Holmes, Elaine

Host-gut microbiota metabolic interactions

Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science

Gut microbiota and healthAnimal Nutrition and Physiology

Cited by 4,760

OPLS discriminant analysis: combining the strengths of PLS-DA and SIMCA classification

Bylesjö, M., Rantalainen, M., Cloarec, O., Nicholson, J. K., Holmes, E., & Trygg, J. (2006) · Journal of Chemometrics

Spectroscopy and Chemometric AnalysesStatistical Methods and Applications

Cited by 1,475

Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor

Smith, M. I., Yatsunenko, T., Manary, M. J., Trehan, I., Mkakosya, R., Cheng, J., Kau, A. L., Rich, S. S., Concannon, P., Mychaleckyj, J. C., et al. (2013) · Science

Gut microbiota and healthChild Nutrition and Water Access

Cited by 1,173

Symbiotic gut microbes modulate human metabolic phenotypes

Li, M., Wang, B., Zhang, M., Rantalainen, M., Wang, S., Zhou, H., Zhang, Y., Shen, J., Pang, X., Zhang, M., et al. (2008) · Proceedings of the National Academy of Sciences

Gut microbiota and healthMetabolomics and Mass Spectrometry Studies

Cited by 1,144

SARS-CoV-2 evolution during treatment of chronic infection

Kemp, S. A., Collier, D. A., Datir, R. P., Ferreira, I. A. T. M., Gayed, S., Jahun, A., Hosmillo, M., Rees-Spear, C., Mlcochova, P., Lumb, I. U., et al. (2021) · Nature

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 1,097

Human metabolic phenotype diversity and its association with diet and blood pressure

Holmes, E., Loo, R. L., Stamler, J., Bictash, M., Yap, I. K. S., Chan, Q., Ebbels, T., De Iorio, M., Brown, I. J., Veselkov, K. A., et al. (2008) · Nature

Metabolomics and Mass Spectrometry StudiesNutrition, Genetics, and Disease

Cited by 1,054

Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice

Dumas, M.-E., Barton, R. H., Toye, A., Cloarec, O., Blancher, C., Rothwell, A., Fearnside, J., Tatoud, R., Blanc, V., Lindon, J. C., et al. (2006) · Proceedings of the National Academy of Sciences

Gut microbiota and healthDiet, Metabolism, and Disease

Cited by 1,042

Gut microorganisms, mammalian metabolism and personalized health care

Nicholson, J. K., Holmes, E., & Wilson, I. D. (2005) · Nature Reviews Microbiology

Gut microbiota and healthPharmacogenetics and Drug Metabolism

Cited by 945

Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

Collier, D. A., Ferreira, I. A. T. M., Kotagiri, P., Datir, R. P., Lim, E. Y., Touizer, E., Meng, B., Abdullahi, A., The CITIID-NIHR BioResource COVID-19 Collaboration, Principal Investigators, et al. (2021) · Nature

SARS-CoV-2 and COVID-19 ResearchImmune responses and vaccinations

Cited by 751

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Collier, D. A., De Marco, A., Ferreira, I. A. T. M., Meng, B., Datir, R. P., Walls, A. C., Kemp, S. A., Bassi, J., Pinto, D., Silacci-Fregni, C., et al. (2021) · Nature

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 728

Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

Swann, J. R., Want, E. J., Geier, F. M., Spagou, K., Wilson, I. D., Sidaway, J. E., Nicholson, J. K., & Holmes, E. (2011) · Proceedings of the National Academy of Sciences

Gut microbiota and healthDrug Transport and Resistance Mechanisms

Cited by 726

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

Hoyles, L., Fernández-Real, J.-M., Federici, M., Serino, M., Abbott, J., Charpentier, J., Heymes, C., Luque, J. L., Anthony, E., Barton, R. H., et al. (2018) · Nature Medicine

Gut microbiota and healthLiver Disease Diagnosis and Treatment

Cited by 720

The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level

Barton, W., Penney, N. C., Cronin, O., Garcia-Perez, I., Molloy, M. G., Holmes, E., Shanahan, F., Cotter, P. D., & O'Sullivan, O. (2018) · Gut

