The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Dynamic behavior of transcription factors on a natural promoter in living cells
Open accessAbstract
Through the use of photobleaching techniques, we examined the dynamic interaction of three members of the transcrsiption apparatus with a target promoter in living cells. The glucocorticoid receptor (GR) interacting protein 1 (GRIP‐1) exhibits a half maximal time for fluorescent recovery (τ R ) of 5 s, reflecting the same rapid exchange as observed for GR. In contrast, the large subunit (RPB1) of RNA polymerase II (pol II) required 13 min for complete fluorescence recovery, consistent with its function as a processive enzyme. We also observe a complex induction profile for the kinetics of GR‐stimulated transcription. Our results indicate that GR and GRIP‐1 as components of the activating complex are in a dynamic equilibrium with the promoter, and must return to the template many times during the course of transcriptional activation.
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Citations
Cites
The glucocorticoid receptor: rapid exchange with regulatory sites in living cells
McNally, J. G., Müller, W. G., Walker, D., Wolford, R., & Hager, G. L. (2000) · Science · doi:10.1126/science.287.5456.1262 · Cited by 802 · cited 3×
“Added to this complexity is our recent observation that in the continued presence of ligand the glucocorticoid receptor (GR) exchanges rapidly with regulatory elements in living cells (McNally et al., 2000).”
BackgroundMethod
Cited by
In vivo dynamics of RNA polymerase II transcription
Darzacq, X., Shav-Tal, Y., de Turris, V., Brody, Y., Shenoy, S. M., Phair, R. D., & Singer, R. H. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1280 · Cited by 665
RNA polymerase II clustering through carboxy-terminal domain phase separation
Boehning, M., Dugast-Darzacq, C., Rankovic, M., Hansen, A. S., Yu, T., Marie-Nelly, H., McSwiggen, D. T., Kokic, G., Dailey, G. M., Cramer, P., et al. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-018-0112-y · Cited by 601
Glucocorticoid receptor control of transcription: precision and plasticity via allostery
Weikum, E. R., Knuesel, M. T., Ortlund, E. A., & Yamamoto, K. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.152 · Cited by 533
Dynamic regulation of transcriptional states by chromatin and transcription factors
Voss, T. C., & Hager, G. L. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3623 · Cited by 504
Self-citationDynamics of ACTH and Cortisol Secretion and Implications for Disease
Lightman, S. L., Birnie, M. T., & Conway-Campbell, B. L. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa002 · Cited by 439
Metadata
- Authors
- Becker, M., Baumann, C., John, S., Walker, D. A., Vigneron, M., McNally, J. G., & Hager, G. L.
- Venue
- EMBO reports
- Published
- 2002-12
- Volume
- 3
- Issue
- 12
- Pages
- 1188-1194
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2097371203
- Cited by
- 211
- References
- 1
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Becker, M., Baumann, C., John, S., Walker, D. A., Vigneron, M., McNally, J. G., & Hager, G. L. (2002). Dynamic behavior of transcription factors on a natural promoter in living cells. EMBO reports. https://doi.org/10.1093/embo-reports/kvf244
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