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Metabolomic Analysis in Inflammatory Bowel Disease: A Systematic Review
Abstract
Background and Aims: The inflammatory bowel diseases [IBD], Crohn’s disease and ulcerative colitis, are chronic, idiopathic gastrointestinal diseases. Although their precise aetiology is unknown, it is thought to involve a complex interaction between genetic predisposition and an abnormal host immune response to environmental exposures, probably microbial. Microbial dysbiosis has frequently been documented in IBD. Metabolomics [the study of small molecular intermediates and end products of metabolism in biological samples] provides a unique opportunity to characterize disease-associated metabolic changes and may be of particular use in quantifying gut microbial metabolism. Numerous metabolomic studies have been undertaken in IBD populations, identifying consistent alterations in a range of molecules across several biological matrices. This systematic review aims to summarize these findings. Methods: A comprehensive, systematic search was carried out using Medline and Embase. All studies were reviewed by two authors independently using predefined exclusion criteria. Sixty-four relevant papers were assessed for quality and included in the review. Results: Consistent metabolic perturbations were identified, including increases in levels of branched chain amino acids and lipid classes across stool, serum, plasma and tissue biopsy samples, and reduced levels of microbially modified metabolites in both urine [such as hippurate] and stool [such as secondary bile acids] samples. Conclusions: This review provides a summary of metabolomic research in IBD to date, highlighting underlying themes of perturbed gut microbial metabolism and mammalian–microbial co-metabolism associated with disease status.
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“BA metabolism is defective in patients with IBD, as indicated by increased levels of primary BAs (PBAs) and/or their conjugated forms, accompanied by decreased levels of second BAs (SBAs) (Lavelle and Sokol, 2020; Biagioli et al., 2021; Gallagher et al., 2021).”
From Bacteroides dorei BDX-01 alleviates DSS-induced experimental colitis in mice by regulating intestinal bile salt hydrolase activity and the FXR-NLRP3 signaling pathway (2023) · cites this paper as Gallagher et al., 2021
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Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
Principal component analysis: A review and recent developments
Jolliffe, I. T., & Cadima, J. (2016) · Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences · doi:10.1098/rsta.2015.0202 · Cited by 10,117
den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048
Host-gut microbiota metabolic interactions
Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760
Self-citationWhiting, P., Rutjes, A. W., Reitsma, J. B., Bossuyt, P. M., & Kleijnen, J. (2003) · BMC Medical Research Methodology · doi:10.1186/1471-2288-3-25 · Cited by 3,592
Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases
Lloyd-Price, J., Arze, C., Ananthakrishnan, A. N., Schirmer, M., Avila-Pacheco, J., Poon, T. W., Andrews, E., Ajami, N. J., Bonham, K. S., Brislawn, C. J., et al. (2019) · Nature · doi:10.1038/s41586-019-1237-9 · Cited by 3,143
Gut microbiota functions: metabolism of nutrients and other food components
Rowland, I., Gibson, G., Heinken, A., Scott, K., Swann, J., Thiele, I., & Tuohy, K. (2018) · European Journal of Nutrition · doi:10.1007/s00394-017-1445-8 · Cited by 2,878
Bile salt biotransformations by human intestinal bacteria
Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829
Research works printed but not linked: 2
- Qi, 2020, High, Genomics
- Machiels, 2014, A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis, Gut, 63, 1275, 10.1136/gutjnl-2013-304833 · DOI · Paper page
Cited by
Sorted by citations
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Qiu, S., Cai, Y., Yao, H., Lin, C., Xie, Y., Tang, S., & Zhang, A. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01399-3 · Cited by 993
Dysbiosis in Inflammatory Bowel Disease: Pathogenic Role and Potential Therapeutic Targets
Santana, P. T., Rosas, S. L. B., Ribeiro, B. E., Marinho, Y., & de Souza, H. S. P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073464 · Cited by 359
Ning, L., Zhou, Y., Sun, H. L., Zhang, Y., Shen, C., Wang, Z., Xuan, B., Zhao, Y., Ma, Y., Yan, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42788-0 · Cited by 334
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Fogelson, K. A., Dorrestein, P. C., Zarrinpar, A., & Knight, R. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.02.022 · Cited by 177
The Emerging Role of Bile Acids in the Pathogenesis of Inflammatory Bowel Disease
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Deciphering the different phases of preclinical inflammatory bowel disease