Gut microbiota and healthProbiotics and Fermented Foods

Cited by 647

The gut microbiota influences skeletal muscle mass and function in mice

Lahiri, S., Kim, H., Garcia-Perez, I., Reza, M. M., Martin, K. A., Kundu, P., Cox, L. M., Selkrig, J., Posma, J. M., Zhang, H., et al. (2019) · Science Translational Medicine

Gut microbiota and healthMuscle Physiology and Disorders

Cited by 580

Understanding the role of gut microbiome–host metabolic signal disruption in health and disease

Holmes, E., Li, J. V., Athanasiou, T., Ashrafian, H., & Nicholson, J. K. (2011) · Trends in Microbiology

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 541

Precision High-Throughput Proton NMR Spectroscopy of Human Urine, Serum, and Plasma for Large-Scale Metabolic Phenotyping

Dona, A. C., Jiménez, B., Schäfer, H., Humpfer, E., Spraul, M., Lewis, M. R., Pearce, J. T. M., Holmes, E., Lindon, J. C., & Nicholson, J. K. (2014) · Analytical Chemistry

Metabolomics and Mass Spectrometry StudiesAdvanced NMR Techniques and Applications

Cited by 540

Cervical intraepithelial neoplasia disease progression is associated with increased vaginal microbiome diversity

Mitra, A., MacIntyre, D. A., Lee, Y. S., Smith, A., Marchesi, J. R., Lehne, B., Bhatia, R., Lyons, D., Paraskevaidis, E., Li, J. V., et al. (2015) · Scientific Reports

Reproductive tract infections researchCervical Cancer and HPV Research

Cited by 498

Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk

Holmes, E., Li, J. V., Marchesi, J. R., & Nicholson, J. K. (2012) · Cell Metabolism

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 490

Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: A randomised cross-over trial

Chambers, E. S., Byrne, C. S., Morrison, D. J., Murphy, K. G., Preston, T., Tedford, C., Garcia-Perez, I., Fountana, S., Serrano-Contreras, J. I., Holmes, E., et al. (2019) · Gut

Microbial Metabolites in Food BiotechnologyGut microbiota and health

Cited by 443

Probiotic modulation of symbiotic gut microbial–host metabolic interactions in a humanized microbiome mouse model

Martin, F. J., Wang, Y., Sprenger, N., Yap, I. K. S., Lundstedt, T., Lek, P., Rezzi, S., Ramadan, Z., van Bladeren, P., Fay, L. B., et al. (2008) · Molecular Systems Biology

Gut microbiota and healthProbiotics and Fermented Foods

Cited by 421

Colonization-induced host-gut microbial metabolic interaction

Claus, S. P., Ellero, S. L., Berger, B., Krause, L., Bruttin, A., Molina, J., Paris, A., Want, E. J., de Waziers, I., Cloarec, O., et al. (2011) · mBio

Gut microbiota and healthPharmacogenetics and Drug Metabolism

Cited by 414

Susceptibility of Human Metabolic Phenotypes to Dietary Modulation

Stella, C., Beckwith-Hall, B., Cloarec, O., Holmes, E., Lindon, J. C., Powell, J., van der Ouderaa, F., Bingham, S., Cross, A. J., & Nicholson, J. K. (2006) · Journal of Proteome Research

Metabolomics and Mass Spectrometry StudiesNutrition, Genetics, and Disease

Cited by 376

The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk

Kindinger, L. M., Bennett, P. R., Lee, Y. S., Marchesi, J. R., Smith, A., Cacciatore, S., Holmes, E., Nicholson, J. K., Teoh, T. G., & MacIntyre, D. A. (2017) · Microbiome

Preterm Birth and ChorioamnionitisReproductive tract infections research

Cited by 372

Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes

Claus, S. P., Tsang, T. M., Wang, Y., Cloarec, O., Skordi, E., Martin, F., Rezzi, S., Ross, A., Kochhar, S., Holmes, E., et al. (2008) · Molecular Systems Biology

Gut microbiota and healthMetabolomics and Mass Spectrometry Studies

Cited by 334