The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry
Abstract
Aims: The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry. Methods and results: 1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI), and clinical traits was analysed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene. The prevalence of HT, DM, and obesity (Ob) was 37, 10, and 21%, respectively. HT, DM, and Ob were associated with older age (P<0.001), less family history of HCM (HT and DM P<0.001), higher New York Heart Association (NYHA) class (P<0.001), atrial fibrillation (HT and DM P<0.001; Ob p = 0.03) and LV (left ventricular) diastolic dysfunction (HT and Ob P<0.001; DM P = 0.003). Stroke was more frequent in HT (P<0.001) and mutation-positive patients with DM (P = 0.02). HT and Ob were associated with higher provocable LV outflow tract gradients (HT P<0.001, Ob P = 0.036). LV hypertrophy was more severe in Ob (P = 0.018). HT and Ob were independently associated with NYHA class (OR 1.419, P = 0.017 and OR 1.584, P = 0.004, respectively). Other associations, including a higher proportion of females in HT and of systolic dysfunction in HT and Ob, were observed only in mutation-positive patients. Conclusion: Common CVRF are associated with a more severe HCM phenotype, suggesting a proactive management of CVRF should be promoted. An interaction between genotype and CVRF was observed for some traits.
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Individuals with HCM often have concomitant arterial hypertension, with an incidence rate of 37%.
“Moreover, individuals with HCM often have concomitant AH, a phenomenon described in a previous study with an incidence rate of 37% (21).”
From Discontinuation of afterload-reducing drugs decreases left ventricular outflow tract obstruction in hypertrophic obstructive cardiomyopathy (2024) · cites this paper as [21]
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Self-citation2016 European Guidelines on cardiovascular disease prevention in clinical practice
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Derda, A. A., Abelmann, M., Sonnenschein, K., Sieweke, J.-T., Bavendiek, U., Bauersachs, J., Thum, T., & Berliner, D. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1403422 · Cited by 6
Metadata
- Authors
- Lopes, L. R., Losi, M.-A., Sheikh, N., Laroche, C., Charron, P., Gimeno, J., Kaski, J. P., Maggioni, A. P., Tavazzi, L., Arbustini, E., Brito, D., Celutkiene, J., Hagege, A., Linhart, A., Mogensen, J., Garcia-Pinilla, J. M., Ripoll-Vera, T., Seggewiss, H., Villacorta, E., Caforio, A., Elliott, P. M., The Cardiomyopathy Registry Investigators Group, Gale, C. P., Beleslin, B., Budaj, A., Chioncel, O., Dagres, N., Danchin, N., Erlinge, D., Emberson, J., Glikson, M., Gray, A., Kayikcioglu, M., Maggioni, A., Nagy, K. V., Nedoshivin, A., Petronio, A.-S., Hesselink, J. R., Wallentin, L., Zeymer, U., Caforio, A., Blanes, J. R. G., Charron, P., Elliott, P., Kaski, J. P., Maggioni, A. P., Tavazzi, L., Tendera, M., Komissarova, S., Chakova, N., Niyazova, S., Linhart, A., Kuchynka, P., Palecek, T., Podzimkova, J., Fikrle, M., Nemecek, E., Bundgaard, H., Tfelt-Hansen, J., Theilade, J., Thune, J. J., Axelsson, A., Mogensen, J., Henriksen, F., Hey, T., Nielsen, S. K., Videbaek, L., Andreasen, S., Arnsted, H., Saad, A., Ali, M., Lommi, J., Helio, T., Nieminen, M. S., Dubourg, O., Mansencal, N., Arslan, M., Tsieu, V. S., Damy, T., Guellich, A., Guendouz, S., Tissot, C. M., Lamine, A., Rappeneau, S., Hagege, A., Desnos, M., Bachet, A., Hamzaoui, M., Charron, P., Isnard, R., Legrand, L., Maupain, C., Gandjbakhch, E., Kerneis, M., Pruny, J.-F., Bauer, A., Pfeiffer, B., Felix, S. B., Dorr, M., Kaczmarek, S., Lehnert, K., Pedersen, A.