Cited by 151Medicinal Plants and NeuroprotectionAlzheimer's disease research and treatmentsPhytochemicals and Medicinal Plants

Brahmi (Bacopa monnieri): An ayurvedic herb against the Alzheimer's disease

Dubey, Tushar, Chinnathambi, Subashchandrabose·2019·Archives of Biochemistry and Biophysics

Abstract

Ayurveda is the medicinal science, dealing with utilization of naturally available plant products for treatment. A wide variety of neuroprotective herbs have been reported in Ayurveda. Brahmi, Bacopa monnieri is a nootropic ayurvedic herb known to be effective in neurological disorders from ancient times. Numerous approaches including natural and synthetic compounds have been applied against Alzheimer's disease. Amyloid-β and Tau are the hallmarks proteins of several neuronal dysfunctions resulting in Alzheimer's disease. Tau is a microtubule-associated protein known to be involved in progression of Alzheimer's disease. The generation of reaction oxygen species, increased neuroinflammation and neurotoxicity are the major physiological dysfunctions associated with Tau aggregates, which leads to dementia and behavioural deficits. Bacoside A, Bacoside B, Bacosaponins, Betulinic acid, etc; are the bioactive component of Brahmi belonging to various chemical families. Each chemical component known have its significant role in neuroprotection. The neuroprotective properties of Brahmi and its bioactive components including reduction of ROS, neuroinflammation, aggregation inhibition of Amyloid-β and improvement of cognitive and learning behaviour. Here on basis of earlier studies we hypothesize the inhibitory role of Brahmi against Tau-mediated toxicity. The overall studies have concluded that Brahmi can be used as a lead formulation for treatment of Alzheimer's disease and other neurological disorders.

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Crossref · 10.1016/j.abb.2019.108153

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Authors
Dubey, T., & Chinnathambi, S.
Affiliations
National Chemical Laboratory (IN)
Corresponding author
Chinnathambi, Subashchandrabose
Venue
Archives of Biochemistry and Biophysics
Publisher
Elsevier BV
Published
2019-11
Volume
676
Pages
108153
ISSN
0003-9861 (ISSN-L)
OpenAlex
W2981039403
Cited by
151
References
106
Citations by year
2026: 21 · 2025: 39 · 2024: 25 · 2023: 23 · 2022: 17 · 2021: 16 · 2020: 10
FWCI
2.20
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Biochemistry and Biophysics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Council of Scientific and Industrial Research, India
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
Keywords
Bacopa monnieri, Alzheimer's disease, Ayurvedic herbs, neuroprotection, tau aggregation, amyloid-beta, reactive oxygen species, neuroinflammation, bacosides, betulinic acid, cognitive impairment
MeSH terms
Alzheimer Disease, Animals, Antioxidants, Humans, Medicine, Ayurvedic, Plant Extracts, Bacopa

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