Rudbaek, J. J., Agrawal, M., Torres, J., Mehandru, S., Colombel, J., & Jess, T. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00854-4 · Cited by 135
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Hov, J. R., & Karlsen, T. H. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00690-y · Cited by 133
Novel Insights into the Pathogenesis of Inflammatory Bowel Diseases
Calvez, V., Puca, P., Vincenzo, F. D., GAUDIO, A. D., Bartocci, B., Murgiano, M., Iaccarino, J., Parand, E., Napolitano, D., Pugliese, D., et al. (2025) · Biomedicines · doi:10.3390/biomedicines13020305 · Cited by 126
Yuan, S.-N., Wang, M.-X., Han, J.-L., Feng, C.-Y., Wang, M., Wang, M., Sun, J., Li, N., Simal‐Gándara, J., & Liu, C. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154702 · Cited by 113
Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases
Kamel, M. S., Aleya, S., Alsubih, M., & Aleya, L. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14020217 · Cited by 99
Metabolomics Insights into Inflammatory Bowel Disease: A Comprehensive Review
Aldars‐García, L., Gisbert, J. P., & Chaparro, M. (2021) · Pharmaceuticals · doi:10.3390/ph14111190 · Cited by 94
Iyer, N. R., & Corr, S. C. (2021) · Nutrients · doi:10.3390/nu13124259 · Cited by 83
Cao, C., Wang, L., Ai, C., Gong, G., Wang, Z., Huang, L., Song, S., & Zhu, B. (2022) · Food & Function · doi:10.1039/d2fo01283a · Cited by 81
The role of fecal sulfur metabolome in inflammatory bowel diseases
Walker, A., & Schmitt‐Kopplin, P. (2021) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2021.151513 · Cited by 69
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Hu, X., He, Z., Zhao, C., He, Y., Qiu, M., Xiang, K., Zhang, N., & Fu, Y. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.02.009 · Cited by 72
Fu, Y., Peng, X., Zhang, C., Jiang, Q.-X., Li, C., Paulsen, B. S., Rise, F., Huang, C., Feng, B., Li, L., et al. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120626 · Cited by 66
Metabolomic epidemiology offers insights into disease aetiology
Fuller, H., Zhu, Y., Nicholas, J. C., Chatelaine, H., Drzymalla, E., Sarvestani, A. K., Julián‐Serrano, S., Tahir, U. A., Sinnott-Armstrong, N., Raffield, L. M., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00903-x · Cited by 63
Microbiome and metabolome in inflammatory bowel disease
Upadhyay, K. G., Desai, D., Ashavaid, T. F., & Dherai, A. J. (2022) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16043 · Cited by 61
Tian, Z., Zhuang, X., Zhuo, S., Zhu, Y., Hu, S., Zhao, M., Tang, C., Zhang, Z., Li, X., Ma, R., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.04.014 · Cited by 59
Radhakrishnan, S. T., Alexander, J. L., Mullish, B. H., Gallagher, K., Powell, N., Hicks, L., Hart, A. L., Li, J. V., Marchesi, J. R., & Williams, H. R. T. (2021) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16656 · Cited by 53
Self-citationDiscovery of disease-adapted bacterial lineages in inflammatory bowel diseases
Kumbhari, A., Cheng, T. N. H., Ananthakrishnan, A. N., Kochar, B., Burke, K. E., Shannon, K., Lau, H., Xavier, R. J., & Smillie, C. S. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.05.022 · Cited by 54
Enteral nutrition promotes the remission of colitis by gut bacteria-mediated histidine biosynthesis
Zeng, W., Wu, J., Xie, H., Xu, H., Liang, D., He, Q., Yang, X., Liu, C., Gong, J., Zhang, Q., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2023.104959 · Cited by 53
Metabolomics as a Promising Resource Identifying Potential Biomarkers for Inflammatory Bowel Disease
Bauset, C., Gisbert-Ferrándiz, L., & Cosín‐Roger, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10040622 · Cited by 50
Han, M., Liang, J., Hou, M., Liu, Y., Li, H., & Gao, Z. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c00365 · Cited by 41
Scanu, M., Toto, F., Petito, V., Masi, L., Fidaleo, M., Puca, P., Baldelli, V., Reddel, S., Vernocchi, P., Pani, G., et al. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1366192 · Cited by 42
Faecal Metabolomics in Paediatric Inflammatory Bowel Disease: A Systematic Review
Jagt, J. Z., Verburgt, C. M., de Vries, R., de Boer, N. K. H., Benninga, M. A., de Jonge, W. J., Limbergen, J. V., & de Meij, T. G. J. (2022) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjac079 · Cited by 39
IBD metabonomics predicts phenotype, disease course, and treatment response
Bjerrum, J. T., Wang, Y., Seidelin, J. B., & Nielsen, O. H. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103551 · Cited by 37
Sun, X., Chen, Z., Yu, L., Zeng, W., Sun, B., Fan, H., & Bai, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1205323 · Cited by 33
“BA metabolism is defective in patients with IBD, as indicated by increased levels of primary BAs (PBAs) and/or their conjugated forms, accompanied by decreased levels of second BAs (SBAs) (Lavelle and Sokol, 2020; Biagioli et al., 2021; Gallagher et al., 2021).”
