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Cited by 292Atherosclerosis and Cardiovascular DiseasesCardiovascular, Neuropeptides, and Oxidative Stress ResearchCerebrovascular and Carotid Artery Diseases

Role of Vascular Smooth Muscle Cell Plasticity and Interactions in Vessel Wall Inflammation

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Sorokin, Vitaly, Vickneson, Keeran, Kofidis, Theo, Woo, Chin Cheng, Lin, Xiao Yun, Foo, Roger, Shanahan, Catherine M.·2020·Frontiers in Immunology
DOI 10.3389/fimmu.2020.599415PMC PMC7726011
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Abstract

The pathobiology of atherosclerotic disease requires further elucidation to discover new approaches to address its high morbidity and mortality. To date, over 17 million cardiovascular-related deaths have been reported annually, despite a multitude of surgical and nonsurgical interventions and advances in medical therapy. Existing strategies to prevent disease progression mainly focus on management of risk factors, such as hypercholesterolemia. Even with optimum current medical therapy, recurrent cardiovascular events are not uncommon in patients with atherosclerosis, and their incidence can reach 10–15% per year. Although treatments targeting inflammation are under investigation and continue to evolve, clinical breakthroughs are possible only if we deepen our understanding of vessel wall pathobiology. Vascular smooth muscle cells (VSMCs) are one of the most abundant cells in vessel walls and have emerged as key players in disease progression. New technologies, including in situ hybridization proximity ligation assays, in vivo cell fate tracing with the CreER T2 -loxP system and single-cell sequencing technology with spatial resolution, broaden our understanding of the complex biology of these intriguing cells. Our knowledge of contractile and synthetic VSMC phenotype switching has expanded to include macrophage-like and even osteoblast-like VSMC phenotypes. An increasing body of data suggests that VSMCs have remarkable plasticity and play a key role in cell-to-cell crosstalk with endothelial cells and immune cells during the complex process of inflammation. These are cells that sense, interact with and influence the behavior of other cellular components of the vessel wall. It is now more obvious that VSMC plasticity and the ability to perform nonprofessional phagocytic functions are key phenomena maintaining the inflammatory state and senescent condition and actively interacting with different immune competent cells.

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  • Vascular smooth muscle cells perform nonprofessional phagocytosis and take part in the development of atherosclerotic plaques.

    “Vascular smooth muscle cells are able to perform nonprofessional phagocytosis and take part in the development of atherosclerotic plaques [106].”

    From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [106]

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Cited by

Sorted by citations

Authors
Sorokin, V., Vickneson, K., Kofidis, T., Woo, C. C., Lin, X. Y., Foo, R., & Shanahan, C. M.
Affiliations
  • National University of Singapore (SG)
  • University of Dundee (GB)
  • National University Hospital (SG)
  • Agency for Science, Technology and Research (SG)
  • King's College London (GB)
Corresponding author
Sorokin, Vitaly
ORCID
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2020-11-26
Volume
11
Pages
599415-599415
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2020.599415
PMC
PMC7726011
OpenAlex
W3110282950
Cited by
292
References
5
Citations by year
2026: 30 · 2025: 47 · 2024: 69 · 2023: 55 · 2022: 63 · 2021: 28
FWCI
3.56
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • National University of Singapore (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
British Heart Foundation (RG/17/2/32808)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
Keywords
vascular smooth muscle cells, vascular inflammation, atherosclerosis, cellular senescence, proximity ligation assay, cell fate tracing
MeSH terms
Animals, Humans, Inflammation, Muscle, Smooth, Vascular, Vasculitis, Myocytes, Smooth Muscle, Atherosclerosis

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