LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

Smith, D. B., & Johnson, K. S. (1988) · Gene · doi:10.1016/0378-1119(88)90005-4 · Cited by 5,844

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347

Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae

Tsukada, M., & Ohsumi, Y. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80398-e · Cited by 1,837

A protein conjugation system essential for autophagy

Mizushima, N., Noda, T., Yoshimori, T., Tanaka, Y., Ishii, T., George, M. D., Klionsky, D. J., Ohsumi, M., & Ohsumi, Y. (1998) · Nature · doi:10.1038/26506 · Cited by 1,758

Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

Yamamoto, A., Tagawa, Y., Yoshimori, T., Moriyama, Y., Masaki, R., & Tashiro, Y. (1998) · Cell Structure and Function · doi:10.1247/csf.23.33 · Cited by 1,312

The Reversible Modification Regulates the Membrane-Binding State of Apg8/Aut7 Essential for Autophagy and the Cytoplasm to Vacuole Targeting Pathway

Kirisako, T., Ichimura, Y., Okada, H., Kabeya, Y., Mizushima, N., Yoshimori, T., Ohsumi, M., Takao, T., Noda, T., & Ohsumi, Y. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.2.263 · Cited by 1,024

Formation Process of Autophagosome Is Traced with Apg8/Aut7p in Yeast

Kirisako, T., Baba, M., Ishihara, N., Miyazawa, K., Ohsumi, M., Yoshimori, T., Noda, T., & Ohsumi, Y. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.2.435 · Cited by 881

GABAA-receptor-associated protein links GABAA receptors and the cytoskeleton

Wang, H.-B., Bedford, F., Brandon, N., Moss, S., & Olsen, R. (1999) · Nature · doi:10.1038/16264 · Cited by 754

Autophagy and related mechanisms of lysosome-mediated protein degradation

Dunn, W. A. (1994) · Trends in Cell Biology · doi:10.1016/0962-8924(94)90069-8 · Cited by 534

A New Protein Conjugation System in Human

Mizushima, N., Sugita, H., Yoshimori, T., & Ohsumi, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.33889 · Cited by 521

Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways

Tang, G., Yue, Z., Tallóczy, Z., Hagemann, T. L., Cho, W., Messing, A., Sulzer, D., & Goldman, J. E. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn042 · Cited by 176

Inhibition of Autophagy in Mitotic Animal Cells

Eskelinen, E., Prescott, A. R., Cooper, J., Brachmann, S. M., Wang, L., Tang, X., Backer, J., & Lucocq, J. M. (2002) · Traffic · doi:10.1034/j.1600-0854.2002.31204.x · Cited by 176

Apoptosis, senescence, and autophagy in rat nucleus pulposus cells: Implications for diabetic intervertebral disc degeneration

Jiang, L., Zhang, X., Zheng, X., Ru, A., Ni, X., Wu, Y., Tian, N., Huang, Y., Xue, E., Wang, X., et al. (2012) · Journal of Orthopaedic Research® · doi:10.1002/jor.22289 · Cited by 171

Germ cell-specific Atg7 knockout results in primary ovarian insufficiency in female mice

Song, Z.-H., Yu, H., Wang, P., Mao, G.-K., Liu, W.-X., Li, M.-N., Wang, H.-N., Shang, Y.-L., Liu, C., Xu, Z., et al. (2015) · Cell Death and Disease · doi:10.1038/cddis.2014.559 · Cited by 174

Enterovirus 71‐induced autophagy detected in vitro and in vivo promotes viral replication

Huang, S., Chang, C., Wang, P., Tsai, Y. L., & Liu, H. (2009) · Journal of Medical Virology · doi:10.1002/jmv.21502 · Cited by 171

A Screen of Coxiella burnetii Mutants Reveals Important Roles for Dot/Icm Effectors and Host Autophagy in Vacuole Biogenesis

Newton, H. J., Kohler, L. J., McDonough, J. A., Temoche-Diaz, M. M., Crabill, E., Hartland, E. L., & Roy, C. R. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004286 · Cited by 171

TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic

Lamb, C. A., Nühlen, S., Judith, D., Frith, D., Snijders, A. P., Behrends, C., & Tooze, S. A. (2015) · The EMBO Journal · doi:10.15252/embj.201592695 · Cited by 176

Autophagy and Stem Cells: Self-Eating for Self-Renewal

Chang, N. C. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00138 · Cited by 183

Aneuploidy-induced cellular stresses limit autophagic degradationPreprint

Santaguida, S., Vasile, E., White, E., & Amon, A. (2015) · Genes & Development · doi:10.1101/gad.269118.115 · Cited by 173

Autophagy-Related Proteins, LC3 and Beclin-1, in Placentas From Pregnancies Complicated by Preeclampsia

Oh, S., Choi, S., Kim, K., Cho, E. Y., Kim, J.-H., & Roh, C. (2008) · Reproductive Sciences · doi:10.1177/1933719108319159 · Cited by 167

Autophagic and apoptotic response to stress signals in mammalian cells

Ferraro, E., & Cecconi, F. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.02.006 · Cited by 171

Plant natural compounds: targeting pathways of autophagy as anti‐cancer therapeutic agents

Zhang, X., Chen, L., Ouyang, L., Cheng, Y., & Liu, B. (2012) · Cell Proliferation · doi:10.1111/j.1365-2184.2012.00833.x · Cited by 175

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

Esselens, C. W., Oorschot, V. M. J., Baert, V., Raemaekers, T., Spittaels, K., Serneels, L., Zheng, H., Säftig, P., Strooper, B. D., Klumperman, J., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200406060 · Cited by 170

Autophagy Is Rapidly Induced by Salt Stress and Is Required for Salt Tolerance in Arabidopsis

Luo, L., Zhang, P., Zhu, R., Fu, J., Su, J., Zheng, J., Wang, Z., Wang, D., & Gong, Q. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01459 · Cited by 173

Down-Regulation of Lncrna MALAT1 Attenuates Neuronal Cell Death Through Suppressing Beclin1-Dependent Autophagy by Regulating Mir-30a in Cerebral Ischemic Stroke

Guo, D., Ma, J., Lei, Y., Li, T., Li, Z., Han, X., & Shui, S. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000480337 · Cited by 169

The Function of Autophagy in Neurodegenerative Diseases

Kiriyama, Y., & Nochi, H. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161125990 · Cited by 178

Autophagy induction by trehalose: Molecular mechanisms and therapeutic impacts

Moghaddam, K. H., Caraglia, M., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26583 · Cited by 173

STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury

Abdullah, A. D. I., Zhang, M., Frugier, T., Bedoui, S., Taylor, J. M., & Crack, P. J. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1354-7 · Cited by 171

Autophagy and apoptosis cascade: which is more prominent in neuronal death?

Gupta, R. V., Ambasta, R. K., & Kumar, P. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04004-4 · Cited by 174

Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy

Chen, D., Gao, F., Li, B., Wang, H., Xu, Y., Zhu, C., & Wang, G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.101469 · Cited by 170

Genistein-induced apoptosis and autophagocytosis in ovarian cancer cells

Gossner, G., CHOI, M., Tan, L., Fogoros, S. K., Griffith, K. C., KUENKER, M., & LIU, J. (2007) · Gynecologic Oncology · doi:10.1016/j.ygyno.2006.11.009 · Cited by 170

Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer

Kim, K. W., Hwang, M., Moretti, L., Jaboin, J. J., Cha, Y. I., & Lu, J. (2008) · Autophagy · doi:10.4161/auto.6058 · Cited by 168

Amino Acids as Regulators of Proteolysis

Kadowaki, M., & Kanazawa, T. (2003) · Journal of Nutrition · doi:10.1093/jn/133.6.2052s · Cited by 168

Co-localization of constituents of the dengue virus translation and replication machinery with amphisomes

Panyasrivanit, M., Khakpoor, A., Wikan, N., & Smith, D. R. (2009) · Journal of General Virology · doi:10.1099/vir.0.005355-0 · Cited by 178

Concanavalin A induces autophagy in hepatoma cells and has a therapeutic effect in a murine in situ hepatoma model

