The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The atypical protein kinase Cs: Functional specificity mediated by specific protein adapters
Open accessAbstract
Since its discovery more than 10 years ago, the atypical PKC (aPKC) subfamily has attracted great interest. A number of reports have shown that the kinases of this subfamily play critical roles in signaling pathways that control cell growth, differentiation and survival. Recently, several investigators have identified a number of aPKC‐interacting proteins whose characterization is helping to unravel the mechanisms of action and functions of these kinases. These interactors include p62, Par‐6, MEK5 and Par‐4. The details of how these adapters serve to link the aPKCs to different receptor signaling pathways and substrates in response to specific stimuli are crucial not only for developing an understanding of the roles and functions of the aPKCs themselves, but also for more generally establishing a view of how specificity in signal transduction is achieved.
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Cites
Protein kinase C and lipid signaling for sustained cellular responses
Nishizuka, Y. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.7.7737456 · Cited by 2,499
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
Joberty, G., Petersen, C., Gao, L., & Macara, I. G. (2000) · Nature Cell Biology · doi:10.1038/35019573 · Cited by 928 · cited 1×
“The localization of endogenous Par-6 has not been reported and is an important issue, as the ectopic expression of Par-6 disrupts tight junctions (Joberty et al., 2000); this finding seems to be inconsistent with its proposed role in maintaining cell polarity.”
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Cited by
Protein kinase C and other diacylglycerol effectors in cancer
Griner, E. M., & Kazanietz, M. G. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2110 · Cited by 978
NF-κB signaling pathways in mammalian and insect innate immunity
Silverman, N., & Maniatis, T. (2001) · Genes & Development · doi:10.1101/gad.909001 · Cited by 907
Seibenhener, M. L., Babu, J. R., Geetha, T., Wong, H. C., Krishna, N. R., & Wooten, M. W. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.18.8055-8068.2004 · Cited by 710
Berkes, J., Viswanathan, V. K., Savkovic, S. D., & Hecht, G. (2003) · Gut · doi:10.1136/gut.52.3.439 · Cited by 601
The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis
Duran, A., Linares, J. F., Galvez, A. S., Wikenheiser, K., Flores, J. M., Diaz-Meco, M. T., & Moscat, J. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.02.001 · Cited by 541
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Metadata
- Authors
- Moscat, J., & Diaz‐Meco, M. T.
- Venue
- EMBO reports
- Published
- 2000-11
- Volume
- 1
- Issue
- 5
- Pages
- 399-403
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2100246616
- Cited by
- 217
- References
- 2
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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