BackgroundNyström, N., Prast‐Nielsen, S., Correia, M. S. P., Globisch, D., Engstrand, L. G., Schuppe‐Koistinen, I., & Halfvarson, J. (2022) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjac149 · Cited by 31
Zhou, R., Huang, Y., Tian, C., Yang, Y., Zhang, Z., & He, K. (2023) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x23500945 · Cited by 30
Janker, L., Schuster, D., Bortel, P., Hagn, G., Meier, S. M., Mohr, T. T., Mader, J. C., Slany, A., Bileck, A., Brunmair, J., et al. (2023) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjad052 · Cited by 27
Microbiota-derived metabolites in inflammatory bowel disease
Guggeis, M. A., Harris, D. M. M., Welz, L., Rosenstiel, P. C., & Aden, K. (2025) · Seminars in Immunopathology · doi:10.1007/s00281-025-01046-9 · Cited by 31
Inflammation and Organic Cation Transporters Novel (OCTNs)
Pochini, L., Galluccio, M., Console, L., Scalise, M., Eberini, I., & Indiveri, C. (2024) · Biomolecules · doi:10.3390/biom14040392 · Cited by 25
Multi-omics in Crohn's disease: New insights from inside
Mu, C., Zhao, Q., Zhao, Q. C., Yang, L., Pang, X., Liu, T., Li, X., Wang, B., Fung, S., & Cao, H. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.05.010 · Cited by 26
Wang, B., Han, D. W., Hu, X., Chen, J., Liu, Y., & Wu, J. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127865 · Cited by 24
Zeng, X., Ren, D., Li, D., Du, H., & Yang, X. (2022) · Food & Function · doi:10.1039/d2fo02257e · Cited by 22
Ge, C., Lü, Y., Shen, Z., Lu, Y., Liu, X., Zhang, M., Liu, Y., Shen, H., & Zhu, L. (2025) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaf020 · Cited by 21
Liu, M., Guo, S., & Wang, L. (2024) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848241239580 · Cited by 19
Systematic Review of Recent Lipidomics Approaches Toward Inflammatory Bowel Disease
Lee, E. G., Yoon, Y. C., Yoon, J., Lee, S. J., Oh, Y., & Kwon, S. W. (2021) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2021.125 · Cited by 19
Wei, Z., Wang, Y., Shi, Z., Zhou, N., Ren, G., Hao, X., Zou, L., & Yao, Y. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c05220 · Cited by 19
Wang, S., Huang, J., Liu, F., Tan, K. S., Deng, L., Lin, Y., & Tan, W. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s344990 · Cited by 20
Strauss, J., Haskey, N., Ramay, H. R., Ghosh, T. S., Taylor, L., Yousuf, M., Ohland, C., McCoy, K. D., Ingram, R. J. M., Ghosh, S. K., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087323 · Cited by 19
Cortes, G. M., Marcialis, M. A., Bardanzellu, F., Corrias, A., Fanos, V., & Mussap, M. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.856165 · Cited by 21
Huang, Q., Wu, X., Gu, Y., Wang, T., Zhan, Y., Chen, J., Zeng, Z., Lv, Y., Zhao, J., & Xie, J. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.839259 · Cited by 18
Zhou, D., Liu, X., Lan, L., Yu, W., Qiu, R., Wu, J., Teng, C., Huang, L., Yu, C., & Zeng, Y. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e16613 · Cited by 18
Zheng, L. (2022) · World Journal of Clinical Cases · doi:10.12998/wjcc.v10.i30.10823 · Cited by 17
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Wu, X., Pan, L., Wang, W., Xu, J., Ai, R., Wen, Q., Cui, B., & Zhang, F. (2023) · Nutrients · doi:10.3390/nu15153340 · Cited by 18
Tian, Y., & Zhang, D. (2022) · Gastroenterology Research and Practice · doi:10.1155/2022/2939921 · Cited by 17