Chang, C., Yang, M.-C., Liu, H., Lin, Y.-S., & Lei, H.-Y. (2007) · Hepatology · doi:10.1002/hep.21509 · Cited by 168

The crystal structure of microtubule‐associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8

Sugawara, K., Suzuki, N. N., Fujioka, Y., Mizushima, N., Ohsumi, Y., & Inagaki, F. (2004) · Genes to Cells · doi:10.1111/j.1356-9597.2004.00750.x · Cited by 158

Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases

Webb, J. L., Ravikumar, B., & Rubinsztein, D. C. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.02.003 · Cited by 188

Induction of autophagy promotes differentiation of glioma‐initiating cells and their radiosensitivity

Zhuang, W., Li, B.-Z., Long, L., Chen, L., Huang, Q., & Liang, Z. (2011) · International Journal of Cancer · doi:10.1002/ijc.25975 · Cited by 170

Modification of Cellular Autophagy Protein LC3 by Poliovirus

Taylor, M. P., & Kirkegaard, K. (2007) · Journal of Virology · doi:10.1128/jvi.00755-07 · Cited by 172

Autophagy in tumor suppression and cancer therapy

Kung, C.-P., Budina, A., Balaburski, G. M., Bergenstock, M., & Murphy, M. E. (2011) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v21.i1.50 · Cited by 168

Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death

Oral, Ö., Arslan, D. Ö., Itah, Z., Naghavi, A., Deveci, R., Karaçalı, S., & Gözüaçık, D. (2012) · APOPTOSIS · doi:10.1007/s10495-012-0735-0 · Cited by 174

Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming

Ma, T., Li, J., Xu, Y., Chen, Y., Xu, T., Wang, H., Liu, K., Cao, N., Nie, B., Zhu, S., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3256 · Cited by 168

Autophagy in colorectal cancer: An important switch from physiology to pathology

Burada, F. (2015) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v7.i11.271 · Cited by 171

Pro-survival autophagy and cancer cell resistance to therapy

Das, C. K., Mandal, M., & Kögel, D. (2018) · Cancer and Metastasis Reviews · doi:10.1007/s10555-018-9727-z · Cited by 172

p62/ SQSTM1 and Selective Autophagy in Cardiometabolic Diseases

Jeong, S., Zhang, X., Rodríguez-Vélez, A., Evans, T. D., & Razani, B. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7649 · Cited by 169

Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance

Li, S., Song, Y., Quach, C., Guo, H., Jang, G.-B., Maazi, H., Zhao, S., Sands, N. A., Liu, Q., In, G. K., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09634-8 · Cited by 173

Lipin-1 regulates autophagy clearance and intersects with statin drug effects in skeletal muscle

Zhang, P., Verity, M. A., & Reue, K. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.003 · Cited by 166

The actin cytoskeleton participates in the early events of autophagosome formation upon starvation induced autophagy

Aguilera, M. O., Berón, W., & Colombo, M. I. (2012) · Autophagy · doi:10.4161/auto.21459 · Cited by 175

Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors

Wu, Z., Chang, P., Yang, J. C., Chu, C.-Y., Wang, L., Chen, N., Ma, A.-H., Desai, S. J., Lo, S. H., Evans, C. P., et al. (2010) · Genes & Cancer · doi:10.1177/1947601909358324 · Cited by 167

Endosomal Rab cycles regulate Parkin-mediated mitophagy

Yamano, K., Wang, C., Sarraf, S. A., Münch, C., Kikuchi, R., Noda, N. N., Hizukuri, Y., Kanemaki, M. T., Harper, J. W., Tanaka, K., et al. (2018) · eLife · doi:10.7554/elife.31326 · Cited by 174

Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins

Wirth, M., Zhang, W., Razi, M., Nyoni, L., Joshi, D., O’Reilly, N., Johansen, T., Tooze, S. A., & Mouilleron, S. (2019) · Nature Communications · doi:10.1038/s41467-019-10059-6 · Cited by 166

Regulation of Autophagy by Neuropathological Protein TDP-43

Bose, J. K., Huang, C.-C., & Shen, C.-K. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.237115 · Cited by 165

Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesis

Barth, J. M. I., Szabad, J., Hafen, E., & Köhler, K. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.157 · Cited by 165

Human WIPI‐1 puncta‐formation: A novel assay to assess mammalian autophagy

Proikas-Cezanne, T., Ruckerbauer, S., Stierhof, Y.-D., Berg, C., & Nordheim, A. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.06.040 · Cited by 165

HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones

Vos, M. J., Zijlstra, M. P., Kanon, B., van Waarde-Verhagen, M. A. W. H., Brunt, E. R. P., Oosterveld-Hut, H. M. J., Carra, S., Sibon, O. C. M., & Kampinga, H. H. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq398 · Cited by 166

The N-Degron Pathway Mediates ER-phagy

Ji, C. H., Kim, H. Y., Heo, A. J., Lee, S. H., Lee, M. J., Kim, S., Srinivasrao, G., Mun, S. R., Cha‐Molstad, H., Ciechanover, A. J., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.06.028 · Cited by 166

Insulin secretory granules control autophagy in pancreatic β cells

Goginashvili, A., Zhang, Z., Erbs, E., Spiegelhalter, C., Kessler, P., Mihlan, M., Pasquier, A., Krupina, K., Schieber, N., Cinque, L., et al. (2015) · Science · doi:10.1126/science.aaa2628 · Cited by 160

Tau – an inhibitor of deacetylase HDAC6 function

Perez, M., Santa‐Maria, I., De Barreda, E. G., Zhu, X., Cuadros, R., Cabrero, J. R., Sanchez‐Madrid, F., Dawson, H. N., Vitek, M. P., Perry, G., et al. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06102.x · Cited by 182

CCL2 Protects Prostate Cancer PC3 Cells from Autophagic Death via Phosphatidylinositol 3-Kinase/AKT-dependent Survivin Up-regulation

Roca, H., Varsos, Z. S., & Pienta, K. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801073200 · Cited by 168

Suppression of autophagy permits successful enzyme replacement therapy in a lysosomal storage disorder—murine Pompe disease

Raben, N., Schreiner, C. N., Baum, R., Takikita, S., Xu, S., Xie, T., Myerowitz, R., Komatsu, M., van der Meulen, J. H., Nagaraju, K., et al. (2010) · Autophagy · doi:10.4161/auto.6.8.13378 · Cited by 168

Bafilomycin A1 Inhibits Chloroquine-Induced Death of Cerebellar Granule Neurons

Shacka, J. J., Klocke, B. J., Shibata, M., Uchiyama, Y., Datta, G., Schmidt, R. E., & Roth, K. A. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.018408 · Cited by 164

Cell Death in the Developing Brain after Hypoxia-Ischemia

Thornton, C., Leaw, B., Mallard, C. E., Nair, S., Jinnai, M., & Hagberg, H. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00248 · Cited by 166

Autophagic Cell Death of Pancreatic Acinar Cells in Serine Protease Inhibitor Kazal Type 3—Deficient Mice

Ohmuraya, M., Hirota, M., Araki, M., Mizushima, N., Matsui, M., Mizumoto, T., Haruna, K., Kume, S., Takeya, M., Ogawa, M., et al. (2005) · Gastroenterology · doi:10.1016/j.gastro.2005.05.057 · Cited by 167

ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells

Chen, J.-H., Zhang, P., Chen, W.-D., Li, D., Wu, X.-Q., Deng, R., Jiao, L., Li, X., Ji, J., Feng, G., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1009767 · Cited by 168

Rubicon and PLEKHM1 Negatively Regulate the Endocytic/Autophagic Pathway via a Novel Rab7-binding Domain

Tabata, K., Matsunaga, K., Sakane, A., Sasaki, T., Noda, T., & Yoshimori, T. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-06-0495 · Cited by 167

Utilizing flow cytometry to monitor autophagy in living mammalian cells

Shvets, E., Fass, E., & Elazar, Z. (2008) · Autophagy · doi:10.4161/auto.5939 · Cited by 163

Small molecule enhancers of autophagy for neurodegenerative diseases

Sarkar, S., & Rubinsztein, D. C. (2008) · Molecular BioSystems · doi:10.1039/b804606a · Cited by 166

