The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles
Abstract
Vascular smooth muscle cells (VSMCs) are the stromal cells of the vascular wall, continually exposed to mechanical signals and biochemical components generated in the blood compartment. They are involved in all the physiological functions and the pathological changes taking place in the vascular wall. Owing to their contractile tonus, VSMCs of resistance vessels participate in the regulation of blood pressure and also in hypertension. VSMCs of conduit arteries respond to hypertension-induced increases in wall stress by an increase in cell protein synthesis (hypertrophy) and extracellular matrix secretion. These responses are mediated by complex signalling pathways, mainly involving RhoA and extracellular signal-regulated kinase1/2. Serum response factor and miRNA expression represent main mechanisms controlling the pattern of gene expression. Ageing also induces VSMC phenotypic modulation that could have influence on cell senescence and loss of plasticity and reprogramming. In the early stages of human atheroma, VSMCs support the lipid overload. Endocytosis/phagocytosis of modified low-density lipoproteins, free cholesterol, microvesicles, and apoptotic cells by VSMCs plays a major role in the progression of atheroma. Migration and proliferation of VSMCs in the intima also participate in plaque progression. The medial VSMC is the organizer of the inwardly directed angiogenic response arising from the adventitia by overexpressing vascular endothelial growth factor in response to lipid-stimulated peroxisome proliferator-activated receptor-γ, and probably also the organizer of the adventitial immune response by secreting chemokines. VSMCs are also involved in the response to proteolytic injury via their ability to activate blood-borne proteases, to secrete antiproteases, and to clear protease/antiprotease complexes.
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Cites
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
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Dynamic molecular processes mediate cellular mechanotransduction
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Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome
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Scavenger Receptors in Atherosclerosis: Beyond Lipid Uptake
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Structural and Genetic Bases of Arterial Stiffness
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Cited by
Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease
Lacolley, P., Regnault, V., Segers, P., & Laurent, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00003.2017 · Cited by 734
Self-citationVascular, glial, and lymphatic immune gateways of the central nervous system
Engelhardt, B., Carare, R. O., Bechmann, I., Flügel, A., Laman, J. D., & Weller, R. O. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1606-5 · Cited by 362
Bakker, E. N. T. P., Bacskai, B. J., Arbel-Ornath, M., Aldea, R., Bedussi, B., Morris, A. W. J., Weller, R. O., & Carare, R. O. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0273-8 · Cited by 353
Role of Vascular Smooth Muscle Cell Plasticity and Interactions in Vessel Wall Inflammation
Sorokin, V., Vickneson, K., Kofidis, T., Woo, C. C., Lin, X. Y., Foo, R., & Shanahan, C. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.599415 · Cited by 292
The arterial microenvironment: the where and why of atherosclerosis
Yurdagul, A., Finney, A. C., Woolard, M. D., & Orr, A. W. (2016) · Biochemical Journal · doi:10.1042/bj20150844 · Cited by 185
Metadata
- Authors
- Lacolley, P., Regnault, V., Nicoletti, A., Li, Z., & Michel, J.-B.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-03-31
- Volume
- 95
- Issue
- 2
- Pages
- 194-204
- ISSN
- 0008-6363 (ISSN-L)
- OpenAlex
- W2146038929
- Cited by
- 701
- References
- 10
- FWCI
- 21.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lacolley, P., Regnault, V., Nicoletti, A., Li, Z., & Michel, J.-B. (2012). The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles. Cardiovascular Research. https://doi.org/10.1093/cvr/cvs135
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
