The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Brahmi rasayana Improves Learning and Memory in Mice
Open accessAbstract
Cure of cognitive disorders such as amnesia, attention deficit and Alzheimer's disease is still a nightmare in the field of medicine. Nootropic agents such as piracetam, aniracetam and choline esterase inhibitors like Donepezil are being used to improve memory, mood and behavior, but the resulting side effects associated with these agents have made their use limited. The present study was undertaken to assess the potential of Brahmi rasayana (BR) as a memory enhancer. BR (100 and 200 mg kg(-1) p.o.) was administered for eight successive days to both young and aged mice. Elevated plus maze and passive-avoidance paradigm were employed to evaluate learning and memory parameters. Scopolamine (0.4 mg kg(-1) i.p.) was used to induce amnesia in mice. The effect of BR on whole brain AChE activity was also assessed. Piracetam (200 mg kg(-1) i.p.) was used as a standard nootropic agent. BR significantly improved learning and memory in young mice and reversed the amnesia induced by both scopolamine (0.4 mg kg(-1) i.p.) and natural aging. BR significantly decreased whole brain acetyl cholinesterase activity. BR might prove to be a useful memory restorative agent in the treatment of dementia seen in elderly.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Besides, bacosides has been proven for its antioxidant and anti-inflammatory effects [75] bacosides also attenuated the retrograde amnesia produced by immobilization induced stress, electroconvulsive shock and scopolamine [76].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [76]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A new and rapid colorimetric determination of acetylcholinesterase activity
Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961) · Biochemical Pharmacology · doi:10.1016/0006-2952(61)90145-9 · Cited by 27,221
A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease
Rogers, S. L., Farlow, M. R., Doody, R. S., Mohs, R., Friedhoff, L. T., & Donepezil Study Group* (1998) · Neurology · doi:10.1212/wnl.50.1.136 · Cited by 1,618
Cinnamon improves glucose and lipids of people with type 2 diabetes
Khan, A., Safdar, M., Ali Khan, M. M., Khattak, K. N., & Anderson, R. A. (2003) · Diabetes Care · doi:10.2337/diacare.26.12.3215 · Cited by 981
Ayurveda and Traditional Chinese Medicine: A Comparative Overview
Patwardhan, B., Warude, D., Pushpangadan, P., & Bhatt, N. (2005) · Evidence-Based Complementary and Alternative Medicine · doi:10.1093/ecam/neh140 · Cited by 856
Immunomodulatory and antitumor activity of Piper longum Linn. and piperine
Sunila, E. S., & Kuttan, G. (2003) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2003.10.016 · Cited by 534
Cummings, J. L. (2002) · JAMA · doi:10.1001/jama.287.18.2335 · Cited by 443
Itoh, J., NABESHIMA, T., & Kameyama, T. (1990) · Psychopharmacology · doi:10.1007/bf02253713 · Cited by 411
Chronic Effects of Brahmi (Bacopa monnieri) on Human Memory
Roodenrys, S. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00419-5 · Cited by 313 · cited 1×
“monnieri are reported to potentiate human long-term memory (24) and exhibit anti-stress activity (23).”
BackgroundMemory enhancing activity of Glycyrrhiza glabra in mice
Dhingra, D., Parle, M., & Kulkarni, S. K. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.01.016 · Cited by 307
Self-citationVijayakumar, R. S., Surya, D., & Nalini, N. (2004) · Redox Report · doi:10.1179/135100004225004742 · Cited by 286
In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases
Li, Y., Xu, C., Zhang, Q., Liu, J., & Tan, R. X. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.01.020 · Cited by 258
Effects of the novel compound aniracetam (Ro 13-5057) upon impaired learning and memory in rodents
Cumin, R., Bandle, E. F., Gamzu, E., & Haefely, W. E. (1982) · Psychopharmacology · doi:10.1007/bf00432244 · Cited by 228
ANTI-INFLAMMATORY ACTIVITY OF PIPERINE
Mujumdar, A. M., Dhuley, J. N., Vk, D., RAMAN, P. H., & Suresh Ramnath, N. A. I. K. (1990) · Japanese Journal of Medical Science and Biology · doi:10.7883/yoken1952.43.95 · Cited by 175
Chowdhuri, D. K., Parmar, D., Kakkar, P., Shukla, R., Seth, P. K., & Srimal, R. C. (2002) · Phytotherapy Research · doi:10.1002/ptr.1023 · Cited by 162
Cholinesterase inhibitors in the treatment of dementia.