-L., Beug, D., Bruder, M., Böhm, M., Kindermann, I., Linicus, Y., Werner, C., Neurath, B., Schild-Ungerbuehler, M., Seggewiss, H., Pfeiffer, B., Neugebauer, A., McKeown, P., Muir, A., McOsker, J., Jardine, T., Divine, G., Elliott, P., Lorenzini, M., Watkinson, O., Wicks, E., Iqbal, H., Mohiddin, S., O'Mahony, C., Sekri, N., Carr-White, G., Bueser, T., Rajani, R., Clack, L., Damm, J., Jones, S., Sanchez-Vidal, R., Smith, M., Walters, T., Wilson, K., Rosmini, S., Anastasakis, A., Ritsatos, K., Vlagkouli, V, Forster, T., Sepp, R., Borbas, J., Nagy, V, Tringer, A., Kakonyi, K., Szabo, L. A., Maleki, M., Bezanjani, F. N., Amin, A., Naderi, N., Parsaee, M., Taghavi, S., Ghadrdoost, B., Jafari, S., Khoshavi, M., Rapezzi, C., Biagini, E., Corsini, A., Gagliardi, C., Graziosi, M., Longhi, S., Milandri, A., Ragni, L., Palmieri, S., Olivotto, I., Arretini, A., Castelli, G., Cecchi, F., Fornaro, A., Tomberli, B., Spirito, P., Devoto, E., Bella, P. D., Maccabelli, G., Sala, S., Guarracini, F., Peretto, G., Russo, M. G., Calabro, R., Pacileo, G., Limongelli, G., Masarone, D., Pazzanese, V, Rea, A., Rubino, M., Tramonte, S., Valente, F., Caiazza, M., Cirillo, A., Del Giorno, G., Esposito, A., Gravino, R., Marrazzo, T., Trimarco, B., Losi, M.-A., Di Nardo, C., Giamundo, A., Musella, F., Pacelli, F., Scatteia, A., Canciello, G., Caforio, A., Iliceto, S., Calore, C., Leoni, L., Marra, M. P., Rigato, I., Tarantini, G., Schiavo, A., Testolina, M., Arbustini, E., Di Toro, A., Giuliani, L. P., Serio, A., Fedele, F., Frustaci, A., Alfarano, M., Chimenti, C., Drago, F., Baban, A., Calò, L., Lanzillo, C., Martino, A., Uguccioni, M., Zachara, E., Halasz, G., Re, F., Sinagra, G., Carriere, C., Merlo, M., Ramani, F., Kavoliuniene, A., Krivickiene, A., Tamuleviciute-Prasciene, E., Viezelis, M., Celutkiene, J., Balkeviciene, L., Laukyte, M., Paleviciute, E., Pinto, Y., Wilde, A., Asselbergs, F. W., Sammani, A., Van Der Heijden, J., Van Laake, L., De Jonge, N., Hassink, R., Kirkels, J. H., Ajuluchukwu, J., Olusegun-Joseph, A., Ekure, E., Mizia-Stec, K., Tendera, M., Czekaj, A., Sikora-Puz, A., Skoczynska, A., Wybraniec, M., Rubis, P., Dziewiecka, E., Wisniowska-Smialek, S., Bilinska, Z., Chmielewski, P., Foss-Nieradko, B., Michalak, E., Stepien-Wojno, M., Mazek, B., Lopes, L. R., Almeida, A. R., Cruz, I., Gomes, A. C., Pereira, A. R., Brito, D., Madeira, H., Francisco, A. R., Menezes, M., Moldovan, O., Guimaraes, T. O., Silva, D., Ginghina, C., Jurcut, R., Mursa, A., Popescu, B. A., Apetrei, E., Militaru, S., Coman, I. M., Frigy, A., Fogarasi, Z., Kocsis, I., Szabo, I. A., Fehervari, L., Nikitin, I., Resnik, E., Komissarova, M., Lazarev, V, Shebzukhova, M., Ustyuzhanin, D., Blagova, O., Alieva, I., Kulikova, V, Lutokhina, Y., Pavlenko, E., Varionchik, N., Ristic, A. D., Seferovic, P. M., Veljic, I., Zivkovic, I., Milinkovic, I., Pavlovic, A., Radovanovic, G., Simeunovic, D., Zdravkovic, M., Aleksic, M., Djokic, J., Hinic, S., Klasnja, S., Mircetic, K., Monserrat, L., Fernandez, X., Garcia-Giustiniani, D., Larrañaga, J. M., Ortiz-Genga, M., Barriales-Villa, R., Martinez-Veira, C., Veira, E., Cequier, A., Salazar-Mendiguchia, J., Manito, N., Gonzalez, J., Fernández-Avilés, F., Medrano, C., Yotti, R., Cuenca, S., Espinosa, M. A., Mendez, I., Zatarain, E., Alvarez, R., Pavia, P. G., Briceno, A., Cobo-Marcos, M., Dominguez, F., Galvan, E. D. T., Pinilla, J. M. G., Abdeselam-Mohamed, N., Lopez-Garrido, M. A., Hidalgo, L. M., Ortega-Jimenez, M. V., Mezcua, A. R., Guijarro-Contreras, A., Gomez-Garcia, D., Robles-Mezcua, M., Blanes, J. R. G., Castro, F. J., Esparza, C. M., Molina, M. S., García, M. S., Cuenca, D. L., de Mallorca, P., Ripoll-Vera, T., Alvarez, J., Nunez, J., Gomez, Y., Fernandez, P. L. S., Villacorta, E., Avila, C., Bravo, L., Diaz-Pelaez, E., Gallego-Delgado, M., Garcia-Cuenllas, L., Plata, B., Lopez-Haldon, J. E., Pena Pena, M. L., Perez, E. M. C., Zorio, E., Arnau, M. A., Sanz, J., & Marques-Sule, E.