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Xiang, B., Hu, J. X., Zhang, M., & Zhi, M. (2023) · Gastroenterology report · doi:10.1093/gastro/goae076 · Cited by 19
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Yang, Z., Yu, Y., Chen, X.-F., Yang, S.-L., Tang, X., & Xiang, Z.-G. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.803686 · Cited by 16
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Bhosle, A., Bae, S., Zhang, Y., Chun, E., Ávila-Pacheco, J., Geistlinger, L., Pishchany, G., Glickman, J. N., Michaud, M., Waldron, L., et al. (2024) · Molecular Systems Biology · doi:10.1038/s44320-024-00027-8 · Cited by 16
Calzadilla, N., Qazi, A., Sharma, A., Mongan, K., Comiskey, S., Manne, J., Youkhana, A. G., Khanna, S., Saksena, S., Dudeja, P. K., et al. (2023) · Metabolites · doi:10.3390/metabo13070873 · Cited by 15
Kong, L., Chen, S.-Y., Huang, S., Zheng, A.-Z., Gao, S., Ye, J., & Hua, C.-Y. (2024) · Inflammation Research · doi:10.1007/s00011-024-01854-z · Cited by 14
Metabolomics facilitate the personalized management in inflammatory bowel disease
Chen, R., Zheng, J., Li, L., Li, C., Chao, K., Zeng, Z., Chen, M., & Zhang, S. (2021) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848211064489 · Cited by 14
Zakerska‐Banaszak, O., Żuraszek-Szymańska, J., Eder, P., Ladziak, K., Słomski, R., & Skrzypczak-Zielińska, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179589 · Cited by 17
Song, X., Wen, H., Zuo, L., Geng, Z., Nian, J., Wang, L., Jiang, Y.-F., Tao, J., Zhu, Z., Wu, X., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17077 · Cited by 13
Zhang, B., Ren, D.-Y., Yang, C., Zhao, Y., Zhang, X.-N., Tian, X., & Yang, X.-B. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c04024 · Cited by 12
Kim, J. E., Suh, D. H., Park, Y. J., Oh, C. H., Oh, S. J., Kang, H., Ji, Y., Kim, Y. J., Kim, W., Jung, E. S., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-90160-7 · Cited by 12
Baldi, S., Sarikaya, D., Lotti, S., Cuffaro, F., Fink, D., Colombini, B., Sofi, F., & Amedei, A. (2025) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2025.05.012 · Cited by 13
Wu, Q., Wu, X., Wang, M., Liu, K., Li, Y., Ruan, X., Lin, Q., Meng, L., Sun, Z., Zhu, L., et al. (2023) · Drug Design Development and Therapy · doi:10.2147/dddt.s399290 · Cited by 12
Advances and applications of gut organoids: modeling intestinal diseases and therapeutic development
Xu, X., Zhang, Y., Huang, G., Perekatt, A. O., Wang, Y., & Chen, L. (2025) · Life Medicine · doi:10.1093/lifemedi/lnaf012 · Cited by 16
Lopes, M. A., Oliveira, E. C. S., Quaglio, A. E. V., Santos, A., Imbrizi, M. R., Mendes, L. E. R., Beraldo, R. F., Baima, J. P., Spiller, A. L., Magro, D. O., et al. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i9.109035 · Cited by 11
Alaba, T., Holman, J. M., Ishaq, S. L., & Li, Y. (2024) · Current Developments in Nutrition · doi:10.1016/j.cdnut.2024.102160 · Cited by 15
Park, Y., Ahn, J. B., Kim, D. H., Park, I. S., Son, M., Kim, J. H., Woo, H. J., Kim, S. W., & Cheon, J. H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126697 · Cited by 14
Zhang, B., Magnaye, K. M., Stryker, E., Anderson, J. M., Porsche, C. E., Hertz, S., McCauley, K. E., Smith, B. J., Zydek, M., Pollard, K. S., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-62463-8 · Cited by 11
