LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

Smith, D. B., & Johnson, K. S. (1988) · Gene · doi:10.1016/0378-1119(88)90005-4 · Cited by 5,844

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347

Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae

Tsukada, M., & Ohsumi, Y. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80398-e · Cited by 1,837

A protein conjugation system essential for autophagy

Mizushima, N., Noda, T., Yoshimori, T., Tanaka, Y., Ishii, T., George, M. D., Klionsky, D. J., Ohsumi, M., & Ohsumi, Y. (1998) · Nature · doi:10.1038/26506 · Cited by 1,758

Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

Yamamoto, A., Tagawa, Y., Yoshimori, T., Moriyama, Y., Masaki, R., & Tashiro, Y. (1998) · Cell Structure and Function · doi:10.1247/csf.23.33 · Cited by 1,312

The Reversible Modification Regulates the Membrane-Binding State of Apg8/Aut7 Essential for Autophagy and the Cytoplasm to Vacuole Targeting Pathway

Kirisako, T., Ichimura, Y., Okada, H., Kabeya, Y., Mizushima, N., Yoshimori, T., Ohsumi, M., Takao, T., Noda, T., & Ohsumi, Y. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.2.263 · Cited by 1,024

Formation Process of Autophagosome Is Traced with Apg8/Aut7p in Yeast

Kirisako, T., Baba, M., Ishihara, N., Miyazawa, K., Ohsumi, M., Yoshimori, T., Noda, T., & Ohsumi, Y. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.2.435 · Cited by 881

GABAA-receptor-associated protein links GABAA receptors and the cytoskeleton

Wang, H.-B., Bedford, F., Brandon, N., Moss, S., & Olsen, R. (1999) · Nature · doi:10.1038/16264 · Cited by 754

Autophagy and related mechanisms of lysosome-mediated protein degradation

Dunn, W. A. (1994) · Trends in Cell Biology · doi:10.1016/0962-8924(94)90069-8 · Cited by 534

A New Protein Conjugation System in Human

Mizushima, N., Sugita, H., Yoshimori, T., & Ohsumi, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.33889 · Cited by 521

The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway

Bento, C. F., Ashkenazi, A., Jiménez-Sánchez, M., & Rubinsztein, D. C. (2016) · Nature Communications · doi:10.1038/ncomms11803 · Cited by 196

Autophagy in Yeast: A Review of the Molecular Machinery.

Huang, W., & Klionsky, D. J. (2002) · Cell Structure and Function · doi:10.1247/csf.27.409 · Cited by 194

Mitophagy Selectively Degrades Individual Damaged Mitochondria After Photoirradiation

Kim, I., & Lemasters, J. J. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3768 · Cited by 198

Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells

Xi, G., Hu, X., Wu, B., Jiang, H., Young, C. Y. F., Pang, Y., & Yuan, H. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.03.026 · Cited by 192

Autophagy and p62 in Cardiac Proteinopathy

Zheng, Q., Su, H., Ranek, M. J., & Wang, X. (2011) · Circulation Research · doi:10.1161/circresaha.111.244707 · Cited by 188

Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress

Peng, H., Yang, J., Li, G., You, Q., Han, W., Li, T., Gao, D., Xie, X., Lee, B., Du, J., et al. (2017) · Cell Research · doi:10.1038/cr.2017.40 · Cited by 195

Role and regulation of autophagy in cancer

Rakesh, R., Dharshini, L. C. P., Sakthivel, K. M., & Rasmi, R. R. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166400 · Cited by 198

Tubastatin A/ACY-1215 Improves Cognition in Alzheimer's Disease Transgenic Mice

Zhang, L., Liu, C., Wu, J., Tao, J.-J., Sui, X., Yao, Z., Xu, Y., Huang, L., Zhu, H., Sheng, S., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140066 · Cited by 193

eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy

Ramírez‐Valle, F., Braunstein, S. E., Zavadil, J., Formenti, S. C., & Schneider, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200710215 · Cited by 198

LC3, an autophagosome marker, is highly expressed in gastrointestinal cancers

Yoshioka (1992) · International Journal of Oncology · doi:10.3892/ijo_00000028 · Cited by 192

Methods for Assessing Autophagy and Autophagic Cell Death

Tasdemir, E., Galluzzi, L., Maiuri, M. C., Criollo, A., Vitale, I., Hangen, E., Modjtahedi, N., & Kroemer, G. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-157-4_3 · Cited by 200

Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease

Sulzer, D., Mosharov, E. V., Tallóczy, Z., Zucca, F. A., Simon, J. D., & Zecca, L. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05385.x · Cited by 195

Autophagy is essential for mouse sense of balance

Mariño, G., Fernández, Á. F., Cabrera, S., Lundberg, Y. W., Cabanillas, R., Rodríguez, F. J., Salvador-Montoliu, N., Vega, J. A., Germanà, A., Fueyo, A., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42601 · Cited by 196

Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells

Suh, Y., Afaq, F., Khan, N., Johnson, J. J., Khusro, F. H., & Mukhtar, H. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq115 · Cited by 196

Aggregable Nanoparticles-Enabled Chemotherapy and Autophagy Inhibition Combined with Anti-PD-L1 Antibody for Improved Glioma Treatment

Ruan, S., Xie, R., Qin, L., Yu, M., Xiao, W., Hu, C., Yu, W., Qian, Z., Ouyang, L., He, Q., et al. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b03968 · Cited by 192

STING orchestrates the neuronal inflammatory stress response in multiple sclerosis

Woo, M. S., Mayer, C., Binkle-Ladisch, L., Sonner, J. K., Rosenkranz, S. C., Shaposhnykov, A., Rothammer, N., Tsvilovskyy, V., Lorenz, S., Raich, L., et al. (2024) · Cell · doi:10.1016/j.cell.2024.05.031 · Cited by 197

Autophagy-regulating protease Atg4: structure, function, regulation and inhibition

Maruyama, T., & Noda, N. N. (2018) · The Journal of Antibiotics · doi:10.1038/ja.2017.104 · Cited by 190

WASH inhibits autophagy through suppression of Beclin 1 ubiquitination

Xia, P., Wang, S., Du, Y., Zhao, Z., Shi, L., Sun, L., Huang, G., Ye, B., Li, C., Dai, Z., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.189 · Cited by 194

Structural and Biochemical Bases for the Inhibition of Autophagy and Apoptosis by Viral BCL-2 of Murine γ-Herpesvirus 68

Ku, B., Woo, J., Liang, C., Lee, K.-H., Hong, H.-S., Xiaofei, E., Kim, K.-S., Jung, J. U., & Oh, B. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.0040025 · Cited by 194

Mutant LRRK2 Elicits Calcium Imbalance and Depletion of Dendritic Mitochondria in Neurons

Cherra, S. J., Steer, E. K., Gusdon, A. M., Kiselyov, K. I., & Chu, C. T. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.10.027 · Cited by 190

Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway

Liu, H., Javaheri, A., Godar, R. J., Murphy, J., Ma, X., Rohatgi, N., Mahadevan, J., Hyrc, K. L., Säftig, P., Marshall, C. A., et al. (2017) · Autophagy · doi:10.1080/15548627.2017.1368596 · Cited by 194

Glucocorticoid induced autophagy in osteocytes

Xia, X., Kar, R., Gluhak-Heinrich, J., Yao, W., Lane, N. E., Bonewald, L. F., Biswas, S. K., Lo, W.-K., & Jiang, J. X. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.160 · Cited by 193

Starvation‐induced expression of autophagy‐related genes in Arabidopsis

Rose, T. L., Bonneau, L., Der, C., Marty‐Mazars, D., & Marty, F. (2005) · Biology of the Cell · doi:10.1042/bc20040516 · Cited by 189

Conditional Expression of Parkinson's Disease-Related Mutant -Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1

Lin, X. Z., Parisiadou, L., Sgobio, C., Liu, G., Yu, J. H., Sun, L., Shim, H., Gu, X., Luo, J., Long, C., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1731-12.2012 · Cited by 192

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent

Parkhitko, A. A., Myachina, F., Morrison, T. A., Hindi, K. M., Auricchio, N., Karbowniczek, M., Wu, J. J., Finkel, T., Kwiatkowski, D. J., Yu, J. J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104361108 · Cited by 193

A role for macroautophagy in protection against 4-hydroxytamoxifen–induced cell death and the development of antiestrogen resistance

Samaddar, J. S., Gaddy, V. T., Duplantier, J., Thandavan, S. P., Shah, M. A., Smith, M. J., Browning, D. D., Rawson, J., Smith, S. B., Barrett, J. T., et al. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0447 · Cited by 190

Association Between Autophagy and Neurodegenerative Diseases

Fujikake, N., Shin, M., & Shimizu, S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00255 · Cited by 197

Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly

Seguin, S. J., Morelli, F. F., Vinet, J., Amore, D., Biasi, S. D., Poletti, A., Rubinsztein, D. C., & Carra, S. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.103 · Cited by 196

A Role for Toll-like Receptor 3 Variants in Host Susceptibility to Enteroviral Myocarditis and Dilated Cardiomyopathy

Gorbea, C. M., Makar, K. A., Pauschinger, M., Pratt, G. W., Bersola, J., Varela, J. J., David, R. M., Banks, L. D., Huang, C., Li, H., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.047464 · Cited by 192

Curcumin promotes differentiation of glioma‐initiating cells by inducing autophagy

Zhuang, W., Long, L., Zheng, B., Ji, W., Yang, N., Zhang, Q., & Liang, Z. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.02198.x · Cited by 188

Evaluation of the Protective Potential of Brain Microvascular Endothelial Cell Autophagy on Blood–Brain Barrier Integrity During Experimental Cerebral Ischemia–Reperfusion Injury

Li, H., Gao, A., Feng, D., Wang, Y., Zhang, L., Cui, Y., Лі, Б., Wang, Z., & Chen, G. (2014) · Translational Stroke Research · doi:10.1007/s12975-014-0354-x · Cited by 187

Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo

Russo, R., Berliocchi, L., Adornetto, A., Varano, G. P., Cavaliere, F., Nucci, C., Rotiroti, D., Morrone, L. A., Bagetta, G., & Corasaniti, M. T. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.29 · Cited by 186

MAP‐LC3, a promising autophagosomal marker, is processed during the differentiation and recovery of podocytes from PAN nephrosis

Asanuma, K., Tanida, I., Shirato, I., Ueno, T., Takahara, H., Nishitani, T., Kominami, E., & Tomino, Y. (2003) · The FASEB Journal · doi:10.1096/fj.02-0580fje · Cited by 186

A comprehensive glossary of autophagy-related molecules and processes

Klionsky, D. J., Codogno, P., Cuervo, A. M., Deretic, V. P., Elazar, Z., Fueyo-Margareto, J., Gewirtz, D. A., Kroemer, G., Levine, B., Mizushima, N., et al. (2010) · Autophagy · doi:10.4161/auto.6.4.12244 · Cited by 185

Copper Oxide Nanoparticles Induce Autophagic Cell Death in A549 Cells

Sun, T., Yan, Y., Zhao, Y., Guo, F., & Jiang, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043442 · Cited by 189

The Pan-Bcl-2 Inhibitor (−)-Gossypol Triggers Autophagic Cell Death in Malignant Glioma

Voss, V., Senft, C., Lang, V., Ronellenfitsch, M. W., Steinbach, J. P., Seifert, V., & Kögel, D. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0562 · Cited by 189

Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits

Jung, S., Choe, S., Woo, H., Jeong, H., An, H.-K., Moon, H., Ryu, H. Y., Yeo, B. K., Lee, Y. W., Choi, H., et al. (2020) · Autophagy · doi:10.1080/15548627.2019.1630222 · Cited by 183

A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt–TSC2-mTOR signaling

Liu, H., Zhang, Y., Yang, N., Yx, Z., Liu, X. J., Cg, L., Zhao, Y., Wang, Y.-G., Zhang, G.-G., Yang, P., et al. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.27 · Cited by 188

Negative Regulation of Vps34 by Cdk Mediated Phosphorylation

Furuya, T., Kim, M., Lipinski, M. M., Li, J., Kim, D., Lu, T., Shen, Y., Rameh, L. E., Yankner, B. A., Tsai, L., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.009 · Cited by 191

Inflammasome-Independent Modulation of Cytokine Response by Autophagy in Human Cells

Crișan, T. O., Plantinga, T. S., van de Veerdonk, F. L., Farcas, M. F., Stoffels, M., Kullberg, B. J., van der Meer, J. W. M., Joosten, L. A. B., & Netea, M. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018666 · Cited by 193

Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway

Fan, X., Wang, J., Hou, J., Lin, C.-R., Bensoussan, A., Chang, D., Liu, J., & Wang, B. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0450-z · Cited by 185

Bacterial interactions with the autophagic pathway

Dorn, B. R., Dunn, W. A., & Progulske‐Fox, A. (2002) · Cellular Microbiology · doi:10.1046/j.1462-5822.2002.00164.x · Cited by 184

