Brahmi (Bacopa monnieri): An ayurvedic herb against the Alzheimer's disease
Abstract
Ayurveda is the medicinal science, dealing with utilization of naturally available plant products for treatment. A wide variety of neuroprotective herbs have been reported in Ayurveda. Brahmi, Bacopa monnieri is a nootropic ayurvedic herb known to be effective in neurological disorders from ancient times. Numerous approaches including natural and synthetic compounds have been applied against Alzheimer's disease. Amyloid-β and Tau are the hallmarks proteins of several neuronal dysfunctions resulting in Alzheimer's disease. Tau is a microtubule-associated protein known to be involved in progression of Alzheimer's disease. The generation of reaction oxygen species, increased neuroinflammation and neurotoxicity are the major physiological dysfunctions associated with Tau aggregates, which leads to dementia and behavioural deficits. Bacoside A, Bacoside B, Bacosaponins, Betulinic acid, etc; are the bioactive component of Brahmi belonging to various chemical families. Each chemical component known have its significant role in neuroprotection. The neuroprotective properties of Brahmi and its bioactive components including reduction of ROS, neuroinflammation, aggregation inhibition of Amyloid-β and improvement of cognitive and learning behaviour. Here on basis of earlier studies we hypothesize the inhibitory role of Brahmi against Tau-mediated toxicity. The overall studies have concluded that Brahmi can be used as a lead formulation for treatment of Alzheimer's disease and other neurological disorders.
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Neuroprotective triterpenoidal saponins (bacoside-A, bacoside-B, bacosaponins, betulinic acid) play a major role in ameliorating memory and cognitive functions.
“Moreover, several neuroprotective triterpenoidal saponins such as bacoside-A, bacoside-B, bacosaponins, and betulinic acid play a major role in ameliorating memory and cognitive functions [124,126].”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [124]
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- Authors
- Dubey, T., & Chinnathambi, S.
- Affiliations
- National Chemical Laboratory (IN)
- Corresponding author
- Chinnathambi, Subashchandrabose
- Venue
- Archives of Biochemistry and Biophysics
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 676
- Pages
- 108153
- ISSN
- 0003-9861 (ISSN-L)
- OpenAlex
- W2981039403
- Cited by
- 151
- References
- 106
- Citations by year
- 2026: 21 · 2025: 39 · 2024: 25 · 2023: 23 · 2022: 17 · 2021: 16 · 2020: 10
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Biochemistry and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Council of Scientific and Industrial Research, India
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Keywords
- Bacopa monnieri, Alzheimer's disease, Ayurvedic herbs, neuroprotection, tau aggregation, amyloid-beta, reactive oxygen species, neuroinflammation, bacosides, betulinic acid, cognitive impairment
- MeSH terms
- Alzheimer Disease, Animals, Antioxidants, Humans, Medicine, Ayurvedic, Plant Extracts, Bacopa
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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