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Cited by 74

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Cellular uptake of saposin (SAP) precursor and lysosomal delivery by the low density lipoprotein receptor‐related protein (LRP)

Hiesberger, Thomas, Hüttler, Silke, Rohlmann, Astrid, Schneider, Wolfgang, Sandhoff, Konrad, Herz, Joachim·1998·The EMBO Journal
DOI 10.1093/emboj/17.16.4617
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Research works printed but not linked: 41

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  8. Herz J, Goldstein JL, Strickland DK, Ho YK and Brown MS (1991) 39‐kDa protein modulates binding of ligands to low density lipoprotein receptor‐related protein/α2‐macroglobulin receptor. J Biol Chem, 266, 21232–21238. · DOI · Paper page
  9. Herz J, Qiu SQ, Oesterle A, DeSilva HV, Shafi S and Havel RJ (1995) Initial hepatic removal of chylomicron remnants is unaffected but endocytosis is delayed in mice lacking the low density lipoprotein receptor. Proc Natl Acad Sci USA, 92, 4611–4615. · DOI
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  12. Hiraiwa M, Soeda S, Kishimoto Y and O'Brien JS (1992) Binding and transport of gangliosides by prosaposin. Proc Natl Acad Sci USA, 89, 11254–11258. · DOI
  13. Hiraiwa M, Taylor EM, Campana WM, Darin SJ and O'Brien JS (1997) Cell death prevention, mitogen‐activated protein kinase stimulation and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides. Proc Natl Acad Sci USA, 94, 4778–4781. · DOI
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  16. Kotani Y, Matsuda S, Wen TC, Sakanaka M, Tanaka J, Maeda N, Kondoh K, Ueno S and Sano A (1996) A hydrophilic peptide comprising 18 amino acid residues of the prosaposin sequence has neurotrophic activity in vitro and in vivo. J Neurochem, 66, 2197–2200. · DOI
  17. Kowal RC, Herz J, Goldstein JL, Esser V and Brown MS (1989) Low density lipoprotein receptor‐related protein mediates uptake of cholesteryl esters derived from apoprotein E‐enriched lipoproteins. Proc Natl Acad Sci USA, 86, 5810–5814. · DOI
  18. Kowal RC, Herz J, Mahley RW, Brown MS and Goldstein JL (1990) Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor‐related protein. J Biol Chem, 265, 10771–10779. · DOI · Paper page
  19. Krieger M and Herz J (1994) Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor‐related protein (LRP). Annu Rev Biochem, 63, 601–637. · DOI
  20. Lindstedt KA, Bujo H, Mahon MG, Nimpf J and Schneider WJ (1997) Germ cell‐somatic cell dichotomy of a low‐density lipoprotein receptor gene family member in testis. DNA Cell. Biol, 16, 35–43.
  21. Morgan DO, Edman JC, Standring DN, Fried VA, Smith MC, Roth RA and Rutter WJ (1987) Insulin‐like growth factor II receptor as a multifunctional binding protein [published erratum appears in Nature 1988 July, 20 (7):442]. Nature, 329, 301–307. · DOI
  22. O'Brien JS, Carson GS, Seo HC, Hiraiwa M and Kishimoto Y (1994) Identification of prosaposin as a neurotrophic factor. Proc Natl Acad Sci USA, 91, 9593–9596. · DOI
  23. Orth K, Madison EL, Gething M‐J, Sambrook JF and Herz J (1992) Complexes of t‐PA and its serpin inhibitor PAI‐1 are internalized via the LRP/a2‐macroglobulin receptor. Proc Natl Acad Sci USA, 89, 7422–7426. · DOI
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  31. Sandhoff K, Harzer K and Furst W (1995) Sphingolipid activator proteins. In Scriver,C.R. Beaudet,A.L., Sly,W.S. and Valle,D. (eds), The Metabolic and Molecular Basis of Inherited Disease McGraw‐Hill, New York, NY, pp. 2427–2441.
  32. Schmid B, Paton BC, Sandhoff K and Harzer K (1992) Metabolism of GM1 ganglioside in cultured skin fibroblasts: anomalies in gangliosidoses, sialidoses and sphingolipid activator protein (SAP, saposin) 1 and prosaposin deficient disorders. Hum Genet, 89, 513–518. · DOI
  33. Schnabel D, Schroder M and Sandhoff K (1991) Mutation in the sphingolipid activator protein 2 in a patient with a variant of Gaucher disease. FEBS Lett, 284, 57–59. · DOI
  34. Stahl PD and Schlesinger PH (1980) Receptor‐mediated pinocytosis of mannose/N‐acetylglucosamine‐terminated glycoproteins and lyso‐ somal enzymes by macrophages. Trends Biochem Sci, 5, l94–l96. · DOI
  35. Vaccaro AM, Tatti M, Ciaffoni F, Salvioli R, Barca A and Scerch C (1997) Effect of saposins A and C on the enzymatic hydrolysis of liposomal glucosylceramide. J Biol Chem, 272, 16862–16867. · DOI
  36. van Dongen JM, Willemsen R, Ginns EI, Sips HJ, Tager JM, Barranger JA and Reuser AJ (1985) The subcellular localization of soluble and membrane‐bound lysosomal enzymes in I‐cell fibroblasts: a comparative immunocytochemical study. Eur J Cell Biol, 39, 179–189.
  37. Vielhaber G, Hurwitz R and Sandhoff K (1996) Biosynthesis, processing and targeting of sphingolipid activator protein (SAP) precursor in cultured human fibroblasts. Mannose 6‐phosphate receptor‐independent endocytosis of SAP precursor. J Biol Chem, 271, 32438–32446. · DOI
  38. Weiler S, Kishimoto Y, O'Brien JS, Barranger JA and Tomich JM (1995) Identification of the binding and activating sites of the sphingolipid activator protein, saposin C, with glucocerebrosidase. Protein Sci, 4, 756–764. · DOI
  39. Willnow TE and Herz J (1994) Genetic deficiency in low density lipoprotein receptor‐related protein (LRP) confers cellular resistance to pseudomonas exotoxin A—evidence that LRP is required for uptake and degradation of multiple ligands. J Cell Sci, 107, 719–726. · DOI
  40. Zhang XL, Rafi MA, DeGala G and Wenger DA (1990) Insertion in the mRNA of a metachromatic leukodystrophy patient with sphingolipid activator protein‐1 deficiency. Proc Natl Acad Sci USA, 87, 1426–1430. · DOI
  41. Zhang XL, Rafi MA, DeGala G and Wenger DA (1991) The mechanism for a 33‐nucleotide insertion in mRNA causing sphingolipid activator protein (SAP‐1)‐deficient metachromatic leukodystrophy. Hum Genet, 87, 211–215. · DOI

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Metadata

Authors
Hiesberger, T., Hüttler, S., Rohlmann, A., Schneider, W., Sandhoff, K., & Herz, J.
Venue
The EMBO Journal
Publisher
Springer Science and Business Media LLC
Published
1998-08-17
Volume
17
Issue
16
Pages
4617-4625
ISSN
  • 0261-4189
  • 1460-2075
DOI
10.1093/emboj/17.16.4617
Cited by
74
References
2
Language
en
Licence

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