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Cathepsin D and its newly identified transport receptor SEZ6L2 can modulate neurite outgrowth

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Cathepsin D expression is decreased in Alzheimer's disease fibroblasts

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Autosomal Dominant Adult Neuronal Ceroid Lipofuscinosis: a Novel Form of NCL with Granular Osmiophilic Deposits without Palmitoyl Protein Thioesterase 1 Deficiency

Nijssen, P. C. G., Ceuterick, C., van Diggelen, O. P., Elleder, M., Martin, J., Teepen, J. L. J. M., Tyynelä, J., & Roos, R. A. C. (2003) · Brain Pathology · doi:10.1111/j.1750-3639.2003.tb00486.x · Cited by 60

Proteomic analysis of cathepsin B and L-deficient mouse brain lysosomes

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Cathepsin E Deficiency Induces a Novel Form of Lysosomal Storage Disorder Showing the Accumulation of Lysosomal Membrane Sialoglycoproteins and the Elevation of Lysosomal pH in Macrophages

Yanagawa, M., Tsukuba, T., Nishioku, T., Okamoto, Y., Okamoto, K., Takii, R., Terada, Y., Nakayama, K. I., Kadowaki, T., & Yamamoto, K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604143200 · Cited by 60

Cathepsin D is one of the major enzymes involved in intracellular degradation of AGE-modified proteins

Grimm, S., Ernst, L., Grötzinger, N., Höhn, A., Breusing, N., Reinheckel, T., & Grune, T. (2010) · Free Radical Research · doi:10.3109/10715762.2010.495127 · Cited by 59

Mouse models of neuronal ceroid lipofuscinoses: Useful pre-clinical tools to delineate disease pathophysiology and validate therapeutics

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Interactions of the proteins of neuronal ceroid lipofuscinosis: clues to function

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A novel role of the Batten disease gene CLN3: Association with BMP synthesis

Hobert, J. A., & Dawson, G. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.064 · Cited by 54

The analytical approach to the nature of lipofuscin (age pigment)

Jolly, R. D., Palmer, D. N., & Dalefield, R. R. (2002) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(01)00219-9 · Cited by 54

Mass Spectrometry-based Protein Profiling to Determine the Cause of Lysosomal Storage Diseases of Unknown Etiology

Sleat, D. E., Ding, L., Wang, S., Zhao, C., Wang, Y., Xin, W. W., Zheng, H., Moore, D. F., & Sims, K. B. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900122-mcp200 · Cited by 53

Canine neuronal ceroid lipofuscinoses: Promising models for preclinical testing of therapeutic interventions

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Neuronal ceroid lipofuscinosis in Merino sheep

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Cathepsin D exon 2 polymorphism associated with general intelligence in a healthy older population

Payton, A., Holland, F., Diggle, P. J., Rabbitt, P., Horan, M. A., Davidson, Y. S., Gibbons, L., Worthington, J., Ollier, W., & Pendleton, N. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001239 · Cited by 48

Neurodegenerative disease: the neuronal ceroid lipofuscinoses (Batten disease)

Mitchison, H. M., & Mole, S. (2001) · Current Opinion in Neurology · doi:10.1097/00019052-200112000-00019 · Cited by 48

Knock-Down of Cathepsin D Affects the Retinal Pigment Epithelium, Impairs Swim-Bladder Ontogenesis and Causes Premature Death in Zebrafish

Follo, C., Ozzano, M., Mugoni, V., Castino, R., Santoro, M. M., & Isidoro, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021908 · Cited by 49

Caenorhabditis elegans as a model for lysosomal storage disorders

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Advances in the treatment of neuronal ceroid lipofuscinosis

Rosenberg, J. B., Chen, A., Kaminsky, S. M., Crystal, R. G., & Sondhi, D. (2019) · Expert Opinion on Orphan Drugs · doi:10.1080/21678707.2019.1684258 · Cited by 41

α-Synuclein TransgenicDrosophilaAs a Model of Parkinson's Disease and Related Synucleinopathies

Mizuno, H., Fujikake, N., Wada, K., & Nagai, Y. (2010) · Parkinson s Disease · doi:10.4061/2011/212706 · Cited by 47

Neuronal ceroid-lipofuscinosis in Borderdale sheep

Jolly, R., Arthur, D. H., Kay, G. W., & Palmer, D. N. (2002) · New Zealand Veterinary Journal · doi:10.1080/00480169.2002.36311 · Cited by 42

The Intracellular Location and Function Of Proteins Of Neuronal Ceroid Lipofuscinoses

Ezaki, J., & Kominami, E. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00501.x · Cited by 42

CNS-Expressed Cathepsin D Prevents Lymphopenia in a Murine Model of Congenital Neuronal Ceroid Lipofuscinosis

Shevtsova, Z., Garrido, M., Weishaupt, J. H., Säftig, P., Bähr, M., Lühder, F., & Kügler, S. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091267 · Cited by 41

Cathepsin D Propeptide: Mechanism and Regulation of Its Interaction with the Catalytic Core

Máša, M., Marešová, L., Vondrášek, J., Horn, M., Ježek, J., & Mares, M. A. (2006) · Biochemistry · doi:10.1021/bi0614986 · Cited by 41

Over‐expression of an inactive mutant cathepsin D increases endogenous alpha‐synuclein and cathepsin B activity in SH ‐ SY 5Y cells

Crabtree, D., Dodson, M. B., Ouyang, X., Boyer‐Guittaut, M., Liang, Q., Ballestas, M. E., Fineberg, N. S., & Zhang, J. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12497 · Cited by 42

The complex interplay between autophagy and cell death pathways

Ploumi, C., Papandreou, M.-E., & Tavernarakis, N. (2022) · Biochemical Journal · doi:10.1042/bcj20210450 · Cited by 39

Cathepsin D-deficient Drosophila recapitulate the key features of neuronal ceroid lipofuscinoses

Myllykangas, L., Tyynelä, J., Page, A. W., Rubin, G. M., Haltia, M., & Feany, M. Β. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.12.019 · Cited by 79

Congenital ovine neuronal ceroid lipofuscinosis — acathepsin D deficiency with increased levels of the inactive enzyme

Tyynelä, J., Sohár, I., Sleat, D. E., Gin, R. M., Nelly, R. J. D., Baumann, M., Haltia, M., & Lobel, P. (2001) · European Journal of Paediatric Neurology · doi:10.1053/ejpn.2000.0433 · Cited by 29

Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis

Siintola, E. (2006) · Brain · doi:10.1093/brain/awl107 · Cited by 389

Another disorder finds its gene

Ramirez‐Montealegre, D. (2006) · Brain · doi:10.1093/brain/awl132 · Cited by 16

Novel mutation and the first prenatal screening of cathepsin D deficiency (CLN10)

Fritchie, K., Siintola, E., Armao, D. M., Lehesjoki, A., Marino, T., Powell, C. M., Tennison, M. B., Booker, J., Koch, S., Partanen, S., et al. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0426-7 · Cited by 79