Zakerska‐Banaszak, O., Ladziak, K., Kruszka, D., Maciejewski, K., Wolko, Ł., Krela‐Kaźmierczak, I., Zawada, A. E., Vestergaard, M. V., Dobrowolska, A., & Skrzypczak-Zielińska, M. (2025) · Journal of Gastroenterology · doi:10.1007/s00535-025-02280-6 · Cited by 11
Tien, N. T. N., Choi, E. J., Thu, N. Q., Yu, S. J., Nguyen, D. N., Kim, D. H., Long, N. P., & Lee, H. S. (2024) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2024.116652 · Cited by 12
Metabolomics window into the diagnosis and treatment of inflammatory bowel disease in recent 5 years
Wang, J., Sun, Q., Gao, Y., Xiang, H., Zhang, C., Ding, P., Wu, T., & Ji, G. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109472 · Cited by 10
Zhou, Y.-W., Ren, Y., Lu, M., Xu, L., Cheng, W.-X., Zhang, M., Ding, L.-P., Chen, D., Gao, J., Du, J., et al. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i1.34 · Cited by 10
Baskaran, K., Moshkovich, M., Hart, L., Shah, N., Chowdhury, F., Shanmuganathan, M., Britz‐McKibbin, P., & Pai, N. (2024) · Biomarkers · doi:10.1080/1354750x.2024.2438734 · Cited by 8
Inflammatory Bowel Disease Therapy: Beyond the Immunome
Fiocchi, C., & Iliopoulos, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.864762 · Cited by 7
Gorreja, F., Bendix, M., Rush, S. T. A., Maasfeh, L., Savolainen, O. I., Dige, A. K., Agnholt, J. S., Öhman, L., & Magnusson, M. K. (2023) · Cells · doi:10.3390/cells13010060 · Cited by 7
Li, Z., Chen, C., Yu, W., Xu, L., Jia, H., Wang, C., Pei, N., Liu, Z., Luo, D., Wang, J., et al. (2023) · Nutrients · doi:10.3390/nu15112425 · Cited by 9
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Xu, M., Lin, C., Wang, C.-H., & Wang, S. (2024) · BioFactors · doi:10.1002/biof.2132 · Cited by 6
Haskey, N., Ye, J., Josephson, J. K., Raman, M., Ghosh, S., & Gibson, D. L. (2024) · Gastro Hep Advances · doi:10.1016/j.gastha.2024.100606 · Cited by 8
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Monma, T., Iwamoto, J., Ueda, H., Tamamushi, M., Kakizaki, F., Konishi, N., Yara, S., Miyazaki, T., Hirayama, T. T., Ikegami, T., et al. (2022) · World Journal of Clinical Cases · doi:10.12998/wjcc.v10.i34.12484 · Cited by 5
Integrated Metabolomics and Proteomics of Symptomatic and Early Presymptomatic States of Colitis
Shimshoni, E., Ghini, V., Solomonov, I., Luchinat, C., Sagi, I., & Turano, P. (2024) · Journal of Proteome Research · doi:10.1021/acs.jproteome.3c00860 · Cited by 7
Wark, G., Kaakoush, N. O., Samocha‐Bonet, D., Ghaly, S., & Danta, M. (2024) · Nutrients · doi:10.3390/nu16193233 · Cited by 5
Tan, T., VINCENT, M., Jain, U., Deepak, P., SPARC I. B. D. Investigators, Shukla, R., Dassopoulos, T., Korzenik, J., Snapper, S. B., Kudara, S., et al. (2026) · Digestive Diseases and Sciences · doi:10.1007/s10620-026-09779-9 · Cited by 4
Metabolomics and Risk of Dementia: A Systematic Review of Prospective Studies
Flores, A. C., Zhang, X., Kris‐Etherton, P. M., Sliwinski, M. J., Shearer, G. C., Gao, X., & Na, M. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2024.01.012 · Cited by 7
Zhu, Y., Xu, W., Liu, Z., Li, B., Wu, Y., Hua, Z., Wang, Y., Wang, X., Du, P., & Yang, H. (2023) · Asian Journal of Surgery · doi:10.1016/j.asjsur.2023.05.137 · Cited by 4
Are We Ready to Reclassify Crohn’s Disease Using Molecular Classification?
