Cited by 391Stress Responses and CortisolMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Corticosteroid hormones in the central stress response: Quick-and-slow

de Kloet, E. Ronald, Karst, Henk, Joëls, Marian·2008·Frontiers in Neuroendocrinology

Abstract

Recent evidence shows that corticosteroid hormones exert rapid non-genomic effects on neurons in the hypothalamus and the hippocampal CA1 region. The latter depend on classical mineralocorticoid receptors which are accessible from the outside of the plasma membrane and display a 10-fold lower affinity for corticosterone than the nuclear version involved in neuroprotection. Consequently, this 'membrane' receptor could play an important role while corticosteroid levels are high, i.e. during the initial phase of the stress response. We propose that during this phase corticosterone promotes hippocampal excitability and amplifies the effect of other stress hormones. These permissive non-genomic effects may contribute to fast behavioral effects and encoding of stress-related information. The fast effects are complemented by slower glucocorticoid receptor-mediated effects which facilitate suppression of temporary raised excitability, recovery from the stressful experience and storage of information for future use.

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Crossref · 10.1016/j.yfrne.2007.10.002

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Authors
de Kloet, E. R., Karst, H., & Joëls, M.
Affiliations
University of Amsterdam (NL)
Venue
Frontiers in Neuroendocrinology
Publisher
Elsevier BV
Published
2008-05
Volume
29
Issue
2
Pages
268-272
ISSN
0091-3022 (ISSN-L)
OpenAlex
W2137942121
Cited by
391
References
43
Citations by year
2026: 6 · 2025: 9 · 2024: 7 · 2023: 11 · 2022: 17 · 2021: 16 · 2020: 21 · 2019: 14 · 2018: 25 · 2017: 17 · 2016: 27 · 2015: 23 · 2014: 38 · 2013: 22 · 2012: 31
FWCI
1.59
Type
journal article
Language
en
Open access
closed
Locations
  • Frontiers in Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • UvA-DARE (University of Amsterdam) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
corticosteroids, non-genomic steroid effects, glucocorticoid receptor, hypothalamus, hippocampal CA1, hippocampal excitability, stress response, corticosterone, neuroprotection
MeSH terms
Adrenal Cortex Hormones, Animals, Hippocampus, Humans, Hypothalamus, Neurons, Receptors, Glucocorticoid, Stress, Physiological, Time Factors, Genome, Receptors, Mineralocorticoid

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