Atg1‐mediated myosin II activation regulates autophagosome formation during starvation‐induced autophagy

Tang, H.-W., Wang, Y., Wang, S.-L., Wu, M.-H., Lin, S., & Chen, G. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.338 · Cited by 165

Regulation and function of autophagy in pancreatic cancer

Li, J., Chen, X., Kang, R., Zeh, H. J., Klionsky, D. J., & Tang, D. (2020) · Autophagy · doi:10.1080/15548627.2020.1847462 · Cited by 167

Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress

Ullman, E., Fan, Y., Stawowczyk, M., Chen, H.-M., Yue, Z., & Zong, W.-X. (2008) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402234 · Cited by 161

Exploiting Cannabinoid-Induced Cytotoxic Autophagy to Drive Melanoma Cell Death

Armstrong, J. L., Hill, D. S., McKee, C. S., Hernández‐Tiedra, S., Lorente, M., López-Valero, I., Anagnostou, M., Babatunde, F., Corazzari, M., Redfern, C. P. F., et al. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.45 · Cited by 161

Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy

Higdon, A. N., Benavides, G. A., Chacko, B. K., Ouyang, X., Johnson, M. S., Landar, A. L., Zhang, J., & Darley-Usmar, V. M. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00584.2011 · Cited by 161

Functional drug screening reveals anticonvulsants as enhancers of mTOR‐independent autophagic killing of Mycobacterium tuberculosis through inositol depletion

Schiebler, M., Brown, K., Hegyi, K., Newton, S. M., Renna, M., Hepburn, L., Klapholz, C., Coulter, S., Obregón‐Henao, A., Henao-Tamayo, M. I., et al. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201404137 · Cited by 162

Atg9A trafficking through the recycling endosomes is required for autophagosome formation

Imai, K., Hao, F., Fujita, N., Tsuji, Y., Oe, Y., Araki, Y., Hamasaki, M., Noda, T., & Yoshimori, T. (2016) · Journal of Cell Science · doi:10.1242/jcs.196196 · Cited by 175

Autophagy limits activation of the inflammasomes

Takahama, M., Akira, S., & Saitoh, T. (2017) · Immunological Reviews · doi:10.1111/imr.12613 · Cited by 163

Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1

Li, Y., Zhou, D., Ren, Y., Zhang, Z., Guo, X., Ma, M., Xue, Z., Lv, J., Liu, H., Xi, Q., et al. (2019) · Autophagy · doi:10.1080/15548627.2018.1522467 · Cited by 152

Autophagy: a potential key contributor to the therapeutic action of mesenchymal stem cells

Ceccariglia, S., Cargnoni, A., Silini, A. R., & Parolini, O. (2019) · Autophagy · doi:10.1080/15548627.2019.1630223 · Cited by 165

Emerging degrader technologies engaging lysosomal pathways

Ding, Y., Xing, D., Fei, Y., & Lu, B. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00624c · Cited by 165

Autophagy Dysregulation in Amyotrophic Lateral Sclerosis

Chen, S., Zhang, X., Song, L., & Le, W. (2011) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00546.x · Cited by 170

The Role of AKT/mTOR Pathway in Stress Response to UV-Irradiation: Implication in Skin Carcinogenesis by Regulation of Apoptosis, Autophagy and Senescence

Strozyk, E. A., & Kulms, D. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140815260 · Cited by 162

Markers of Autophagy Are Downregulated in Failing Human Heart After Mechanical Unloading

Kassiotis, C., Ballal, K., Wellnitz, K., Vela, D. C., Gong, M., Salazar, R., Frazier, O. H., & Taegtmeyer, H. (2009) · Circulation · doi:10.1161/circulationaha.108.842252 · Cited by 166

Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana

Williams, R. A., Tetley, L., Mottram, J. C., & Coombs, G. H. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05274.x · Cited by 140

Chapter 2 Methods for Monitoring Autophagy Using GFP‐LC3 Transgenic Mice

Mizushima, N. (2009) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)03602-1 · Cited by 161