Kamal, S., Parkash, N., Beattie, W., Christensen, B., & Segal, J. P. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12185786 · Cited by 5
A comprehensive metabolite fingerprint of fibrostenosis in patients with Crohn’s disease
Bos, S., Lobatón, T., Vos, M. D., Welden, S. V., Plekhova, V., Paepe, E. D., Vanhaecke, L., & Laukens, D. (2023) · Scientific Reports · doi:10.1038/s41598-023-50461-1 · Cited by 4
Lucarini, E., Schettino, A., Marigliano, N., Ciampi, C., Smimmo, M., Romano, F., Paolillo, A., Izzo, L., Begum, J., Mansour, A. A., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107773 · Cited by 3
Yang, X., Dai, J., Yang, Q., Wei, H., Song, H., Liu, L., Huang, Y., Wang, L., Chen, P., Chen, X., et al. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106930 · Cited by 3
Rudbaek, J. J., Koziol, A., Fracchia, A., Ernst, M., Jess, T., Ottosson, F. A., Sazonovs, A., Kjær, M. W., Borbye‐Lorenzen, N., & Skogstrand, K. (2025) · Gastroenterology · doi:10.1053/j.gastro.2025.10.030 · Cited by 3
Kawaguchi, S., Chinda, D., Ota, S., Tonouchi, A., Maeda, H., Miura, K., Soma, G., Hiraga, H., Ueno, K., Niioka, T., et al. (2024) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.24-194 · Cited by 3
Metabolomic profiles as a new understanding of disease processes
Zolnikova, O. Y., Reshetova, M. S., Ivanova, M., & Ivashkin, V. T. (2022) · Russian Journal of Gastroenterology Hepatology Coloproctology · doi:10.22416/1382-4376-2022-32-1-46-52 · Cited by 4
Kim, S., Shin, S. Y., Park, S. J., Im, J. P., Kim, H. J., Lee, K., Kim, J. W., Jung, S.-A., Lee, J., Kang, S., et al. (2023) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848231168199 · Cited by 3
Metabolomic Applications in Gut Microbiota-Host Interactions in Human Diseases
Li, Y., & Han, S. (2024) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2023.12.008 · Cited by 4
Liu, Y., Sha, S., Ran, Q., Shi, H., Ma, J., Qin, B., Li, Y., Wang, N., Liu, X., Wang, J., et al. (2025) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izae299 · Cited by 3
Li, P., Chao, K., Hu, Z., Qin, L., Yang, T., Mao, J., Zhu, X., Hu, P., Wang, X., Gao, X., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1138506 · Cited by 2
Deng, L., Tian, L., Su, D., Xie, J., Qian, Y., Li, Y., Zhang, S., Wang, S., & Liu, Z. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178346 · Cited by 2
Rynikova, M., Bojcukova, V., & Demečková, V. (2026) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848261437918 · Cited by 3
Sharkiya, S. H., Namni, R., Wattad, O., & Baker, F. A. (2026) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848261441018 · Cited by 2
Evolution of a Pathogenic Microbiome
Wong, P. Y., Yip, C., Lemberg, D. A., Day, A. S., & Leach, S. T. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12227184 · Cited by 3
Metabolite profiling in assessing ulcerative colitis activity: A systematic review
Cui, D., Han, X., Jin, J., Wang, Y., Chen, Z., Yang, G., & Jiang, M. (2025) · Human Nutrition & Metabolism · doi:10.1016/j.hnm.2025.200298 · Cited by 2
Zhu, J.-W., Wang, H., Aisikaer, M., Zhou, W., Yang, T., & Aximujiang, K. (2025) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-025-3824-y · Cited by 2
Metadata
- Authors
- Gallagher, K., Catesson, A., Griffin, J. L., Holmes, E., & Williams, H. R. T.
- Affiliations
- Imperial College London (GB)
- Murdoch University (AU)
- Imperial College Healthcare NHS Trust (GB)
- Corresponding author
- Gallagher, Kate
- Venue
- Journal of Crohn's and Colitis
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-11-11
- Volume
- 15
- Issue
- 5
- Pages
- 813-826
- ISSN
- 1873-9946 (ISSN-L)
- 1876-4479
- OpenAlex
- W3102377839
- Cited by
- 133
- References
- 155
- Citations by year
- 2026: 18 · 2025: 27 · 2024: 29 · 2023: 27 · 2022: 20 · 2021: 12
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Crohn s and Colitis (publishedVersion)
- PubMed (publishedVersion)
- Murdoch University Research Portal (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- National Institute for Health Research Imperial Biomedical Research Centre
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Keywords
- inflammatory bowel disease, Crohn's disease
- MeSH terms
- Gastrointestinal Microbiome, Humans, Inflammatory Bowel Diseases, Metabolomics, Dysbiosis
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