The origin of fibroblasts and mechanism of cardiac fibrosis
Open accessAbstract
Fibroblasts are at the heart of cardiac function and are the principal determinants of cardiac fibrosis. Nevertheless, cardiac fibroblasts remain poorly characterized in molecular terms. Evidence is evolving that the cardiac fibroblast is a highly heterogenic cell population, and that such heterogeneity is caused by the distinct origins of fibroblasts in the heart. Cardiac fibroblasts can derive either from resident fibroblasts, from endothelial cells via an endothelial–mesenchynmal transition or from bone marrow‐derived circulating progenitor cells, monocytes and fibrocytes. Here, we review the function and origin of fibroblasts in cardiac fibrosis.NB. The information given is correct. J. Cell. Physiol. 225: 631–637, 2010. © 2010 Wiley‐Liss, Inc.
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Cardiac fibrosis is characterized by cardiac fibroblast over-proliferation, myofibroblast activation, and increased deposition of fibrous extracellular matrix proteins.
“Cardiac fibrosis is the scarring process that is characterized by cardiac fibroblast (CF) over-proliferation, myoFB activation, and increased deposition of fibrous ECM proteins [56].”
From Cardiovascular disease models: A game changing paradigm in drug discovery and screening (2019) · cites this paper as [56]
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Flagged first, then by citations
Cited by
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- Authors
- Krenning, G., Zeisberg, E. M., & Kalluri, R.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Kalluri, Raghu
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2010-12
- Volume
- 225
- Issue
- 3
- Pages
- 631-637
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- PMC
- PMC3098503
- OpenAlex
- W2104483699
- Cited by
- 601
- References
- 105
- Citations by year
- 2026: 18 · 2025: 18 · 2024: 19 · 2023: 33 · 2022: 31 · 2021: 47 · 2020: 56 · 2019: 43 · 2018: 39 · 2017: 58 · 2016: 56 · 2015: 42 · 2014: 38 · 2013: 36 · 2012: 45
- FWCI
- 5.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Funders
- National Science Foundation
- American Heart Association
- National Cancer Institute (K08CA129204, CA 125550, R01CA125550)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-55001, R01DK055001)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- cardiac fibroblasts, myocardial fibrosis, fibroblast origin, fibroblast heterogeneity, endothelial-to-mesenchymal transition, bone marrow progenitor cells, monocytes, fibrocytes
- MeSH terms
- Animals, Coronary Vessels, Extracellular Matrix, Fibroblasts, Fibrosis, Heart Diseases, Humans, Morphogenesis, Myocardial Contraction, Myocardium, Phenotype, Stem Cells, Signal Transduction, Neovascularization, Physiologic, Cell Lineage, Endothelial Cells, Cell Transdifferentiation, Excitation Contraction Coupling
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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