Cited by 104Congenital heart defects researchCardiac Fibrosis and RemodelingWnt/β-catenin signaling in development and cancer

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Cell-cell interaction in the heart via Wnt/ -catenin pathway after cardiac injury

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Deb, A.·2014·Cardiovascular Research

DOI 10.1093/cvr/cvu054PMC PMC3989450

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Abstract

The adult mammalian heart predominantly comprises myocytes, fibroblasts, endothelial cells, smooth muscle cells, and epicardial cells arranged in a precise three-dimensional framework. Following cardiac injury, the spatial arrangement of cells is disrupted as different populations of cells are recruited to the heart in a temporally regulated manner. The alteration of the cellular composition of the heart after cardiac injury thus enables different phenotypes of cells to interact with each other in a spatio-temporal-dependent manner. It can be argued that the integrated study of such cellular interactions rather than the examination of single populations of cells can provide more insights into the biology of cardiac repair especially at an organ-wide level. Many signalling systems undoubtedly mediate such cross talk between cells after cardiac injury. The Wnt/β-catenin system plays an important role during cardiac development and disease. Here, we describe how cell populations in the heart after cardiac injury mediate their interactions via the Wnt/β-catenin pathway, determine how such interactions can affect a cardiac repair response and finally suggest an integrated approach to study cardiac cellular interactions.

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Authors: Deb, A.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Deb, A.
Venue: Cardiovascular Research
Publisher: Oxford University Press (OUP)
Published: 2014-03-03
Volume: 102
Issue: 2
Pages: 214-223
ISSN: 0008-6363 (ISSN-L)
DOI: 10.1093/cvr/cvu054
PMC: PMC3989450
OpenAlex: W2120472949
Cited by: 102
References: 68
Citations by year: 2026: 4 · 2025: 7 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 13 · 2020: 10 · 2019: 12 · 2018: 7 · 2017: 14 · 2016: 11 · 2015: 6 · 2014: 4
FWCI: 1.10
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Cardiovascular Research (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL102190)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Keywords: Wnt/β-catenin signaling, cell-cell interactions, cardiac injury, cardiac repair, cardiac fibroblasts, epicardial cells, endothelial cells, smooth muscle cells, cardiomyocytes
MeSH terms: Animals, Cell Communication, Heart, Heart Injuries, Humans, Signal Transduction, beta Catenin, Wnt Signaling Pathway

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Cell-cell interaction in the heart via Wnt/ -catenin pathway after cardiac injury

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