The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult mice
Open accessAbstract
To dissect the effects of corticosteroids mediated by the mineralocorticoid (MR) and the glucocorticoid receptor (GR) in the central nervous system, we compared MR −/− mice, whose salt loss syndrome was corrected by exogenous NaCl administration, with GR −/− mice having a brain‐specific disruption of the GR gene generated by the Cre/loxP‐recombination system. Neuropathological analyses revealed a decreased density of granule cells in the hippocampus of adult MR −/− mice but not in mice with disruption of GR. Furthermore, adult MR −/− mice exhibited a significant reduction of granule cell neurogenesis to 65% of control levels, possibly mediated by GR due to elevated corticosterone plasma levels. Neurogenesis was unaltered in adult mice with disruption of GR. Thus, we could attribute long‐term trophic effects of adrenal steroids on dentate granule cells to MR. These MR‐related alterations may participate in the pathogenesis of hippocampal changes observed in ageing, chronic stress and affective disorders.
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Cites
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087
Restoring production of hippocampal neurons in old age
Cameron, H. A., & McKay, R. D. G. (1999) · Nature Neuroscience · doi:10.1038/13197 · Cited by 710
Cited by
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621
Discovering Endophenotypes for Major Depression
Hasler, G., Drevets, W. C., Manji, H. K., & Charney, D. S. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300506 · Cited by 1,123
Mirescu, C., & Gould, E. (2006) · Hippocampus · doi:10.1002/hipo.20155 · Cited by 701
The AP-1 Transcription Factor c-Jun Is Required for Efficient Axonal Regeneration
Raivich, G., Bohatschek, M., Da Costa, C., Iwata, O., Galiano, M., Hristova, M., Nateri, A. S., Makwana, M., Riera-Sans, L., Wolfer, D. P., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.005 · Cited by 489
Self-citationCorticosteroid hormones in the central stress response: Quick-and-slow
de Kloet, E. R., Karst, H., & Joëls, M. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.10.002 · Cited by 391
Metadata
- Authors
- Gass, P., Kretz, O., Wolfer, D. P., Berger, S., Tronche, F., Reichardt, H. M., Kellendonk, C., Lipp, H., Schmid, W., & Schütz, G.
- Venue
- EMBO reports
- Published
- 2000-11
- Volume
- 1
- Issue
- 5
- Pages
- 447-451
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2040465695
- Cited by
- 158
- References
- 3
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Gass, P., Kretz, O., Wolfer, D. P., Berger, S., Tronche, F., Reichardt, H. M., Kellendonk, C., Lipp, H., Schmid, W., & Schütz, G. (2000). Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult mice. EMBO reports. https://doi.org/10.1093/embo-reports/kvd088
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