Restoring production of hippocampal neurons in old age
Abstract
The production of hippocampal granule neurons continues throughout adulthood but dramatically decreases in old age. Here we show that reducing corticosteroid levels in aged rats restored the rate of cell proliferation, resulting in increased numbers of new granule neurons. This result indicates that the neuronal precursor population in the dentate gyrus remains stable into old age, but that neurogenesis is normally slowed by high levels of corticosteroids. The findings further suggest that decreased neurogenesis may contribute to age-related memory deficits associated with high corticosteroids, and that these deficits may be reversible.
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Decelerated neurogenesis and hippocampal atrophy are associated with memory deficits in humans.
“Decelerated neurogenesis and hippocampal atrophy are associated with memory deficits in humans (Cameron and McKay, 1999).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Cameron and McKay, 1999
This age-associated increase in corticosterone was also reported in rats, and was associated with a decline in hippocampal neurogenesis.
“This age-associated increase in corticosterone was also reported in rats, and was associated with a decline in hippocampal neurogenesis (Cameron and McKay, 1999;Sapolsky, 1992).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Cameron and McKay, 1999
Corticosterone depletion via adrenalectomy rescued these neurogenesis deficits in aged rats to a level comparable to the young adults.
“Moreover, corticosterone depletion via adrenalectomy rescued these neurogenesis deficits in aged rats to a level comparable to the young adults (Cameron and McKay, 1999).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Cameron and McKay, 1999
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- Authors
- Cameron, H. A., & McKay, R. D. G.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Cameron, Heather A.
- ORCID
- Cameron, Heather A.
- Venue
- Nature Neuroscience
- Published
- 1999-10
- Volume
- 2
- Issue
- 10
- Pages
- 894-897
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1592665312
- Cited by
- 710
- References
- 38
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 16 · 2019: 18 · 2018: 11 · 2017: 26 · 2016: 23 · 2015: 22 · 2014: 28 · 2013: 31 · 2012: 24
- FWCI
- 6.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampal neurogenesis, adult neurogenesis, granule neurons, dentate gyrus, aging, corticosteroids, glucocorticoids, cell proliferation, age-related memory decline, neuronal precursors
- MeSH terms
- Adrenal Cortex Hormones, Adrenal Glands, Adrenalectomy, Aging, Animals, Bromodeoxyuridine, Cell Division, Cell Survival, DNA, Hippocampus, Neurons, Biomarkers, Rats, Sprague-Dawley, Rats
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