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Cited by 289Congenital heart defects researchPluripotent Stem Cells ResearchHippo pathway signaling and YAP/TAZ

YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo

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Monroe, Tanner O., Hill, Matthew C., Morikawa, Yuka, Leach, John P., Heallen, Todd, Cao, Shuyi, Krijger, Peter H.L., de Laat, Wouter +3 more·2019·Developmental Cell
DOI 10.1016/j.devcel.2019.01.017PMC PMC6435425
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Abstract

Specialized adult somatic cells, such as cardiomyocytes (CMs), are highly differentiated with poor renewal capacity, an integral reason underlying organ failure in disease and aging. Among the least renewable cells in the human body, CMs renew approximately 1% annually. Consistent with poor CM turnover, heart failure is the leading cause of death. Here, we show that an active version of the Hippo pathway effector YAP, termed YAP5SA, partially reprograms adult mouse CMs to a more fetal and proliferative state. One week after induction, 19% of CMs that enter S-phase do so twice, CM number increases by 40%, and YAP5SA lineage CMs couple to pre-existing CMs. Genomic studies showed that YAP5SA increases chromatin accessibility and expression of fetal genes, partially reprogramming long-lived somatic cells in vivo to a primitive, fetal-like, and proliferative state.

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  • YAP is necessary and sufficient for hepatocyte reprogramming into ductal cells.

    “YAP, the main transducer of the Hippo pathway, has been reported to be necessary and sufficient for hepatocyte reprogramming into ductal cells10,11.”

    From HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury (2025) · cites this paper as [11]

    The Introduction identifies YAP as a Hippo-pathway effector, supporting that background part of the sentence. The Discussion section on YAP, ploidy and cell-cycle progression mentions hepatocyte proliferation, but neither it nor the other passages found addresses whether YAP is necessary and sufficient to reprogram hepatocytes into ductal cells. No page numbers were available in our copy. (LLM, conf=0.82)

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Authors
Monroe, T. O., Hill, M. C., Morikawa, Y., Leach, J. P., Heallen, T., Cao, S., Krijger, P. H. L., de Laat, W., Wehrens, X. H. T., Rodney, G. G., & Martin, J. F.
Affiliations
  • Baylor College of Medicine (US)
  • Royal Netherlands Academy of Arts and Sciences (NL)
Corresponding author
Martin, James F.
ORCID
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2019-03
Volume
48
Issue
6
Pages
765-779.e7
ISSN
1534-5807 (ISSN-L)
DOI
10.1016/j.devcel.2019.01.017
PMC
PMC6435425
OpenAlex
W2912091946
Cited by
289
References
10
Citations by year
2026: 37 · 2025: 53 · 2024: 37 · 2023: 37 · 2022: 37 · 2021: 40 · 2020: 32 · 2019: 14 · 2018: 1
FWCI
10.08
Type
journal article
Language
en
Open access
Licence
Locations
  • Developmental Cell (publishedVersion)
  • PubMed (publishedVersion)
  • KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
  • KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
Funders
  • Intellectual and Developmental Disability Research Center (1U54 HD083092, HL 089898, HL 091947, HL 117641, HL 129570, AR 061370, F31HL136065)
  • NICHD
  • Baylor College of Medicine (U54 HG006348)
  • NIH (DE 023177, HL 127717, HL 130804, HL 118761)
  • Vivian L. Smith Foundation
  • MacDonald Research Fund (16RDM001)
  • LeDucq Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Keywords
YAP, Hippo signaling pathway, cardiomyocytes, chromatin accessibility, cellular reprogramming, cardiomyocyte proliferation, fetal gene expression, cardiomyocyte renewal, heart failure, somatic cell reprogramming
MeSH terms
Gain of Function Mutation, YAP-Signaling Proteins, Action Potentials, Aging, Animals, Cell Cycle, Chromatin, Diploidy, Enhancer Elements, Genetic, Heart, Cardiomegaly, Heart Ventricles, Mice, Transgenic, Phosphoproteins, Promoter Regions, Genetic, Gene Expression Regulation, Developmental, Cell Cycle Proteins, Transcription Factor AP-1, Cell Lineage, Transgenes, Myocytes, Cardiac, Organogenesis, Adaptor Proteins, Signal Transducing, Cell Proliferation

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