The interplay between autophagy and ROS in tumorigenesis

Kongara, S., & Karantza, V. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00171 · Cited by 186

Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation

Liu, B., Fang, M., Hu, Y., Huang, B., Li, N., Chang, C., Huang, R., Xu, X., Yang, Z., Chen, Z., et al. (2013) · Autophagy · doi:10.4161/auto.27286 · Cited by 189

Laforin, the most common protein mutated in Lafora disease, regulates autophagy

Aguado, C., Sarkar, S., Korolchuk, V. I., Criado‐García, O., Vernia, S., Boya, P., Sanz, P., de Córdoba, S. R., Knecht, E., & Rubinsztein, D. C. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq190 · Cited by 188

Disruption of Autophagy at the Maturation Step by the Carcinogen Lindane Is Associated with the Sustained Mitogen-Activated Protein Kinase/Extracellular Signal–Regulated Kinase Activity

Corcelle–Termeau, E., Nebout, M., Bekri, S., Gauthier, N. C., Hofman, P. M., Poujeol, P., Fénichel, P., & Mograbi, B. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3557 · Cited by 185

Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection

Yanai, H., Matsuda, A., An, J., Koshiba, R., Nishio, J., Negishi, H., Ikushima, H., Onoe, T., Ohdan, H., Yoshida, N., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320808110 · Cited by 184

Lithium induces clearance of protease resistant prion protein in prion‐infected cells by induction of autophagy

Heiseke, A., Aguib, Y., Riemer, C., Baier, M., & Schätzl, H. M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05906.x · Cited by 189

Autophagy in Yeast: Mechanistic Insights and Physiological Function

Abeliovich, H., & Klionsky, D. J. (2001) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.65.3.463-479.2001 · Cited by 183

Deletion of the Huntingtin Polyglutamine Stretch Enhances Neuronal Autophagy and Longevity in Mice

Zheng, S., Clabough, E. B. D., Sarkar, S., Futter, M., Rubinsztein, D. C., & Zeitlin, S. O. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000838 · Cited by 192

The role of autophagy in follicular development and atresia in rat granulosa cells

Choi, J. Y., Jo, M., Lee, E. Y., Yoon, B.-K., & Choi, D. S. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.11.021 · Cited by 183

Melatonin‐enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid hemorrhage

Chen, J., Wang, L., Wu, C., Hu, Q., Gu, C., Yan, F., Li, J., Yan, W. X., & Chen, G. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12086 · Cited by 183

Mammalian macroautophagy at a glance

Ravikumar, B., Futter, M., Jahreiss, L., Korolchuk, V. I., Lichtenberg, M., Luo, S., Massey, D. C. O., Menzies, F. M., Narayanan, U., Renna, M., et al. (2009) · Journal of Cell Science · doi:10.1242/jcs.031773 · Cited by 196

The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy

Lee, E.-J., & Tournier, C. (2011) · Autophagy · doi:10.4161/auto.7.7.15450 · Cited by 186

Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells

Zou, Z., Yuan, Z., Zhang, Q., Long, Z., Chen, J., Tang, Z., Zhu, Y., Chen, S., Xu, J., Yan, M., et al. (2012) · Autophagy · doi:10.4161/auto.22110 · Cited by 184

Induction of Autophagy Causes Dramatic Changes in the Subcellular Distribution of GFP‐Rab24

Munafó, D. B., & Colombo, M. I. (2002) · Traffic · doi:10.1034/j.1600-0854.2002.30704.x · Cited by 182

Autophagy–physiology and pathophysiology

Uchiyama, Y., Shibata, M., Koike, M., Yoshimura, K., & Sasaki, M. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0406-y · Cited by 188

Current knowledge of the pre‐autophagosomal structure (PAS)

Suzuki, K., & Ohsumi, Y. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.02.001 · Cited by 184

Autophagosome proteins LC3A, LC3B and LC3C have distinct subcellular distribution kinetics and expression in cancer cell lines.