Dihydrolipoic Acid–Gold Nanoclusters Regulate Microglial Polarization and Have the Potential To Alter Neurogenesis

Xiao, L., Wei, F., Zhou, Y., Anderson, G. J., Frazer, D. M., Lim, Y. C., Liu, T., & Xiao, Y. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b04216 · Cited by 160

Constitutive autophagy: vital role in clearance of unfavorable proteins in neurons

Komatsu, M., Ueno, T., Waguri, S., Uchiyama, Y., Kominami, E., & Tanaka, K. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402120 · Cited by 170

Ginsenoside F2 induces apoptosis accompanied by protective autophagy in breast cancer stem cells

Mai, T. T., Moon, J., Song, Y., Viet, P. Q., Phuc, P. V., Lee, J. M., Yi, T., Cho, M., & Cho, S. K. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.01.045 · Cited by 161

Regulatory Coordination between Two Major Intracellular Homeostatic Systems

Dokładny, K., Zuhl, M., Mandell, M. A., Bhattacharya, D., Schneider, S. M., Deretic, V. P., & Moseley, P. L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.462408 · Cited by 164

Coxsackievirus Infection Induces Autophagy-Like Vesicles and Megaphagosomes in Pancreatic Acinar Cells In Vivo

Kemball, C. C., Alirezaei, M., Flynn, C. T., Wood, M. R., Harkins, S., Kiosses, W. B., & Whitton, J. L. (2010) · Journal of Virology · doi:10.1128/jvi.01417-10 · Cited by 161

Dengue Virus and Autophagy

Heaton, N. S., & Randall, G. C. (2011) · Viruses · doi:10.3390/v3081332 · Cited by 160

Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance

Aichinger, M., Wu, C., Nedjic, J., & Klein, L. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20122149 · Cited by 166

Induction of macroautophagy in human colon cancer cells by soybean B-group triterpenoid saponins

Ellington, A. A. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh297 · Cited by 159

Autophagy-mediated clearance of aggresomes is not a universal phenomenon

Wong, E. S. P., Tan, J. M. M., Soong, W.-E., Hussein, K., Nukina, N., Dawson, V. L., Dawson, T. M., Cuervo, A. M., & Lim, K. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn157 · Cited by 162

Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

Wang, C., Niederstrasser, H., Douglas, P. M., Lin, R., Jaramillo, J., Li, Y., Oswald, N. W., Zhou, A., McMillan, E. A., Mendiratta, S., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02332-3 · Cited by 158

Microglia change from a reactive to an age-like phenotype with the time in culture

Caldeira, C., Oliveira, A. F., Cunha, C., Vaz, A. R., Falcão, A. S., Fernandes, A., & Brites, D. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00152 · Cited by 156

MBSJ MCC Young Scientist Award 2009 REVIEW: Selective autophagy regulates various cellular functions

Komatsu, M., & Ichimura, Y. (2010) · Genes to Cells · doi:10.1111/j.1365-2443.2010.01433.x · Cited by 163

Measurement of Autophagy in Cells and Tissues

Tanida, I., & Waguri, S. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-756-3_13 · Cited by 162

MIR181Aregulates starvation- and rapamycin-induced autophagy through targeting ofATG5

Tekirdağ, K. A., Korkmaz, G., Öztürk, D. G., Agami, R., & Gözüaçık, D. (2013) · Autophagy · doi:10.4161/auto.23117 · Cited by 161

Inhibition of Autophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1 Infection

Sun, Y., Li, C., Shu, Y., Ju, X., Zou, Z., Wang, H., Rao, S., Guo, F., Liu, H., Nan, W., et al. (2012) · Science Signaling · doi:10.1126/scisignal.2001931 · Cited by 158

Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study

Shen, S., Kepp, O., Michaud, M., Martins, I., Minoux, H., Métivier, D., Maiuri, M. C., Kroemer, R. T., & Kroemer, G. (2011) · Oncogene · doi:10.1038/onc.2011.168 · Cited by 163

Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry

Schläfli, A. M., Berezowska, S., Adams, O. J., Langer, R., & Tschan, M. P. (2015) · European Journal of Histochemistry · doi:10.4081/ejh.2015.2481 · Cited by 161

Prognostic relevance of autophagy-related markers LC3, p62/sequestosome 1, Beclin-1 and ULK1 in colorectal cancer patients with respect to KRAS mutational status

Schmitz, K. J., Ademi, C., Bertram, S., Schmid, K. W., & Baba, H. A. (2016) · World Journal of Surgical Oncology · doi:10.1186/s12957-016-0946-x · Cited by 161

Autophagy and Longevity.

