Promotion of Both Proliferation and Neuronal Differentiation in Pluripotent P19 Cells with Stable Overexpression of the Glutamine Transporter slc38a1

Ogura, Masato; Kakuda, Takami; Takarada, Takeshi; Nakamichi, Noritaka; Fukumori, Ryo; Kim, Yeong-Hun; Hinoi, Eiichi; Yoneda, Yukio

doi:10.1371/journal.pone.0048270

Promotion of Both Proliferation and Neuronal Differentiation in Pluripotent P19 Cells with Stable Overexpression of the Glutamine Transporter slc38a1

Background We previously demonstrated the functional expression in newborn rat neocortical astrocytes of glutamine transporter (GlnT = slc38a1) believed to predominate in neurons over astroglia in the brain. In order to evaluate the possible role of this transporter in neurogenesis, we attempted …