Ellis, J. M. (2005) · PubMed · Cited by 161
Blazer, D. G., Federspiel, C. F., Ray, W. A., & Schaffner, W. (1983) · Journal of Gerontology · doi:10.1093/geronj/38.1.31 · Cited by 158
PHARMACOLOGICAL STUDIES OF CARDAMOM OIL IN ANIMALS
Al-Zuhair, H. H. (1996) · Pharmacological Research · doi:10.1006/phrs.1996.0067 · Cited by 156
Sensitivity of fungi isolated from onychomycosis to Eugenia cariophyllata essential oil and eugenol
Gayoso, C. W., Lima, E. D. O., Oliveira, V. T. D. S., Pereira, F. D. O., de Souza, E. L., Lima, I. O., & Navarro, D. (2005) · Fitoterapia · doi:10.1016/j.fitote.2004.12.005 · Cited by 116
Pro‐healing effect of Cinnamomum zeylanicum bark
Kamath, J. V., Rana, A. C., & Chowdhury, A. R. (2003) · Phytotherapy Research · doi:10.1002/ptr.1293 · Cited by 112
Jn, D. (1999) · PubMed · Cited by 105
Traditional Indian Systems of Medicine
Lodha, R., & Bagga, A. (2000) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.v29n1p37 · Cited by 102
Improvement of Mouse Memory by Myristica fragrans Seeds
Parle, M., Dhingra, D., & Kulkarni, S. K. (2004) · Journal of Medicinal Food · doi:10.1089/1096620041224193 · Cited by 101
Self-citationChaudhury, R. R., & Rafei, U. (2002) · Medical Entomology and Zoology · Cited by 96
ANIMAL MODELS FOR TESTING MEMORY
Parle, M., & Singh, N. (2004) · Cited by 96
Self-citationJewart, R. D., Green, J., Lu, C.-J., Cellar, J. S., & Tune, L. E. (2005) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200504000-00009 · Cited by 92
Antimutagenic properties of bell and black peppers
Hamss, R. E., Idaomar, M., Alonso-Moraga, Á., & Serrano, A. M. (2002) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00216-8 · Cited by 82
Anticonvulsant activity of piperine on seizures induced by excitatory amino acid receptor agonists.
D’Hooge, R., Pei, Y.-Q., Raes, A. L., Lebrun, P., Bogaert, P. P. V., & Deyn, P. P. D. (1996) · PubMed · Cited by 77
Piracetam Improves Cognitive Performance by Restoring Neurochemical Deficits of the Aged Rat Brain
Scheuer, K., Rostock, A., Bartsch, R., & Müller, W. E. G. (1999) · Pharmacopsychiatry · doi:10.1055/s-2007-979231 · Cited by 67
Immunotoxicological effects of piperine in mice
DOGRA, R. K. S., Khanna, S., & Shanker, R. (2004) · Toxicology · doi:10.1016/j.tox.2003.10.006 · Cited by 67
Ability of eugenol to reduce tongue edema induced by Dieffenbachia picta Schott in mice
Dip, E. C., Pereira, N. Á., & Fernandes, P. D. (2004) · Toxicon · doi:10.1016/j.toxicon.2004.03.005 · Cited by 37
Memory enhancing activity of Glycyrrhiza glabra in mice
Dhingra, D. (2004) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(04)00045-5 · Cited by 35
Swim everyday to keep dementia away.
Parle, M., Mani, V., & Singh, N. (2005) · Europe PMC (PubMed Central) · Cited by 34
Self-citationJewart, R. D. (2005) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.13.4.324 · Cited by 32
Neurochemical Basis Of Learning And Memory
Parle, M., Dhingra, D., & Kulkarni, S. K. (2004) · Indian Journal of Pharmaceutical Sciences · Cited by 31
Self-citationEffects of Medicinal Herb Tea on the Smoking Cessation and Reducing Smoking Withdrawal Symptoms
Lee, H., & Lee, J. (2005) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x05002722 · Cited by 30
Itoh, J., Nabeshima, T., & Kameyama, T. (1990) · Cited by 30
Effects of piperine on memory and behavior mediated via monoamine neurotransmiters
Joshi, H., & Parle, M. (2005) · Medical Entomology and Zoology · doi:10.11339/jtm.22.39 · Cited by 18
Self-citationRISK FACTORS FOR ALZHEIMER'S DISEASE
Katzman, R., & Kawas, C. H. (1998) · Cited by 12
Flagged first, then by citations
Cited by
Sorted by citations
Effect of Fagonia Arabica (Dhamasa) on in vitro thrombolysis
Prasad, S., Kashyap, R. S., Deopujari, J. Y., Purohit, H. J., Taori, G. M., & Daginawala, H. F. (2007) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-7-36 · Cited by 226
Peterson, C. T. (2020) · Journal of Evidence-Based Integrative Medicine · doi:10.1177/2515690x20957225 · Cited by 160
Brahmi (Bacopa monnieri): An ayurvedic herb against the Alzheimer's disease
Dubey, T., & Chinnathambi, S. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.108153 · Cited by 151
Plant-based Rasayana drugs from Ayurveda
Balasubramani, S. P., Venkatasubramanian, P., Kukkupuni, S. K., & Patwardhan, B. (2011) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-011-0659-5 · Cited by 125
Ramnath, V., Rekha, P. S., & Sujatha, K. (2007) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nel116 · Cited by 119
Metadata
- Authors
- Joshi, H., & Parle, M.
- Affiliations
- Guru Jambheshwar University of Science and Technology (IN)
- Venue
- Evidence-based Complementary and Alternative Medicine
- Publisher
- Wiley
- Published
- 2006-01
- Volume
- 3
- Issue
- 1
- Pages
- 79-85
- ISSN
- 1741-427X (ISSN-L)
- 1741-4288
- PMC
- PMC1375237
- OpenAlex
- W2107422447
- Cited by
- 124
- References
- 36
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 9 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 8 · 2013: 7 · 2012: 12
- FWCI
- 21.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Keywords
- memory enhancement, learning, scopolamine-induced amnesia, acetylcholinesterase activity, aging, nootropic drugs, piracetam, cognitive disorders, dementia, traditional medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