Nakamura, S., & Yoshimori, T. (2018) · PubMed Central · doi:10.14348/molcells.2018.2333 · Cited by 163

A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications

Guo, S., Liang, Y., Murphy, S. F., Huang, A., Shen, H., Kelly, D. F., Sobrado, P., & Sheng, Z. (2015) · Autophagy · doi:10.1080/15548627.2015.1017181 · Cited by 148

The Interplay between Pro-Death and Pro-Survival Signaling Pathways in Myocardial Ischemia/Reperfusion Injury: Apoptosis Meets Autophagy

Hamacher‐Brady, A., Brady, N. R., & Gottlieb, R. A. (2006) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-006-0583-7 · Cited by 159

Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress

Gurkar, A. U., Chu, K., Raj, L., Bouley, R., Lee, S., Kim, Y., Dunn, S. E., Mandinova, A., & Lee, S. W. (2013) · Nature Communications · doi:10.1038/ncomms3189 · Cited by 160

Ultrastructural and biochemical analyses of hepatitis C virus-associated host cell membranes

Ferraris, P., Blanchard, E., & Roingeard, P. (2010) · Journal of General Virology · doi:10.1099/vir.0.022186-0 · Cited by 157

Sirt3 confers protection against neuronal ischemia by inducing autophagy: Involvement of the AMPK-mTOR pathway

Dai, S., Chen, T., Li, X., Yue, K., Luo, P., Yang, L., Zhu, J., Wang, Y., Fei, Z., & Jiang, X. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.005 · Cited by 158

Mitophagy receptor FUNDC1 is regulated by PGC-1α/NRF1 to fine tune mitochondrial homeostasis

Liu, L., Li, Y., Wang, J., Zhang, D., Wu, H., Li, W., Wei, H., Ta, N., Fan, Y., Liu, Y., et al. (2021) · EMBO Reports · doi:10.15252/embr.202050629 · Cited by 159

ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macrophages

Biswas, D., Qureshi, O. S., Lee, W.-Y. J., Croudace, J. E., Mura, M., & Lammas, D. A. (2008) · BMC Immunology · doi:10.1186/1471-2172-9-35 · Cited by 161

Autophagosomes induced by a bacterial Beclin 1 binding protein facilitate obligatory intracellular infection

Niu, H., Xiong, Q., Yamamoto, A., Hayashi, M., & Rikihisa, Y. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218674109 · Cited by 161

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

Kabeya, Y., Mizushima, N., Yamamoto, A., Oshitani-Okamoto, S., Ohsumi, Y., & Yoshimori, T. (2004) · Journal of Cell Science · doi:10.1242/jcs.01131 · Cited by 1,394

Molecular cloning and characterization of rat LC3A and LC3B—Two novel markers of autophagosome

Wu, J., Dang, Y., Su, W., Liu, C., Ma, H., Shan, Y., Pei, Y., Wan, B., Guo, J., & Yu, L. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.211 · Cited by 180

LC3 and Autophagy

Tanida, I., Ueno, T., & Kominami, E. (2008) · Methods in Molecular Biology™ · doi:10.1007/978-1-59745-157-4_4 · Cited by 1,785

Molecular Dynamics Simulations of Microtubule-associated protein 1A/1B-light chain 3 (LC3) and its membrane associated form(LC3-II)

Mathew, S. (2017) · doi:10.7916/d8z60w0j

Autophagy protein LC3C binding to phospholipid and interaction with lipid membranes

Ballesteros, U., Etxaniz, A., Iriondo, M. N., Varela, Y. R., Lázaro, M., Viguera, A. R., Montes, L. R., Valle, M., Goñi, F. M., & Alonso, A. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.05.129 · Cited by 10