- Affiliations
- Serviço de Cardiologia, Hospital Garcia de Orta , Av. Torrado da Silva, Almada 2805-267, Portugal
- Department of Advanced Biomedical Sciences, University Federico II , Corso Umberto I, 40, Naples 80138, Italy
- Department of Cardiology and Division of Cardiovascular Sciences, Guy's and St. Thomas’ Hospitals and King's College London , Strand, London WC2R 2LS, UK
- EORP, European Society of Cardiology , Sophia-Antipolis, France
- Hospital Clínico Universitario Virgen de la Arrixaca , Ctra. Madrid-Cartagena, Murcia 30120 El, Spain
- Institute of Cardiovascular Science, University College London , Gower St, London WC1E 6BT, UK
- Centre for Inherited Cardiovascular Diseases, Fondazione IRCCS Policlinico San Matteo , Viale Camillo Golgi, Pavia 27100, Italy
- Serviço de Cardiologia, Centro Hospitalar Universitário Lisboa Norte , Lisbon 1169-050, Portugal
- Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University , Universiteto g. 3, Vilnius 01513, Lithuania
- Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Département de Cardiologie, Paris, France & Université Paris Descartes, Sorbonne Paris Cité , Paris 75006, France
- 2nd Department of Internal Cardiovascular Medicine, General University Hospital and First Medical Faculty, Charles University , Opletalova 38, Prague 110 00, Czech Republic
- Department of Cardiology, Odense University Hospital , J. B. Winsløws Vej 4, Odense 5000, Denmark
- Unidad de Insuficiencia Cardiaca y Cardiopatías Familiares. Servicio de Cardiología. Hospital Universitario Virgen de la Victoria. IBIMA. Málaga and Ciber-Cardiovascular. Instituto de Salud Carlos III. Madrid , Spain
- Inherited Cardiovascular Disease Unit Son Llatzer University Hospital & IdISBa , Palma de Mallorca, Spain
- Universitätsklinikum Würzburg, Deutsches Zentrum für Herzinsuffizienz (DZHI) , Comprehensive Heart Failure Center (CHFC), Am Schwarzenberg 15, Haus 15A, 97078 Wurzburg, Germany
- Member of National Centers of expertise for familial cardiopathies (CSUR), Cardiology Department, University Hospital of Salamanca. Institute of Biomedical Research of Salamanca (IBSAL) , CIBERCV, Salamanca, Spain
- Venue
- European Heart Journal - Quality of Care and Clinical Outcomes
- Publisher
- Oxford University Press (OUP)
- Published
- 2022-02-09
- Volume
- 9
- Issue
- 1
- Pages
- 42-53
- ISSN
- 2058-5225
- 2058-1742
- PMC
- PMC9745665
- Cited by
- 46
- References
- 2
- Language
- en
- Funders
- Abbott Vascular (2011-2021)
- Amgen Foundation (2009-2018)
- AstraZeneca (2014-2021)
- Bayer AG (2009-2018)
- Boehringer Ingelheim (2009-2019)
- Boston Scientific (2009-2012)
- Bristol Myers Squibb
- Pfizer (2011-2019)
- Daiichi Sankyo Europe GmbH (2011-2020)
- Alliance Daiichi Sankyo Europe GmbH
- Eli Lilly and Company (2014-2017)
- Edwards (2016-2019)
- Gedeon Richter (2014-2016)
- Menarini Int. Op. (2009-2012)
- MSD-Merck & Co. (2011-2014)
- Novartis Pharma (2014-2020)
- ResMed Foundation (2014-2016)
- Sanofi (2009-2011)
- Servier (2009-2021)
- Vifor Pharma (2019-2022)
- Medical Research Council
- British Heart Foundation
- GOSH
- NIHR
- BRC
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