactorsSodium Intake and Health

Low Carbohydrate/High-Fat Diet Attenuates Cardiac Hypertrophy, Remodeling, and Altered Gene Expression in Hypertension

Okere, Isidore C., Young, Martin E., McElfresh, Tracy A., Chess, David J., Sharov, Victor G., Sabbah, Hani N., Hoit, Brian D., Ernsberger, Paul +2 more·2006·Hypertension
DOI 10.1161/01.hyp.0000248430.26229.0f
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Abstract

The effects of dietary fat intake on the development of left ventricular hypertrophy and accompanying structural and molecular remodeling in response to hypertension are not understood. The present study compared the effects of a high-fat versus a low-fat diet on development of left ventricular hypertrophy, remodeling, contractile dysfunction, and induction of molecular markers of hypertrophy (ie, expression of mRNA for atrial natriuretic factor and myosin heavy chain β). Dahl salt-sensitive rats were fed either a low-fat (10% of total energy from fat) or a high-fat (60% of total energy from fat) diet on either low-salt or high-salt (6% NaCl) chow for 12 weeks. Hearts were analyzed for mRNA markers of ventricular remodeling and activities of the mitochondrial enzymes citrate synthase and medium chain acyl-coenzyme A dehydrogenase. Similar levels of hypertension were achieved with high-salt feeding in both diet groups (systolic pressure of ≈190 mm Hg). In hypertensive rats fed low-fat chow, left ventricular mass, myocyte cross-sectional area, and end-diastolic volume were increased, and ejection fraction was decreased; however, these effects were not observed with the high-fat diet. Hypertensive animals on low-fat chow had increased atrial natriuretic factor mRNA, myosin heavy chain isoform switching (α to β), and decreased activity of citrate synthase and medium chain acyl-coenzyme A dehydrogenase, which were all attenuated by high-fat feeding. In conclusion, increased dietary lipid intake can reduce cardiac growth, left ventricular remodeling, contractile dysfunction, and alterations in gene expression in response to hypertension.

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  • Isocaloric high-fat diets that are associated with reduced levels of insulin and leptin appear to attenuate LV hypertrophy in pressure overload hypertrophy and minimize LV remodeling in a rat infarct model.

    “For example, isocaloric high-fat diets that are associated with reduced levels of insulin and leptin appear to attenuate LV hypertrophy in pressure overload hypertrophy and minimize LV remodeling in a rat infarct model (239, 261, 262).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [262]

  • Isocaloric high-fat diets that do not lead to hyperinsulinemia or weight gain seem to attenuate pressure overload LVH.

    “Also, isocaloric high-fat diets that do not lead to hyperinsulinemia or weight gain seem to attenuate pressure overload LVH (261, 262).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [262]

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Authors
Okere, I. C., Young, M. E., McElfresh, T. A., Chess, D. J., Sharov, V. G., Sabbah, H. N., Hoit, B. D., Ernsberger, P., Chandler, M. P., & Stanley, W. C.
Affiliations
Agricultural Research Service (US)
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2006-12
Volume
48
Issue
6
Pages
1116-1123
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/01.hyp.0000248430.26229.0f
OpenAlex
W2161874357
Cited by
104
References
44
Citations by year
2026: 3 · 2025: 1 · 2024: 1 · 2023: 7 · 2022: 3 · 2021: 1 · 2020: 8 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 12
FWCI
6.40
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (HL 074237, HL-074259, P01HL074237, R01HL074259)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
Keywords
high-fat diet, low-fat diet, left ventricular hypertrophy, cardiac remodeling, dietary fat, atrial natriuretic peptide, beta-myosin heavy chain, citrate synthase, medium-chain acyl-CoA dehydrogenase, contractile dysfunction, Dahl salt-sensitive rats, salt intake, cardiac gene expression
MeSH terms
Animals, Blood Pressure, Disease Models, Animal, Heart, Hypertension, Myocardial Contraction, Atrial Natriuretic Factor, Gene Expression, Hypertrophy, Left Ventricular, Diet, Fat-Restricted, Myosin Heavy Chains, Ventricular Remodeling, Rats, Inbred Dahl, Diet, Carbohydrate-Restricted, Rats

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