Koukourakis, M. I., Kalamida, D., Giatromanolaki, A., Zois, C. E., Sivridis, E., Pouliliou, S., Mitrakas, A., Gatter, K. C., & Harris, A. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137675 · Cited by 183

Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos

He, C., Bartholomew, C. R., Zhou, W., & Klionsky, D. J. (2009) · Autophagy · doi:10.4161/auto.5.4.7768 · Cited by 186

Autophagy Interplay with Apoptosis and Cell Cycle Regulation in the Growth Inhibiting Effect of Resveratrol in Glioma Cells

Filippi‐Chiela, E. C., Villodre, E. S., Zamin, L. L., & Lenz, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020849 · Cited by 181

A Double‐Edged Sword with Therapeutic Potential: An Updated Role of Autophagy in Ischemic Cerebral Injury

Wei, K., Wang, P., & Miao, C. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12005 · Cited by 183

Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells

Hill, B. G., Haberzettl, P., Ahmed, Y., Srivastava, S., & Bhatnagar, A. (2008) · Biochemical Journal · doi:10.1042/bj20071063 · Cited by 187

Autophagy protects neuron from Aβ-induced cytotoxicity

Hung, S., Huang, W., Liou, H., & Fu, W. (2009) · Autophagy · doi:10.4161/auto.5.4.8096 · Cited by 183

Pathological apoptosis in the developing brain

Blomgren, K., Leist, M., & Groc, L. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0754-4 · Cited by 183

Induction of Autophagy in Porcine Kidney Cells by Quantum Dots: A Common Cellular Response to Nanomaterials?

Stern, S. T., Zolnik, B. S., McLeland, C. B., Clogston, J. D., Zheng, J., & McNeil, S. E. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn137 · Cited by 184

Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death

Gao, W., Shen, Z., Shang, L., & Wang, X. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2011.33 · Cited by 178

The Epidermal Growth Factor Receptor Antibody Cetuximab Induces Autophagy in Cancer Cells by Downregulating HIF-1α and Bcl-2 and Activating the Beclin 1/hVps34 Complex

Li, X., & Fan, Z. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0157 · Cited by 179

Autophagy for Cancer Therapy through Inhibition of Pro-apoptotic Proteins and Mammalian Target of Rapamycin Signaling

Kim, K. W., Mutter, R. W., Cao, C., Albert, J. M., Freeman, M. L., Hallahan, D. E., & Lu, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607094200 · Cited by 179

Autophagy is required for necrotic cell death in Caenorhabditis elegans

Samara, C., Syntichaki, P., & Tavernarakis, N. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402231 · Cited by 181

Regulation of Autophagy By Signaling Through the Atg1/ULK1 Complex

Papinski, D., & Kraft, C. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.03.030 · Cited by 186

Accumulation of autophagosomes confers cytotoxicity

Button, R. W., Roberts, S. L., Willis, T. L., Hanemann, C. O., & Luo, S. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.782276 · Cited by 186

Intracellular Fate of Nanoparticles with Polydopamine Surface Engineering and a Novel Strategy for Exocytosis-Inhibiting, Lysosome Impairment-Based Cancer Therapy

Ding, L., Zhu, X., Wang, Y., Shi, B., Ling, X., Chen, H., Nan, W., Barrett, A., Guo, Z., Tao, W., et al. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b03021 · Cited by 180

Emerging role of mitophagy in cardiovascular physiology and pathology

Morales, P. E., Arias-Durán, C., Ávalos-Guajardo, Y., Aedo, G., Verdejo, H., Parra, V., & Lavandero, S. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.09.006 · Cited by 179

The late stages of autophagy: how does the end begin?

Noda, T., Fujita, N., & Yoshimori, T. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.54 · Cited by 190

Metabolic Profiling of Hypoxic Cells Revealed a Catabolic Signature Required for Cell Survival

Frezza, C., Zheng, L., Tennant, D. A., Papkovsky, D. B., Hedley, B. A., Kalna, G., Watson, D. G., & Gottlieb, E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024411 · Cited by 177

Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation

Knævelsrud, H., Søreng, K., Raiborg, C., Håberg, K., Rasmuson, F., Brech, A., Liestøl, K., Rusten, T. E., Stenmark, H., Neufeld, T. P., et al. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201205129 · Cited by 177

DAP1, a Novel Substrate of mTOR, Negatively Regulates Autophagy

Koren, I., Reem, E., & Kimchi, A. (2010) · Current Biology · doi:10.1016/j.cub.2010.04.041 · Cited by 188

Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans

Gassen, N. C., Hartmann, J., Zschocke, J., Stepan, J., Hafner, K., Zellner, A., Kirmeier, T., Kollmannsberger, L. K., Wagner, K. V., Dedic, N., et al. (2014) · PLoS Medicine · doi:10.1371/journal.pmed.1001755 · Cited by 180

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